Assessment of the Correlation between Severity of Coronary Artery Disease and Waist–Hip Ratio

Rashiti, Premtim; Behluli, Ibrahim; Bytyqi, Albiona Rashiti

doi:10.3889/oamjms.2017.211

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…In the present study, the patients with “moderate to severe” atherosclerosis had significantly higher waist/hip ratio (WHR) as compared with control groups and denoted as abdominal obesity, defined by mean level of WHR above 0.95 for males and above 0.80 for females (Lean, Han & Morrison, 1995). The previous studies have reported significant positive relationships of WHR to the presence of CAD (Rashiti, Behluli & Bytyqi, 2017) and atherosclerotic severity (Scicali et al, 2018), indicating abdominal obesity as an independent risk factor for CAD. We also demonstrated that high TG/HDL-C ratio (≥3.7) independently associated with severity of coronary atherosclerosis, by using either GS >32 or the number of vessels with 50% stenosis as an indicator.…”

Section: Discussionmentioning

confidence: 92%

Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease

Decharatchakul

Settasatian

et al. 2019

PeerJ

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Background Oxidative stress modulates insulin resistant-related atherogenic dyslipidemia: hypertriglyceridemia (HTG) and low high-density lipoprotein cholesterol (HDL-C) level. Gene polymorphisms in superoxide dismutase (SOD2 and SOD3), glutathione peroxidase-3 (GPX3), and glutathione S-transferase theta-1 (GSTT1) may enable oxidative stress-related lipid abnormalities and severity of coronary atherosclerosis. The present study investigated the associations of antioxidant-related gene polymorphisms with atherogenic dyslipidemia and atherosclerotic severity in subjects with high risk of coronary artery disease (CAD). Methods Study population comprises of 396 subjects with high risk of CAD. Gene polymorphisms: SOD2 rs4880, SOD3 rs2536512 and rs2855262, GPX rs3828599, and GSTT1 (deletion) were evaluated the associations with HTG, low HDL-C, high TG/HDL-C ratio, and severity of coronary atherosclerosis. Results SOD2 rs4880-CC, SOD3 rs2536512-AA, rs2855262-CC, and GPX3 rs3828599-AA, but not GSTT1-/- individually increased risk of HTG combined with low HDL-C level. With a combination of five risk-genotypes as a genetic risk score (GRS), GRS ≥ 6 increased risks of low HDL-C, high TG/HDL-C ratio, and HTG combined with low HDL-C, comparing with GRS 0–2 [respective adjusted ORs (95% CI) = 2.70 (1.24–5.85), 3.11 (1.55–6.23), and 5.73 (2.22–14.77)]. Gene polymorphisms, though, were not directly associated with severity of coronary atherosclerosis; high TG/HDL-C ratio was associated with coronary atherosclerotic severity [OR = 2.26 (95% CI [1.17–4.34])]. Conclusion Combined polymorphisms in antioxidant-related genes increased the risk of dyslipidemia related to atherosclerotic severity, suggesting the combined antioxidant-related gene polymorphisms as predictor of atherogenic dyslipidemia.

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Section: Discussionmentioning

confidence: 92%

Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease

Decharatchakul

Settasatian

et al. 2019

PeerJ

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“…20 Rashiti et al showed a significant positive correlation between WHR and presence of severity of CAD among Kosovar patients. 12 The study done by Siavash et al wherein they demonstrated a significant positive correlation between CAD score and WHR (p<0.01) in male patients. 21 In this study, BMI and WHR were not significantly correlated with severity of CAD.…”

Section: Discussionmentioning

confidence: 93%

“…Few studies have demonstrated correlation of BMI and WHR with severity of CAD; nonetheless, only limited data exist for an Indian population. [10][11][12][13] With this background, this study was designed to examine the correlation of BMI and WHR with severity of CAD in terms of normal coronary artery, single-vessel disease (SVD), double-vessel disease (DVD), and triple-vessel disease (TVD).…”

