Assessment of Serum Levels of the Adipocytokine Chemerin in Colorectal Cancer Patients

Alkady, Manal M; Abdel-Messeih, Phebe L; Nosseir, Neveen M.

doi:10.1515/jomb-2017-0062

Cited by 28 publications

(26 citation statements)

References 32 publications

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“…In our study, patients with a higher chemerin level had a 3-fold increased risk of developing CRA, and a significant positive correlation was observed between serum chemerin level and the number of CRA, which is a precancerous lesion of CRC [41]. Our results are consistent with those of recent reports showing that chemerin is associated with the development of CRC [26,42]. Although we could not elucidate the mechanisms underlying the role of chemerin in the development of CRA, these findings indicate that chemerin might have a potential role in the progression of colorectal tumorigenesis.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, chemerin may be a potential biomarker of malignant diseases, such as gastric cancer [25]. A recent report has shown that the circulating chemerin levels of patients with CRC are higher, and it gradually increases with the progression of TNM stage [26]. However, only a few reports have elucidated the re-lationship between chemerin levels and CRC.…”

Section: Introductionmentioning

confidence: 99%

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Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men

et al. 2019

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Background: Obesity and metabolic syndrome are considered the risk factors of colorectal adenoma (CRA) and colorectal cancer (CRC). Chemerin is a novel adipocytokine associated with the development of gastric cancer, esophageal cancer, hepatocellular carcinoma, and CRC. However, the relationship between chemerin levels and CRA remains unclear. Objective: This study is aimed at investigating the association between serum chemerin levels and the development of CRA. Methods: We conducted a total colonoscopy-based cross-sectional case-control study of 80 male patients with CRA and 80 male age-matched control individuals without CRA, according to their endoscopic findings. Serum chemerin concentrations were measured using a sandwich enzyme-linked immunosorbent assay kit, and the OR of CRA was calculated via logistic regression analysis. Results: The mean serum chemerin level of the CRA group was significantly higher than that of the control group (7.9 ± 0.41 vs. 5.16 ± 0.34 ng/mL, p < 0.001). Serum chemerin level was positively correlated to the development of CRA (r = 0.34). Multivariate logistic regression analysis revealed that a high chemerin level was independently associated with the development of CRA (OR 2.82, 95% CI 1.39-5.72). Conclusions: Our findings indicated that increased serum chemerin levels are positively associated with the presence of CRA in men. Chemerin may play an important role in the development of CRA.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men

et al. 2019

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“…Among the early diagnostic tools that have become available in recent years, serum chemerin levels have been identified as an effective biomarker for colorectal cancer. A study in 2018 compared 32 colorectal cancer patients with sex, BMI, and age matched healthy volunteers and reported that chemerin was significantly upregulated in serum of colorectal cancer patients, increasing with higher tumor stage progression ( 58 ). The area under the receiver operating characteristic (ROC) curve for serum chemerin levels was 1, with a sensitivity and specificity of 100% ( 58 ).…”

Section: Cancersmentioning

confidence: 99%

“…A study in 2018 compared 32 colorectal cancer patients with sex, BMI, and age matched healthy volunteers and reported that chemerin was significantly upregulated in serum of colorectal cancer patients, increasing with higher tumor stage progression ( 58 ). The area under the receiver operating characteristic (ROC) curve for serum chemerin levels was 1, with a sensitivity and specificity of 100% ( 58 ). The results clearly indicated that serum chemerin could be an effective biomarker for colorectal cancer and stage progression.…”

Section: Cancersmentioning

confidence: 99%

Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention

2018

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Chemerin [RARRES2 [retinoic acid receptor responder 2], TIG2 [tazarotene induced gene 2 (TIG2)]] is a multifunctional cytokine initially described in skin cultures upon exposure to the synthetic retinoid tazarotene. Its secreted pro-form, prochemerin, is widely expressed, found systemically, and is readily converted into active chemerin by various proteases. Subsequent studies elucidated major roles of chemerin as both a leukocyte chemoattractant as well as an adipokine. Chemerin's main chemotactic receptor, the G-protein coupled receptor CMKLR1, is expressed on macrophages, dendritic, and NK cells. With respect to its role in immunology, chemerin mediates trafficking of these cells to sites of inflammation along its concentration gradient, and likely helps coordinate early responses, as it has been shown to have antimicrobial and angiogenic properties, as well. Recently, there has been mounting evidence that chemerin is an important factor in various cancers. As with its role in immune responses—where it can act as both a pro- and anti-inflammatory mediator—the potential functions or correlations chemerin has in or with cancer appears to be context dependent. Most studies, however, suggest a downregulation or loss of chemerin/RARRES2 in malignancies compared to the normal tissue counterparts. Here, we perform a comprehensive review of the literature to date and summarize relevant findings in order to better define the roles of chemerin in the setting of the tumor microenvironment and tumor immune responses, with an ultimate focus on the potential for therapeutic intervention.

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“…Recent studies indicated anti-inflammatory effects of vaspin and omentin in obesity and insulin resistance conditions (20)(21)(22). Vaspin, a member of the serine protease inhibitor family, is an insulin-sensitizing adipokine which upregulated in metabolic diseases to compensate insulin resistance and inflammatory complication and furthermore may play an in hibition role in brosis development and progression (23,24). This observation suggested the possible contribution of vaspin in liver brogenesis (25).…”

Section: Discussionmentioning

confidence: 96%

Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

Aliasghari¹,

Izadi²,

Jabbari³

et al. 2018

Journal of Medical Biochemistry

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Summary Background: Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of insulin resistance, is the most common cause of chronic liver. The present study aimed to investigate the roles of Vaspin and omentin-1 in the NAFLD-related pathology including IR, inflammation and elevated blood pressure. Methods: This cross-sectional study was conducted among 83 NAFLD patients in Jahrom, Iran. Plasma levels of omentin-1, Vaspin, hs-CRP and IL-6 were measured. Anthropometric indices, lipid profiles, liver enzymes as well as abdominal ultrasonography were assessed. Results: Partial correlations controlling for age and sex showed significant positive correlation between Vaspin and fasting blood sugar (FBS), insulin, HOMA-IR, and hs-CRP. It has been observed that omentin negatively correlated with glucose levels. Moreover, a marginally significant association has been found between Omentin levels and systolic blood pressure (SBP). Conclusions: This study shows that Vaspin and Omentin-1 are associated with inflammation, insulin resistance and serum glucose levels in patients with NAFLD.

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Assessment of Serum Levels of the Adipocytokine Chemerin in Colorectal Cancer Patients

Cited by 28 publications

References 32 publications

Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men

Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men

Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention

Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

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