Assessment of the efficacy and safety of platelet poor plasma gel as autologous dermal filler for facial rejuvenation

Abstract

Summary Background The popularity of dermal fillers has grown rapidly in the last few years for facial rejuvenation. Plasma gel is an autologous gelatinous material that is prepared from the patient's own platelet poor plasma. Objective To evaluate the clinical efficacy and safety of plasma gel injection as a dermal filler for facial rejuvenation. Patients and Methods The current study was carried out on 52 females presented with facial aging divided into two groups: Group A included 34 females with facial wrinkles, and Group B included 18 females with tear trough deformity. After taking written informed consent, they received two sessions of plasma gel injections at 2‐week interval and followed up monthly for 3 months. They were assessed clinically before treatment sessions and at the end of follow‐up period. Results Both studied groups showed immediate significant clinical improvement after plasma gel injection that maintained till the end of follow‐up period. This finding was confirmed by significant reduction in the mean values of Wrinkle Severity Rating Scale (WSRS) in Group A and Tear Trough Rating Scale (TTRS) in group B, and significant improvement of skin homogeneity and texture in both groups. In general, the reported side effects were minimal and transient. Conclusion Autologous platelet poor plasma gel injection seems to be a cost‐effective, safe, well‐tolerated, and minimally invasive technique producing significant aesthetic correction of facial wrinkles and tear trough deformity.

Erbium fractional laser irradiation combined with autologous platelet‐rich plasma and platelet‐poor plasma application for facial rejuvenation

“…The findings indicate that PRP application can attenuate the adverse reactions to minimally invasive laser irradiation and can promote the remodeling of skin collagen tissue and accelerate the healing process of wounds. In addition, as reported in other studies, PPP also has certain regenerative, reparative, and pain‐relieving effects that make it a beneficial adjuvant treatment with laser and PRP treatment . The use of PPP also ensures that no part of the patient's blood sample is wasted.…”

Platelet‐poor plasma gel vs platelet‐rich plasma for infraorbital rejuvenation: A clinical and dermoscopic comparative study

“…• Global assessment for degree of improvement 14 • Patients' satisfaction on a 0 to 3 scale 14 (0 = not satisfied at all, 1 = slightly satisfied, 2 = moderately satisfied, and 3 = very satisfied).…”

Platelet-Rich Fibrin Can Neutralize Hydrogen Peroxide-Induced Cell Death in Gingival Fibroblasts

“…Catalase, however, is a heat-sensitive protein suggesting that pasteurization of platelet products may lose their activity [21]. This aspect is relevant as heating of liquid platelet-poor plasma (PPP) is applied to prolong the resorption of albumin gels [22,23] also when preparing injectable PRF consisting of autologous albumin gel and a liquid buffy coat (Alb-PRF) [24]. The aim of this study was, therefore, to examine whether standard PRF, standard and heated PPP, as well as the buffy coat layer, could neutralize the toxic concentration of exogenous hydrogen peroxide.…”