Association analysis of interleukin-1 single nucleotide polymorphisms in viral hepatitis of Iraqi patients

Al-Saffar, Osama B.; Bajlan, Jwan S.; Ad’hiah, Ali H.

doi:10.1016/j.mgene.2019.100546

Cited by 3 publications

(1 citation statement)

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“…Interleukin‐4 (IL‐4), IL‐6, and IL‐12 are among the cytokines that are involved in immunopathogenesis of HBV and HCV infections, and some of their SNP variants have been associated with laboratory and clinical outcomes of both infections. For instance, spontaneous clearance of virus, response to vaccine and antiviral therapy, evolution of viral hepatitis, chronicity of disease, and progression of viral hepatitis to cirrhosis or hepatocellular carcinoma have been associated with certain SNPs of cytokines 13,15‐17 . However, some inconsistent observations have been made, and ethnic variations in association studies have been reported.…”

Section: Introductionmentioning

confidence: 99%

Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients

Al-Saffar

Ad’hiah

2020

Journal of Medical Virology

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Hepatitis B and C viruses (HBV and HCV) are common causative pathogens of viral hepatitis. Progression of both infections is determined by virus‐ and host‐related factors. Cytokines are important host genetic factors that may have a predisposing role in HBV and HCV infections. This case‐control study evaluated the genetic association of IL4RA+1902 (rs1801275), IL6−174 (rs1800795), IL6−597 (rs1800797), and IL12B−1188 (rs3212227) variants with chronic HBV and HCV infections among Iraqi patients. A total of 220 viral hepatitis patients were enrolled in the study (113 HBV and 107 HCV), together with 141 healthy subjects. Sequence‐specific primer polymerase chain reaction assay was the genotyping method. Results revealed that under a dominant genetic model, IL6−174 variant was significantly associated with HBV infection, whereas no association with the HCV risk was reported. However, the risk for both infections was markedly associated with IL6−597 variant under recessive, dominant, and codominant genetic models. Estimation of IL6−174‐IL6−597 haplotypes depicted that G‐A haplotype was significantly associated with an increased risk to develop HBV infection, whereas a significantly decreased risk was associated with G‐G and C‐G haplotypes. For HCV, G‐G and C‐A haplotypes were significantly associated with risk of HCV infection. IL4RA+1902 and IL12B−1188 variants showed no association with HBV or HCV risk. Analysis of variance revealed no significant association between genotypes of the four determined single‐nucleotide polymorphisms and HBV or HCV viral load. In conclusion, the study supports the concept that IL6−597 variant is associated with susceptibility to HBV and HCV infections among Iraqis. The risk of HBV infection is further associated with IL6−174 variant.

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Section: Introductionmentioning

confidence: 99%