Assessment of small‐dose fentanyl and sufentanil blunting the cardiovascular responses to laryngoscopy and intubation in children

Xue, Fu Shan; Liu, Kunpeng; Liu, Yi; Xu, Yuan-Chen; Liao, Xu; Zhang, Guohua; Li, Cheng‐Wen; Yang, Quan; Sun, Haitao

doi:10.1111/j.1460-9592.2006.02162.x

Cited by 19 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are different from the one reported in the studies of Mireskandari et al (6), Ko et al (27) and Xue et al (26) studies. Our study has been focused on the hemodynamic changes following the intubation of traumatic patients with ASA classification I and II who have normal blood pressure.…”

Section: Discussioncontrasting

confidence: 99%

“…In this study, various doses of the same medication were administered. In contrast, different agents were used in our study (26). Ko et al in their study on 90 patients with age greater than 65 years old, have concluded that pretreatment with remifentanil, rather than fentanyl, is more effective in suppressing cardiovascular responses due to endotracheal intubation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison Between the Effects of Alfentanil, Fentanyl and Sufentanil on Hemodynamic Status During Rapid Sequence Intubation in the Emergency Department

et al. 2013

View full text Add to dashboard Cite

Background:Laryngoscopy and tracheal intubation lead to the alteration of hemodynamic parameters, including blood pressure and heart rate, in traumatic patients who sustain rapid sequence intubation (RSI). Various drugs such as fentanyl, alfentanil and sufentanil have been used to modify these hemodynamic responses.Objectives:The aim of the present study is to compare the effects of fentanyl, sufentanil and alfentanil in trauma patients who require RSI in the emergency department (ED).Patients and Methods:This was a randomized double-blinded study conducted on 90 patients (18-65 years old, ASA I, II), who needed intubation following trauma. The patients were randomly divided into three groups, Group I, Group II and Group III, who have received alfentanil, fentanyl and sufentanil, respectively. Heart rate, blood pressure, saturation of peripheral oxygen and end-tidal carbon dioxide were measured 5 minutes before and 3, 5 and 10 minutes after intubation, respectively. The changes of the hemodynamic parameters were compared in between groups. Data were analyzed by One-way ANOVA, General Linear Model Repeated Measure and Mauchly’s Sphericity Test. A P < 0.05 was considered statistically significant.Results:There was no significant statistical difference among groups with respect to hemodynamic parameters.Conclusions:Alfentanil, fentanyl and sufentanil can be used safely as premedication drugs for trauma patients who need intubation.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison Between the Effects of Alfentanil, Fentanyl and Sufentanil on Hemodynamic Status During Rapid Sequence Intubation in the Emergency Department

et al. 2013

View full text Add to dashboard Cite

show abstract

“…[29] Moreover, when used as part of anesthesia induction with propofol in children, sufentanil 0.2 μg/kg 2 min before induction was effective in attenuating the cardiovascular intubation response. [30]…”

Section: Discussionmentioning

confidence: 99%

The optimal effect-site concentration of sufentanil for laryngeal mask insertion during induction with target-controlled propofol infusion at 4.0 μg/mL

Al-Metwalli

2014

Saudi J Anaesth

View full text Add to dashboard Cite

Objective:The objective of this study is to determine the optimal effect-site concentration (Ce) of sufentanil for satisfactory insertion of laryngeal mask airway (LMA) when administered with a target-controlled infusion (TCI) of propofol at 4.0 μg/mL.Materials and Methods:A total of 25 adult patients scheduled for minor elective surgery were enrolled in this study. All patients received induction with a combination of propofol and sufentanil TCI. The TCI of sufentanil was started at a target Ce of 0.1 ng/mL. After equilibrium with the plasma concentration, the TCI of propofol was initiated, targeting a preset Ce of 4.0 μg/mL. After the loss of consciousness, LMA was inserted and assessed by an experienced Anesthesiologist. The Ce of sufentanil for the next patient was guided by modified Dixon's up-and-down method using 0.05 ng/mL as a step size. The Ce of sufentanil required for successful LMA insertion in 50% of adults (EC50) was determined by calculating the midpoint concentration of all independent pairs of patients after at least seven crossover points.Results:The optimal Ce (EC50) of sufentanil for LMA insertion during propofol induction using target Ce of 4 μg/mL was 0.16 ng/mL (95% confidence interval [CI] = 0.12-0.20). There was a significant reduction in propofol induced pain score P = 0.0275 and insignificant hemodynamic changes.Conclusion:Ce of sufentanil required for successful LMA insertion in 50% of patients (EC50) using propofol target Ce of 4.0 μg/mL was 0.16 ng/mL (95% CI = 0.12-0.20) with a significant reduction in the propofol induced pain and hemodynamic stability.

