Association between bronchodilating response to short‐acting β‐agonist and non‐synonymous single‐nucleotide polymorphisms of β<sub>2</sub>‐adrenoceptor gene

Cho, S.-H.; Oh, Sun Young; Bahn, Jae Hoon; Choi, Joon Yul; Chang, Yoon-Seok; Kim, Y.-K.; Min, Kyung Up; Kim, Y.-Y.

doi:10.1111/j.1365-2222.2005.02319.x

Cited by 46 publications

(30 citation statements)

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“…Furthermore, in a study that demonstrated an association between asthma and ADAM33 in multiple populations, different SNPs were associated with asthma in each population [24]. Likewise, the Arg16Gly polymorphism in the beta 2 -adrenergic receptor (ADRB2) has been associated with bronchodilator response to albuterol in three mixed U.S. populations, one Korean population and one Puerto Rican population [31][32][33][34][35], but not in Mexican or African American populations [32,36].…”

Section: Genetic Risk Factors For Asthmamentioning

confidence: 99%

Race, Ethnicity and Social Class and the Complex Etiologies of Asthma

2008

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SummaryAsthma is a common but complex respiratory disease caused by the interaction of genetic and environmental factors. Significant racial and ethnic disparities in prevalence, mortality, and drug response have been described. These disparities may be explained by racial and ethnic-specific variation in genetic, environmental, social and psychological risk factors. In addition, race, ethnicity, and social class are important proxies for unmeasured factors that influence health outcomes. Herein, we review salient differences in the etiologies of asthma by race, ethnicity and social class, and argue for their continued use as variables in asthma research.

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Section: Genetic Risk Factors For Asthmamentioning

confidence: 99%

Race, Ethnicity and Social Class and the Complex Etiologies of Asthma

2008

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“…In a previous study, increased adrenoceptor downregulation was found to be related to the ADRB2 46A>G polymorphism [33]. However, previous studies failed to find significant associations between the Gln27Glu or Arg16Gly ADRB2 polymorphisms and total serum IgE levels in the Korean population [15,34,35]. In terms of specific IgE sensitization, Llanes et al [36] demonstrated no significant association between genetic variations of ADRB2 46A>G polymorphisms and the risk of olive pollen sensitization and asthma.…”

Section: Discussionmentioning

confidence: 98%

Genetic Polymorphisms of ADRB2 and IL10 May Be Associated with the Risk of IgE Sensitization to Digestive Powders in Exposed Medical Personnel

Lee

Kim

et al. 2010

Int Arch Allergy Immunol

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Background: It has been reported that pancreatic extracts may induce IgE-mediated respiratory allergy in medical personnel. The aim of the study was to identify genetic factors associated with IgE sensitization to digestive powders containing pancreatic extract. Methods: This case-control study was performed on 153 subjects routinely exposed to digestive powder and on 123 nonexposed controls working in Ajou University Hospital. Skin prick testing was performed using 4 commonly used digestive powders and α-amylase. Serum specific IgE levels were measured by ELISA. Three single nucleotide polymorphisms, ADRB2 46A>G, IL10 –1082A>G and IL4 –589T>C, were genotyped using the single base extension method. Results: The positive rate of serum specific IgE to digestive powder was significantly higher in the 41 (26.8%) exposed personnel with work-related respiratory symptoms than in controls (24.4 vs. 5.4%, p = 0.012). Thirty-nine (25.5%) of the 153 exposed personnel were found to have an allergy to digestive powder, as determined by a positive skin prick test and/or a high serum specific IgE level to digestive powder. The ADRB2 46A>G and IL10 –1082A>G polymorphisms were found to be significantly associated with the development of an allergy to digestive powder in exposed medical personnel by multiple logistic regression analysis after controlling for age, atopy and job type (pharmacist or nurse; p = 0.035 and p = 0.027, respectively). Conclusion: These results suggest that the genetic polymorphisms ADRB2 46A>G and IL10 –1082A>G are genetic factors that increase IgE sensitization to pancreatic extracts in medical personnel occupationally exposed to digestive powders.

