Assessment of Response to Therapy

Gholamrezanezhad, Ali; Chirindel, Alin; Subramaniam, Rathan

doi:10.1007/174_2012_707

Cited by 3 publications

(2 citation statements)

References 254 publications

(344 reference statements)

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“…At present, the two are considered comparable for most clinical applications, though evidence is building that PET/MRI may be superior for certain applications, such as the confident diagnosis of osteomyelitis (40). PET/CT remains the more commonly performed examination because of its greater availability and lower cost (41).…”

Section: Pet/ct Versus Pet/mrimentioning

confidence: 99%

Nononcologic Applications of PET/CT and PET/MRI in Musculoskeletal, Orthopedic, and Rheumatologic Imaging: General Considerations, Techniques, and Radiopharmaceuticals

Gholamrezanezhad

Basques

Batouli

et al. 2017

J. Nucl. Med. Technol.

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Positron Emission Tomography (PET) is often underutilized in the field of musculoskeletal imaging, with key reasons including the excellent performance of conventional musculoskeletal MRI, the limited spatial resolution of PET, and the lack of reimbursement for PET for non-oncologic musculoskeletal indications. However, with improvements in PET/CT and PET/MR imaging over the last decade as well as an increased understanding of the pathophysiology of musculoskeletal diseases, there is an emerging potential for PET as a primary or complementary modality in the management of rheumatologic and orthopedic patients. Specific advantages of PET include the convenience of whole body imaging in a single session, the relative resilience of the modality in the imaging of metallic implants compared to CT and MRI, the ability to evaluate deep joints not amenable to palpation, and the potential for improved specificity of diagnosis with novel radiopharmaceuticals. In this review, we discuss multiple radiopharmaceuticals and technical consideration of PET/CT and PET/MRI that can be employed in imaging of non-tumoral bone and soft tissue disorders. Both PET/CT and PET/MR hold significant promise in the field of musculoskeletal imaging, and with further radiopharmaceutical development and clinical research, these hybrid modalities can potentially transform the current management of patients with orthopedic and rheumatologic disease.

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Section: Pet/ct Versus Pet/mrimentioning

confidence: 99%

Nononcologic Applications of PET/CT and PET/MRI in Musculoskeletal, Orthopedic, and Rheumatologic Imaging: General Considerations, Techniques, and Radiopharmaceuticals

Gholamrezanezhad

Basques

Batouli

et al. 2017

J. Nucl. Med. Technol.

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“…PET imaging has proven value in cancer diagnosis, follow-up, and patient management 1,2 . It can also be used to design and adjust treatment plans in radiotherapy and chemotherapy 3 .…”

Section: Introductionmentioning

confidence: 99%

Management of respiratory motion in PET/computed tomography

Pépin¹,

Daouk²,

Bailly³

et al. 2014

Nuclear Medicine Communications

104

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Combined PET/computed tomography (CT) is of value in cancer diagnosis, follow-up, and treatment planning. For cancers located in the thorax or abdomen, the patient’s breathing causes artifacts and errors in PET and CT images. Many different approaches for artifact avoidance or correction have been developed; most are based on gated acquisition and synchronization between the respiratory signal and PET acquisition. The respiratory signal is usually produced by an external sensor that tracks a physiological characteristic related to the patient’s breathing. Respiratory gating is a compensation technique in which time or amplitude binning is used to exclude the motion in reconstructed PET images. Although this technique is performed in routine clinical practice, it fails to adequately correct for respiratory motion because each gate can mix several tissue positions. Researchers have suggested either selecting PET events from gated acquisitions or performing several PET acquisitions (corresponding to a breath-hold CT position). However, the PET acquisition time must be increased if adequate counting statistics are to be obtained in the different gates after binning. Hence, other researchers have assessed correction techniques that take account of all the counting statistics (without increasing the acquisition duration) and integrate motion information before, during, or after the reconstruction process. Here, we provide an overview of how motion is managed to overcome respiratory motion in PET/CT images.

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