Assessment of the antibiofilm and antiquorum sensing activities of  Eucalyptus globulus  essential oil and its main component 1,8-cineole against methicillin-resistant  Staphylococcus aureus  strains

Merghni, Abderrahmen; Noumi, Emira; Hadded, Ons; Dridi, Neyla; Panwar, Harsh; Ceylan, Özgür; Mastouri, Maha

doi:10.1016/j.micpath.2018.03.006

Cited by 136 publications

(89 citation statements)

References 43 publications

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“…The activity of E. gunnii EO on S. aureus was stronger than L. petersonii EO at a concentration above 0.01 µg/mL ( Table 4). The inhibitory effect of E. gunnii EO against S. aureus confirmed the capability of the EOs recovered by species belonging to the Eucalyptus genus to block the biofilm formation by this methicillin resistant strain (Junka et al, 2019); its activity was more powerful than E. globulus EO (Merghni et al, 2018). The effectiveness shown by both EOs could be taken into consideration, once again, in patient management, mainly to avoid S. aureus infections that concern the central venous, dialysis (Gahlot et al, 2014), and urinary catheters (Murugan et al, 2016), as well as arteriovenous shunts (MacRae et al, 2016) and sutures (Henry-Stanley et al, 2010).…”

Section: Biofilm and Metabolic Activity Of Biofilm Cellssupporting

confidence: 55%

Chemical Composition and Biological Activities of the Essential Oils of Leptospermum petersonii and Eucalyptus gunnii

et al. 2020

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The aim of this study was to characterize the chemical composition and to evaluate the antimicrobial and phytotoxic properties of the essential oils (EOs) obtained from leaves of Leptospermum petersonii chemotype "Variety B" and Eucalyptus gunnii, native to Australia. Geranyl acetate, γ-terpinene, geraniol, terpinolene, α-pinene, p-cimene, and linalool were the main components in L. petersonii EO, confirming also the existence of several chemotypes in such taxa; on the other hand, 1,8-cineole, trans-sabinene hydrate acetate, globulol, longicyclene, terpinolene, and camphene were present in major amounts in the E. gunnii EO. Chemical analysis of L. petersonii revealed that it belongs to the variety "B." E. gunnii EO showed good antibacterial activity, with an MIC of 0.5 and 2 µg/mL against Staphylococcus aureus, and Pectobacterium carotovorum, respectively. The activity of E. gunnii EO was stronger than L. petersonii EO, whose maximum MIC reached 5 µg/mL. E. gunnii and L. petersonii EOs were particularly effective in inhibiting the biofilm formation by S. aureus, already at a concentration of 0.01 µg/mL. The other strains were resistant to both EOs up to a dose of 0.05 µg/mL. The maximum inhibition on biofilm formed by P. carotovorum was recorded for E. gunnii EO, reaching a value of 93.12% at 1.0 µg/mL. This is the first manuscript which studies the biofilm inhibition by EOs and evaluates their effects on biofilm metabolism. Both EOs were more effective against P. carotovorum. In addition, even though L. petersonii EO 0.1 µg/mL was unable to inhibit biofilm formation by Escherichia coli, it decreased the metabolic activity of the biofilm to 78.55% compared to control; furthermore, despite it inducing a relatively low inhibition (66.67%) on biofilm formation, it markedly affected metabolic activity, which decreased to 16.09% with respect to the control. On the contrary, L. petersonii EO 0.5 µg/mL induced a 79.88% inhibition of S. aureus

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Section: Biofilm and Metabolic Activity Of Biofilm Cellssupporting

confidence: 55%

Chemical Composition and Biological Activities of the Essential Oils of Leptospermum petersonii and Eucalyptus gunnii

et al. 2020

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“…It has been reported that 1,8-cineole has anti-inflammatory and antibacterial effects by suppressing the pathway of leukotriene B4 and prostaglandin E2 in blood mononuclear cells (Bowles 2000). Merghni et al have cited that there had been a study reporting that 1,8-cineole has a considerable level of anti-microorganism activity to gram-positive species and gram-negative ones (Merghni et al 2018). This study also confirmed the antibacterial effects of 1,8-cineole, which is a component of myrtle.…”

Section: Discussionsupporting

confidence: 77%

“…A lipophagy dissolves intercellular lipid in dead skin cells, inducing the dead skin cells to fall off. Especially, 1,8-cineole, an oxide substance, can present a synergy effect in removing dead skin cells by dissolving keratin protein (Merghni et al 2018;Battaglia 1997). With regard to the desquamation index changes, there occurred something noteworthy in week 3.…”

Section: Discussionmentioning

confidence: 99%

Effects of the myrtle essential oil on the acne skin—clinical trials for Korean women

