Association between -455G/A and fibrinogen in a Chinese population

Sun, Aijun; Ma, Heng; Xu, Dazhi; Wang, Ying; Liu, Ming; Xu, Lei; Chen, Jilin; Hu, Taohong; Wang, Zhen; Wang, Keqiang; Zou, Yunzeng; Huang, Wei; Ge, Junbo

doi:10.2143/ac.64.3.2038022

Cited by 94 publications

(128 citation statements)

References 13 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…[40] In contrast to WSe 2 @CPCS, WSSe@CPCS dramatically displays the S 2p spectrum (Figure 2i), which appears with two peaks located at 161 (S 2p 3/2 ) and 163.5 eV (S 2p 1/2 ). [41] This result indicates the formation of WSSe. The Brunauer-Emmett-Teller (BET) analysis results of 3D-CPCS, WSe 2 @CPCS, and WSSe@CPCS are 582, 41, and 61 m 2 g −1 , respectively (Figure S11, Supporting Information), indicating that the specific surface area of the WSSe@CPCS has been greatly improved in the process of S doping.…”

Section: Resultsmentioning

confidence: 84%

Anion‐Vacancy Modified WSSe Nanosheets on 3D Cross‐Networked Porous Carbon Skeleton for Non‐Aqueous Sodium‐Based Dual‐Ion Storage

Lei

Wang

Cheng

et al. 2022

Small

View full text Add to dashboard Cite

Sodium‐based dual‐ion batteries (SDIBs) have become a new type of energy storage device with great application value because of their high operating voltage, high energy density, and low cost. However, transition‐metal dichalcogenide (TMD) anodes show unsatisfactory Na+ electrochemical performance owing to the low intrinsic conductivity and inferior ion transport kinetics. Here, an elaborate design is developed to prepare a composite of WSSe nanosheets supported on a 3D cross‐networked porous carbon skeleton (WSSe@CPCS), which possesses en‐rich anion vacancies and WSSe with expanded inter‐layer spacing, as well as an interconnected porous structure. As a result, the WSSe@CPCS anode for sodium‐ion batteries (SIBs) exhibits preeminent reversible capacities, excellent cycle stability, and superior rate capability. The systematic electrochemical kinetic analysis and density functional theory results further show that the effect of anion vacancies and CPCS synergistically enhances the conductivity and reduces charge transfer resistance, thus making a great contribution to fast reaction kinetics. Finally, the implementations of the WSSe@CPCS anode in progressive SIB and DIB full‐cell configurations exhibit satisfactory performance, which reveals their widely practical application. This research will provide an exciting approach to designing advanced defect‐structured tungsten‐based TMD materials for SIBs, DIBs, and even a broad range of energy storage.

show abstract

Section: Resultsmentioning

confidence: 84%

Anion‐Vacancy Modified WSSe Nanosheets on 3D Cross‐Networked Porous Carbon Skeleton for Non‐Aqueous Sodium‐Based Dual‐Ion Storage

Lei

Wang

Cheng

et al. 2022

Small

View full text Add to dashboard Cite

show abstract

“…Melanization is an important physiological process in insects that plays an important role in wound healing, cuticle tanning, immunity and so on (Nakhleh et al, 2017). Tryp and TLP are important enzymes in the process of melanization, and they have been reported to participate in immune defense reactions in a variety of animals (Zhou et al, 2012;Sun et al, 2017a;Yang et al, 2021). In E. sinensis, when Tryp was silenced, the expression of prophenoloxidase was downregulated, and the mortality rate of E. sinensis infected by S. eriocheiris increased (Gao et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The transcriptomic response of Hyphantria cunea (Drury) to the infection of Serratia marcescens Bizio based on full-length SMRT transcriptome sequencing

Zhang

Tang

Wang

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Hyphantria cunea (Drury) is a globally important forest pest. We found that the Serratia marcescens Bizio strain SM1 had insecticidal activity against H. cunea, but the transcriptomic response of H. cunea to SM1 were not clear. Therefore, we performed full-length sequencing of the transcriptomes of H. cunea larvae infected with SM1 and the control group. A total of 1,183 differentially expressed genes (DEGs) were identified by comparing the group infected with SM1 and the control group, including 554 downregulated genes and 629 upregulated genes. We found many downregulated genes in metabolic pathways. Furthermore, some of these downregulated genes were involved in cellular immunity, melanization, and detoxification enzymes, which showed that SM1 weakened H. cunea immunity. In addition, genes in the juvenile hormone synthesis pathway were upregulated, which was detrimental to the survival of H. cunea. This research analyzed the transcriptomic response of H. cunea to SM1 by high-throughput full-length transcriptome sequencing. The results provide useful information to explore the relationship between S. marcescens and H. cunea, and theoretical support for the application of S. marcescens and the control of H. cunea in the future.

show abstract

“…To identify severe COVID-19-related immune cell populations, we collected a large-scale PBMC scRNA-seq dataset (PBMC #2, n = 469,453 cells) containing 254 peripheral blood samples from patients with various COVID-19 severities (mild N = 109 samples, moderate N = 102 samples, and severe N = 50 samples) and 16 healthy controls 86 . The scRNA-seq dataset from the human cell landscape (HCL, n = 513,707 cells in 35 adult tissues) 87 , as well as the previously mentioned four scRNA-seq datasets (i.e., BMMC, PBMC #1, Human brain #1, and Mouse brain), were used to assess the performance of scPagwas in reducing the sparsity and technical noise.…”

Section: Scrna-seq Datasetsmentioning

confidence: 99%

Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data

Deng

Zhou

et al. 2023

Preprint

View full text Add to dashboard Cite

SummaryAdvances in single-cell RNA sequencing (scRNA-seq) techniques have accelerated functional interpretation of disease-associated variants discovered from genome-wide association studies (GWASs). However, identification of trait-relevant cell populations is often impeded by inherent technical noise and high sparsity in scRNA-seq data. Here, we developed scPagwas, a computational approach that uncovers trait-relevant cellular context by integrating pathway activation transformation of scRNA-seq data and GWAS summary statistics. scPagwas effectively prioritizes trait-relevant genes, which facilitates identification of trait-relevant cell types/populations with high accuracy in extensive simulated and real datasets. Cellular-level association results identified a novel subpopulation of naïve CD8+ T cells related to COVID-19 severity, and oligodendrocyte progenitor cell and microglia subsets with critical pathways by which genetic variants influence Alzheimer’s disease. Overall, our approach provides new insights for the discovery of trait-relevant cell types and improves the mechanistic understanding of disease variants from a pathway perspective.

show abstract

Association between -455G/A and fibrinogen in a Chinese population

Cited by 94 publications

References 13 publications

Anion‐Vacancy Modified WSSe Nanosheets on 3D Cross‐Networked Porous Carbon Skeleton for Non‐Aqueous Sodium‐Based Dual‐Ion Storage

Anion‐Vacancy Modified WSSe Nanosheets on 3D Cross‐Networked Porous Carbon Skeleton for Non‐Aqueous Sodium‐Based Dual‐Ion Storage

The transcriptomic response of Hyphantria cunea (Drury) to the infection of Serratia marcescens Bizio based on full-length SMRT transcriptome sequencing

Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data

Contact Info

Product

Resources

About