Assessment of the (anti)genotoxicity of brown propolis extracts from Brazilian Cerrado biome in a Drosophila melanogaster model

Fernandes, Fábio Henrique; Guterres, Zaira da Rosa; Garcez, Walmir Silva; Lopes, Sávio Mestre; Corsino, Joaquim; Garcez, Fernanda Rodrigues

doi:10.1016/j.foodres.2014.02.029

Cited by 10 publications

(14 citation statements)

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“…Although sesquiterpenes are known for their wide range of biological activities, including antimicrobial and antigenotoxic activities, literature reports the induction of DNA damage by sesquiterpene-type compounds with antimicrobial properties [38] , [39] . However, the present study demonstrated that, although bearing antimicrobial activity, EOP did not show any genotoxicity at the doses tested, even after metabolization (HB cross), unlike genotoxic effects reported for some alcoholic extracts of propolis at higher concentrations [5] , [40] , [41] . These effects might be due to the complex chemical composition of crude propolis extracts, which are known to contain flavonoids and their glycosides, prenylated and non-prenylated cinnamic acid derivatives, non-volatile diterpenes, among other compounds [2] , [42] , however absent in propolis essential oils.…”

Section: Discussioncontrasting

confidence: 76%

Evaluation of mutagenic and antimicrobial properties of brown propolis essential oil from the Brazilian Cerrado biome

et al. 2015

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Section: Discussioncontrasting

confidence: 76%

Evaluation of mutagenic and antimicrobial properties of brown propolis essential oil from the Brazilian Cerrado biome

et al. 2015

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“…Different studies identified antifungal [ 33 ], immunomodulation [ 34 – 35 ], anti-ulcer [ 19 , 36 ] and anti-inflammatory [ 37 ] properties for samples of Brazilian green propolis. Fernandes et al [ 38 ] evaluated the antioxidant effects and the (anti)genotoxicity in samples of brown propolis from the Brazilian savanna. In the study performed by Wilson et al [ 39 ], the antimicrobial activity and chemical composition of 12 samples of propolis collected in different regions of the United States were evaluated.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil

et al. 2016

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The variations in the chemical composition, and consequently, on the biological activity of the propolis, are associated with its type and geographic origin. Considering this fact, this study evaluated propolis extracts obtained by supercritical extraction (SCO2) and ethanolic extraction (EtOH), in eight samples of different types of propolis (red, green and brown), collected from different regions in Brazil. The content of phenolic compounds, flavonoids, in vitro antioxidant activity (DPPH and ABTS), Artepillin C, p-coumaric acid and antimicrobial activity against two bacteria were determined for all extracts. For the EtOH extracts, the anti-proliferative activity regarding the cell lines of B16F10, were also evaluated. Amongst the samples evaluated, the red propolis from the Brazilian Northeast (states of Sergipe and Alagoas) showed the higher biological potential, as well as the larger content of antioxidant compounds. The best results were shown for the extracts obtained through the conventional extraction method (EtOH). However, the highest concentrations of Artepillin C and p-coumaric acid were identified in the extracts from SCO2, indicating a higher selectivity for the extraction of these compounds. It was verified that the composition and biological activity of the Brazilian propolis vary significantly, depending on the type of sample and geographical area of collection.

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“…Despite the great number of studies about Brazilian propolis, the chemical composition of propolis from the central-western region of Brazil has been scarcely investigated [ 4 , 19 ]. Neither the chemical composition nor the pharmacological properties of yellow Brazilian propolis have been described so far.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Chemical Composition and Biological Activity of Yellow, Green, Brown, and Red Brazilian Propolis

Machado

Mokochinski

Lira

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The chemical composition and biological activity of a sample of yellow propolis from Mato Grosso do Sul, Brazil (EEP-Y MS), were investigated for the first time and compared with green, brown, and red types of Brazilian propolis and with a sample of yellow propolis from Cuba. Overall, EEP-Y MS had different qualitative chemical profiles, as well as different cytotoxic and antimicrobial activities when compared to the other types of propolis assessed in this study and it is a different chemotype of Brazilian propolis. Absence of phenolic compounds and the presence of mixtures of aliphatic compounds in yellow propolis were determined by analysing 1H-NMR spectra and fifteen terpenes were identified by GC-MS. EEP-Y MS showed cytotoxic activity against human tumour strain OVCAR-8 but was not active against Gram-negative or Gram-positive bacteria. Our results confirm the difficulty of establishing a uniform quality standard for propolis from diverse geographical origins. The most appropriate pharmacological applications of yellow types of propolis must be further investigated.

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Assessment of the (anti)genotoxicity of brown propolis extracts from Brazilian Cerrado biome in a Drosophila melanogaster model

Cited by 10 publications

References 47 publications

Evaluation of mutagenic and antimicrobial properties of brown propolis essential oil from the Brazilian Cerrado biome

Evaluation of mutagenic and antimicrobial properties of brown propolis essential oil from the Brazilian Cerrado biome

Chemical Composition and Biological Activity of Extracts Obtained by Supercritical Extraction and Ethanolic Extraction of Brown, Green and Red Propolis Derived from Different Geographic Regions in Brazil

Comparative Study of Chemical Composition and Biological Activity of Yellow, Green, Brown, and Red Brazilian Propolis

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