Association Between Chronic Periodontal Disease and Erectile Dysfunction: A Case–Control Study

Huang, Nannan; Li, Chanxiu; Sun, Wenjuan; Yang, Yuhong; Tang, Qian; Feng, Xiao-Yong

doi:10.1177/15579883221084798

Cited by 3 publications

(1 citation statement)

References 68 publications

(88 reference statements)

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“…But, the increased risk of endothelial dysfunction has been associated with high levels of inflammatory mediators such as interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-α), and IL-1. [121][122][123] TNF-α has been reported to play a key role in the induction of endothelial dysfunction. 124,125 Multiple studies have reported a reduction in TNF-α levels after successful periodontal treatment, and it is evident that significantly higher plasma levels of TNF-α were associated with moderate to severe ED owing to their known effects on the vasculature.…”

Section: Erectile Dysfunction (Ed)mentioning

confidence: 99%

Oral Biofilms and their Connection to Systemic Health

Kurtzman¹,

Horowitz

Johnson³

et al. 2022

MRAJ

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Systemic and oral health are interconnected via bacteria and their byproducts which can circulate throughout the body which are found in the oral biofilm. Oral biofilm and its associated periodontal health have not been frequently addressed in patients with systemic health issues. This is especially true for those patients who do not respond to medical treatment via their physician for systemic issues. The periodontal sulcus in the absence of clinical presence of periodontal disease (bleeding on probing, gingival inflammation) may have oral biofilm present. Periodontal reaction is dependent on the patient’s immune response to the associated bacteria and their byproducts present in the oral biofilm. Increasing evidence has emerged in recent years that are connecting oral biofilms with systemic conditions, either by initiating them or by complicating those medical conditions. Patient health needs to be considered as a whole-body system with connections that may originate in the oral cavity and have distant effects throughout the body. In order to maximize the patient’s total health, healthcare needs to be a coordination between the physician and dentist to eliminate the oral biofilm and aid in the prevention of systemic disease or minimize these effects to improve the overall patient health and their quality of life. Various systemic health areas have been associated with the bacteria in oral biofilms and their byproducts. Those include cardiovascular disease, chronic kidney disease, diabetes, pulmonary disease, prostate cancer, colon cancer, pancreatic cancer, pre-term pregnancy, erectile dysfunction, Alzheimer’s disease, and rheumatoid arthritis. This article will discuss oral biofilm, its systemic effects, and review the medical conditions associated with the oral systemic connection with an extensive review of the literature to aid in demonstrating the total body connection.

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Section: Erectile Dysfunction (Ed)mentioning

confidence: 99%

Oral Biofilms and their Connection to Systemic Health

Kurtzman¹,

Horowitz

Johnson³

et al. 2022

MRAJ

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Evaluation of bi-directional causal association between periodontal disease and erectile dysfunction: a two-sample Mendelian randomization study

He²,

Wang

et al. 2023

Clin Oral Invest

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Exploring the Association between Periodontitis and Erectile Dysfunction: A Systematic Review

Ridho,

Agustina,

Hidayati

et al. 2024

IABJ

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Background: Periodontitis (PD) remains a global public health problem. Evidence revealed that PD contributes to the development of systemic diseases, including effects on men's sexual health such as erectile dysfunction (ED). Objective: To review and explore the association between PD and ED. Methods: Following PRISMA guidelines, a systematic review of studies published in Scopus, PubMed, ScienceDirect, and Google Scholar was conducted. A comprehensive literature search until February 2024 by combining several keywords and applying eligibility criteria was performed. JBI critical appraisal checklist was employed for quality assessment. Results: A total of 15 studies involving 216,753 subjects were included. Of the 15 studies, 13 of them demonstrated a significant association between PD and ED, the other two did not. Only one study included examination of hormonal and biochemical levels. Also, one study revealed that periodontal treatment was significantly associated with improving ED. Summary: According to the findings, a significant association between PD and ED is evident. It is believed that the inflammatory processes associated with PD contributes to the emergence of ED, yet the exact underlying mechanism remains unclear. The scarcity of research and the complexity of the association between PD and ED suggest that future rigorous studies should be conducted. Additionally, dentists and general practitioners must be aware of the interconnection between these diseases, enabling them to provide comprehensive education to patients, particularly concerning the prevention and management of periodontal disease.

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Association Between Chronic Periodontal Disease and Erectile Dysfunction: A Case–Control Study

Cited by 3 publications

References 68 publications

Oral Biofilms and their Connection to Systemic Health

Oral Biofilms and their Connection to Systemic Health

Evaluation of bi-directional causal association between periodontal disease and erectile dysfunction: a two-sample Mendelian randomization study

Exploring the Association between Periodontitis and Erectile Dysfunction: A Systematic Review

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