Section: Introductionmentioning

confidence: 99%

Correlation of body mass index and waist/hip ratio with severity of coronary artery disease

Bhatia¹,

Bhatia

Ganatara

2022

Int J Res Med Sci

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Background: Obesity assessed by body mass index (BMI) and waist/hip ratio (WHR) are better predictors of cardiovascular disease. However, there is a dearth of data investigating the correlation of BMI and WHR with severity of CAD, particularly among the Indian population. This study aims to investigate the correlation of BMI and WHR with severity of CAD assessed by angiography.Methods: This open-label observational study included patients who underwent angiography, angioplasty, or coronary artery bypass grafting in the past one month. All data such as age, gender as well as anthropometric measurements such as height (meters), weight (kg), and waist circumferences (cm), and hip circumferences (cm) were collected at the first follow-up visit. BMI (kg/m2), body surface area (BSA) (m2), and WHR were calculated. Angiography findings were retrieved from the patient’s own record to note the severity of CAD.Results: In total, 302 patients were analyzed. The mean age of the study sample was 60.5±11.5 years, and 71.9% were males. Mean BMI, BSA, and WHR were 27.0±4.3 kg/m2, 1.3±0.8 m2 and 0.96±0.07, respectively. BMI was not significantly correlated with severity of CAD (p=0.051). In both male and female patients, WHR was not significantly correlated with severity of CAD (male: p=0.256 and female: p=0.851).Conclusions: It has been concluded that BMI and WHR were not significantly correlated with severity of CAD in an Indian population.

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“…But the result showed a significant correlation between WHR and CAD (p = 0.0001). 19 On comparing WC and WHR as a marker of risk factors, the latter was found to be superior, according to most of the cross-sectional studies. 20 In the global obesity epidemic report on 1997, the WHO recommended the assessment of both BMI and WC for the determination of CVD risk and subsequent treatment strategies.…”

Section: Discussionmentioning

confidence: 99%

Association of Anthropometric Measurements with Angiographic findings among Diabetic Patients with Coronary Artery Disease

2021

jcdr

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Introduction: Obesity is one of the modifiable risk factors of diabetes mellitus (DM) and its complications viz. coronary artery disease (CAD). Scientific evidence indicates a stronger association of angiographic severity with obesity. This study aimed to compare the association of different anthropometric measurements with angiographic severity among diabetic patients with CAD and evaluate its usefulness. Methods:A cross-sectional study was conducted among 78 consecutive diabetic patients who underwent coronary angiography for suspected or known CAD of both sex aged between 35 and 65 years, with significant angiographic findings of >50% diameter stenosis. Grouping was done based on body mass index (BMI): Group I -18 to 24.9 kg/m 2 and group II -≥ 25 kg/m 2 . WC (waist circumference) > 90 cm in males and > 80 cm in females was considered as abnormal (central obesity). The anthropometric measurements included height, weight, BMI, WC, and visceral adiposity index . The Gensini scoring system was used for the assessment of the severity of CAD.Results: Among the 78 patients 57 (73%) and 21(27%) were males and females, respectively. Forty-three percent of the patients had (n=33) high BMI ≥ 25 kg/m 2 but 69.2% had abnormal WC. Gensini score was 34.9 SE 4.5640 and 36.09 SE 5.77 among group I and group II, respectively. We found a statistically significant association of WC with the number of vessels involved (P = 0.019). Conclusion:There was a significant positive association of WC with the number of vessels involved among diabetic patients with CAD.

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Assessment of the Correlation between Severity of Coronary Artery Disease and Waist–Hip Ratio

Cited by 9 publications

References 26 publications

Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease

Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease

Correlation of body mass index and waist/hip ratio with severity of coronary artery disease

Association of Anthropometric Measurements with Angiographic findings among Diabetic Patients with Coronary Artery Disease

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