The methodical manual presents the results of theoretical and empirical study of the problem of self-determination in relation to the future profession of gifted lyceum students. The specifics of professional orientation and career counseling of gifted lyceum students in modern conditions are described. The results of the experimental study of self-determination of the future profession of students with different types of talents are highlighted. The vocational guidance-diagnostic test system "Interests and Abilities" is presented, which is aimed at the bilateral study of personality: motivational structure (professional interests, aptitudes) and the structure of inclinations and abilities. The manual is addressed to teachers, psychologists, employees of educational institutions working with gifted children and students, as well as researchers, graduate students, teachers of psychological and pedagogical disciplines