Kim¹,

Jang

Lee

et al. 2018

biomed dermatol

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Background: This study aims to clinically verify the effects of myrtle essential oil, which has non-irritation, nontoxicity, and non-sensitivity characteristics among natural materials, by applying the oil to acne skin of Korean women, with special emphasis on a development of natural substances with a high safety to relieve acne and minimize skin irritation. Methods: After a homogeneity test was conducted targeting 20 Korean women with acne skin, who have met the primary and the secondary clinical selection criteria, the subjects were divided into the treatment group with myrtle essential oil applied (the experimental group) and the no-treatment group with no myrtle essential oil applied (the control group) to use provided cosmetics every morning and evening for 6 weeks. To precisely check the effects of the myrtle substances, the provided cosmetics are made with only a difference in the presence or absence of added myrtle substances, leaving all other substances equal. Results: The acne grades significantly decreased in the experimental group with myrtle applied, with the pore index (outstanding pores, large pores, blackheads), the erythema index, the sebum index, and the desquamation index also decreased in the group. Lastly, the microorganism index decreased considerably in the experimental group, showing all evaluation indicators related to acne improved in the experimental group in a statistically significant manner. On the other hand, the acne grades a little decreased in the control group with no myrtle applied, but with no statistical significance, while the pore index (outstanding pores, large pores, blackheads), the erythema index, the sebum index, and the desquamation index rather increased to some extent. In addition, the microorganism index decreased in the control group, but with a smaller volume of changes than that in the experimental group. Conclusion: This study has clinically proved that myrtle essential oil has effects for convergence, reduction in erythema, removal of sebum and dead skin cells, and antibacterial activity on the facial skin of Korean women. Especially, this study confirmed that myrtle essential oil is a safe, skin-soothing substance effective for treating acne by showing the oil reduced the number of erythema.

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“…For example, many virulence properties are regulated by the QS system including the synthesis of violacein in Chromobacterium violaceum ATCC 12472 [ 6 , 7 ], biofilm formation, swarming on semi-solid agar medium, production of elastase, protease and pyocyanin in the Pseudomonas aeruginosa PAO1 [ 8 ]. Several aromatic/medicinal essential oil and organic extract have been tested for their anti-QS activities [ 9 , 10 ]. A large variety of plant-derived molecules were described for their ability to interfere with the autoinducers molecules synthesized by Gram positive bacteria (AIP) and Gram negative bacteria (AHL) and attenuates the behavior of the QS-controlled virulence factors expression in both C. violaceum and P. aeruginosa PAO1 biomonitor strains [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most of these false cardamoms are used as flavoring plants and also as remedies for various ailments [ 13 ]. Elettaria cardamomum (L.) Maton is a tall, perennial, reed-like herb growing wild in rainforests of South India, Sri Lanka, and other tropical countries [ 9 , 10 ]. The plant is one of the world very ancient and expensive spices and is known as “the queen of spices” [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Biological Evaluation of Essential Oils from Cardamom Species

et al. 2018

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To highlight the importance of the spices in the Mediterranean diet, the aim of the paper was to study the essential oil compositions and to clarify the potential differences in the biological activities of the three cardamom species. In the study, we compared the phytochemical profiles and biological activities of essential oils from Elettaria cardamomum, Aframomum corrorima and Amomum subulatum. The oils were analyzed using the GC and GC/MS techniques and were mainly constituted of the oxygenated monoterpenes which represents 71.4%, 63.0%, and 51.0% of all compounds detected in E. cardamomum, A. corrorima and A. subulatum essential oils, respectively, 1,8-cineole was the main common compound between the tree tested volatile oil. The essential oils showed significant antimicrobial activity against Gram-positive and Gram-negative microorganisms tested especially the fungal strains. The Ethiopian cardamom was the most active essential oil with fungal growth inhibition zone ranging from 12.67 to 34.33 mm, MICs values ranging from 0.048 to 0.19 mg/mL, and MBCs values from 0.19 to 1.75 mg/mL. The three tested essential oils and their main component (1,8-cineole) significantly increased the production of elastase and protease production, and motility in P. aeruginosa PAO1 in a dose dependent manner. In fact, at 10 mg/mL concentration, the three essential oils showed more than 50% of inhibition of elastolytic and proteolytic activities in P. aeruginosa PAO1. The same oils inhibited also the violacein production in C. violaceum strain. It was also noticed that at high concentrations, the A. corrorima essential oil significantly inhibited the germination of radish. A thorough knowledge of the biological and safety profiles of essential oils can produce applications of economic importance.

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Assessment of the antibiofilm and antiquorum sensing activities of Eucalyptus globulus essential oil and its main component 1,8-cineole against methicillin-resistant Staphylococcus aureus strains

Cited by 136 publications

References 43 publications

Chemical Composition and Biological Activities of the Essential Oils of Leptospermum petersonii and Eucalyptus gunnii

Chemical Composition and Biological Activities of the Essential Oils of Leptospermum petersonii and Eucalyptus gunnii

Effects of the myrtle essential oil on the acne skin—clinical trials for Korean women

Chemical and Biological Evaluation of Essential Oils from Cardamom Species

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