Association between Cerebral Arterial Calcification and Brachial-Ankle Pulse Wave Velocity in Patients with Acute Ischemic Stroke

Abstract

Background/Aims: Vascular calcification is known to be associated with cardiovascular mortality, and arterial stiffness measured by pulse wave velocity is associated with major cardiovascular risk factors. The aim of the present study was to elucidate the correlation between arterial stiffness and cerebral arterial calcification. Methods: Arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), and cerebral arterial calcification, as measured by CT angiography using a 40-multidetector scanner, were examined in patients with acute ischemic stroke. Sixty-seven subjects who were free of renal disease or peripheral arterial disease were included in the analysis. Results: Univariate analysis revealed that baPWV was significantly correlated with cerebral arterial calcification (r = 0.524, p < 0.001) and age (r = 0.452, p < 0.001), and multiple linear regression analysis indicated that age and cerebral arterial calcification were independent determinants of baPWV. Conclusion: We report that increased baPWV is closely associated with the degree of cerebral arterial calcification in patients with acute ischemic stroke. Our results suggest that the severity of cerebral arterial calcification is representative of the degree of systemic arterial stiffness.

Intracranial Internal Carotid Artery Calcification: A Representative for Cerebral Artery Calcification and Association with White Matter Hyperintensities

“…Calcification was easily differentiated from contrast material by manually adjusting the window and level. The degree of arterial calcification was scored based on a modification of the method described by Erbay et al (table 1) [15], [18]. The degree of calcification in the extracranial internal carotid artery (E-ICA), extracranial vertebral artery (E-VA), intracranial internal carotid artery (I-ICA), intracranial vertebral artery (I-VA), anterior cerebral artery, middle cerebral artery, posterior cerebral artery and basilar artery were assessed.…”

Associations Between Peripheral Artery Disease and Ischemic Stroke

“…In patients with acute stroke, arterial stiffness, measured by brachial-ankle pulse wave velocity, was associated with cerebral arterial calcification on CT angiography, suggesting correlation between cerebral arterial calcification and systemic arterial stiffness. 42 Patients with TIA and those with Figure 3. Meta-analysis of the association of ABI with all-cause mortality, total cardiovascular events, stroke/TIA, and coronary heart disease (see Supplemental Table I and supplemental references).…”

“…У пациентов с острым инсультом ригид-ность стенки артерий, определяемая по скорости рас-пространения пульсовой волны между предплечьем и лодыжкой, была ассоциирована с выраженностью кальцификации церебральных артерий по данным КТ-ангиографии, что позволяет предположить нали-чие корреляционной связи между кальцификацией церебральных артерий и системной ригидностью стенок артерий [42]. В связи с этим необходимо про-ведение более тщательной визуализации мозгового и экстракраниального кровообращения у пациентов с ТИА и пациентов с инсультом и ЗПА, хотя в иссле-довании OXVASC распространенность симптомного стеноза сонных артерий была ассоциирована с нали-чием в анамнезе ЗПА, а стеноза артерий в вертебраль-но-базилярном бассейне -нет [43].…”

Association between Pulse Wave Velocity and Nerve Conduction Study in Diabetic Patients

“…baPWV is a simple method for the evaluation of vascular status and reflects the functional change of vascular wall compliance [9,10]. It is known to be a marker of arteriosclerosis, and recent studies involving baPWV have demonstrated that together with other factors, baPWV is a significant independent determinant of diabetic neuropathy [5].…”

“…However, recent studies demonstrated that intensified multifactorial intervention for vascular risk factors other than diabetes had some beneficial effect on microvascular and macrovascular complications, although the outcome of neuropathy was not assessed [8]. Pulse wave velocity (PWV) is a marker of arterial stiffness [9,10], and Yokoyama et al [5] demonstrated that diabetic neuropathy was closely associated with arterial stiffness in a study involving PWV. However, a direct relationship between peripheral nerve status of diabetic patients and PWV has not yet been investigated.…”