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“…Finally, there is evolving evidence that genetic variation in the β 2 -receptor influences bronchodilator response to both short-and long-acting β 2 -agonist drugs. 27 Patients with specific β 2 -adrenoreceptors appear to respond less favourably to traditional β 2 -agonists; and may also represent a group that may benefit from alternative bronchodilators.…”

Section: Discussionmentioning

confidence: 99%

Nebulized racemic epinephrine used in the treatment of severe asthmatic exacerbation: a case report and literature review

Wiebe

Rowe

2007

CJEM

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Acute asthma is a common emergency department (ED) problem that is typically treated with bronchodilators and anti-inflammatories. Nebulized selective, short-acting β-agonists, such as salbutamol, are the bronchodilators of choice in most Canadian EDs. Other important treatments in moderate-to-severe cases include systemic corticosteroids and in severe cases may include the addition of ipratropium bromide and magnesium sulfate. Despite aggressive management, some patients do not respond adequately to nebulized salbutamol. Treatment options in these patients are limited to interventions such as parenteral epinephrine, and non-invasive and mechanical ventilation (or both). Both parenteral epinephrine and mechanical ventilation have associated risks, so alternative treatments with a lower risk profile would be useful for the treatment of life-threatening asthma. The following case report describes a patient in whom nebulized racemic epinephrine was used successfully to treat severe acute asthma following failure of standard first-line therapies. RÉSUMÉ L'asthme aigu est un problème courant dans les services d'urgence que l'on traite habituellement au moyen de bronchodilatateurs et d'anti-inflammatoires. Des agonistes bêta à action brève, sélectifs et en aérosol, comme le salbutamol, sont les bronchodilatateurs de choix dans la plupart des services d'urgence du Canada. Les corticostéroïdes systémiques sont au nombre des autres traitements importants dans les cas de gravité moyenne à sévère. Dans les cas graves, on peut ajouter du bromure d'ipratropium et du sulfate de magnésium. En dépit d'une prise en charge agressive, certains patients ne répondent pas adéquatement au salbutamol en aérosol. Les choix de traitement dans ces cas sont limités aux interventions comme l'épinéphrine parentérale et la ventilation non effractive et mécanique (ou les deux). L'épinéphrine parentérale et la ventilation mécanique comportent toutes deux des risques et c'est pourquoi d'autres traitements présentant un profil de risque moins élevé seraient utiles pour traiter l'asthme qui met la vie en danger. Le rapport de cas qui suit décrit un patient chez qui on a utilisé avec succès de l'épinéphrine racémique en aérosol pour traiter une crise d'asthme aigu sévère à la suite de l'échec des thérapies de première intention habituelles.

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Association between bronchodilating response to short‐acting β‐agonist and non‐synonymous single‐nucleotide polymorphisms of β₂‐adrenoceptor gene

Abstract: Non-synonymous SNPs of ADRB2 at codons 16 and 27 is significantly associated with bronchodilating response to inhaled short acting beta-agonists.

Cited by 46 publications

References 20 publications

Race, Ethnicity and Social Class and the Complex Etiologies of Asthma

Race, Ethnicity and Social Class and the Complex Etiologies of Asthma

Genetic Polymorphisms of ADRB2 and IL10 May Be Associated with the Risk of IgE Sensitization to Digestive Powders in Exposed Medical Personnel

Nebulized racemic epinephrine used in the treatment of severe asthmatic exacerbation: a case report and literature review

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Association between bronchodilating response to short‐acting β‐agonist and non‐synonymous single‐nucleotide polymorphisms of β2‐adrenoceptor gene

Abstract: Non-synonymous SNPs of ADRB2 at codons 16 and 27 is significantly associated with bronchodilating response to inhaled short acting beta-agonists.

Cited by 46 publications

References 20 publications

Race, Ethnicity and Social Class and the Complex Etiologies of Asthma

Race, Ethnicity and Social Class and the Complex Etiologies of Asthma

Genetic Polymorphisms of ADRB2 and IL10 May Be Associated with the Risk of IgE Sensitization to Digestive Powders in Exposed Medical Personnel

Nebulized racemic epinephrine used in the treatment of severe asthmatic exacerbation: a case report and literature review

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Association between bronchodilating response to short‐acting β‐agonist and non‐synonymous single‐nucleotide polymorphisms of β₂‐adrenoceptor gene