show abstract

“…The timing of endotracheal intubation was decided by the anesthesiologist who was blinded to the study protocol and the MDoloris monitoring system. The research team was responsible for recording the NIPE, HR and MBP measurements immediately before and 1 min after tracheal intubation and skin incision [20]. The changes in the MBP and HR during the observation were calculated by the following formula:…”

Section: Methodsmentioning

confidence: 99%

Newborn infant parasympathetic evaluation (NIPE) as a predictor of hemodynamic response in children younger than 2 years under general anesthesia: an observational pilot study

Zhang

Wang

et al. 2019

BMC Anesthesiol

View full text Add to dashboard Cite

Background It is still unknown whether newborn infant parasympathetic evaluation (NIPE), based on heart rate variability (HRV) as a reflection of parasympathetic nerve tone, can predict the hemodynamic response to a nociception stimulus in children less than 2 years old. Methods Fifty-five children undergoing elective surgery were analyzed in this prospective observational study. Noninvasive mean blood pressure (MBP), heart rate (HR) and NIPE values were recorded just before and 1 min after general anesthesia with endotracheal intubation as well as skin incision. The predictive performance of NIPE was evaluated by receiver-operating characteristic (ROC) curve analysis. A significant hemodynamic response was defined by a > 20% increase in HR and/or MBP. Results Endotracheal intubation and skin incision caused HR increases of 22.2% (95% confidence interval [CI] 17.5–26.9%) and 3.8% (2.1–5.5%), MBP increases of 18.2% (12.0–24.4%) and 10.6% (7.7–13.4%), and conversely, NIPE decreases of 9.9% (5.3–14.4%) and 5.6% (2.1–9.1%), respectively (all P < 0.01 vs. pre-event value). Positive hemodynamic responses were observed in 32 patients (62.7%) during tracheal intubation and 13 patients (23.6%) during skin incision. The area under the ROC curve values for the ability of NIPE to predict positive hemodynamic responses at endotracheal intubation and skin incision were 0.65 (0.50–0.78) and 0.58 (0.44–0.71), respectively. Conclusions NIPE reflected nociceptive events as well as anesthestic induction in children less than 2 years undergoing general anaesthetia. Nevertheless, NIPE may not serve as a sensitive and specific predictor to changes in hemodynamics. Trial registration This study was registered on May 3, 2018 in the Chinese Clinical Trail Registry; the registration number is ( ChiCTR1800015973 ).

show abstract

Assessment of small‐dose fentanyl and sufentanil blunting the cardiovascular responses to laryngoscopy and intubation in children

Abstract: When used as part of anesthesia induction with propofol in children, sufentanil 0.2 microg x kg(-1) 2 min before induction is more effective in attenuating the cardiovascular intubation response than fentanyl 2 microg x kg(-1).

Cited by 19 publications

References 25 publications

Comparison Between the Effects of Alfentanil, Fentanyl and Sufentanil on Hemodynamic Status During Rapid Sequence Intubation in the Emergency Department

Comparison Between the Effects of Alfentanil, Fentanyl and Sufentanil on Hemodynamic Status During Rapid Sequence Intubation in the Emergency Department

The optimal effect-site concentration of sufentanil for laryngeal mask insertion during induction with target-controlled propofol infusion at 4.0 μg/mL

Newborn infant parasympathetic evaluation (NIPE) as a predictor of hemodynamic response in children younger than 2 years under general anesthesia: an observational pilot study

Contact Info

Product

Resources

About