Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

Spencer, Melanie; Hamp, Timothy J.; Reid, Robert W.; Fischer, Leslie M.; Zeisel, Steven H.; Fodor, Anthony A.

doi:10.1053/j.gastro.2010.11.049

Cited by 540 publications

(430 citation statements)

References 52 publications

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“…Choline is also important for lipid metabolism and synthesis of very-low-density lipoprotein in the liver, and insufficient levels in the diet are associated with altered gut microbial ecology and liver steatosis in mice 56 and humans 57 . In particular, low quantities of Gamma-proteobacteria and high levels of Erysipelotrichi in human faecal microbiota are associated with hepatic steatosis 57 .…”

Section: Microbial Metabolism Of Cholinementioning

confidence: 99%

Functional interactions between the gut microbiota and host metabolism

Tremaroli

Bäckhed

2012

Nature

3,698

2,516

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Carbohydrates are important sources of energy for human and microbial cells. Human enzymes cannot degrade most complex carbohydrates and plant polysaccharides. Instead, the non-digestibleThe link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are helping to show what effect the gut microbiota has on host metabolism by improving energy yield from food and modulating dietary or the host-derived compounds that alter host metabolic pathways. Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease.

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Section: Microbial Metabolism Of Cholinementioning

confidence: 99%

Functional interactions between the gut microbiota and host metabolism

Tremaroli

Bäckhed

2012

Nature

3,698

2,516

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“…Choline metabolism is mainly disrupted by 3 main bacterial phyla in the gut microbiota: Proteobacteria, Firmicutes, and Actinobacteria (130). Spencer et al (131), in a longitudinal experimental study in healthy women who consumed a rigorously controlled diet, showed that choline deficiency led to hepatic lipid accumulation. In addition, decreased amounts of Gammaproteobacteria and increased Erysipelotrichi were directly associated with elevated accumulation of hepatic fat.…”

Section: Introductionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet

Mokhtari

Gibson

Hekmatdoost

2017

Advances in Nutrition

138

100

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Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in the world, yet the pathogenesis of the disease is not well elucidated. Due to the close anatomic and functional association between the intestinal lumen and the liver through the portal system, it is speculated that the gut microbiome may play a pivotal role in the pathogenesis of NAFLD. Furthermore, diet, which can modulate the gut microbiome and several metabolic pathways involved in NAFLD development, shows a potential tripartite relation between the gut, diet, and the liver. In this review, we summarize the current evidence that supports the association between NAFLD, the gut microbiome, and the role of diet. Adv Nutr 2017;8:240-52.

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“…Cardiovascular -diseased mice and microbial metabolism (WANG et al, 2011); 8. Nonalcoholic fatty liver disease-effect of choline depletion in human (SPENCER et al, 2011). 9.…”

Section: Gut Microbioma and Healthmentioning

confidence: 99%

“…Several diseases, however, are so important that they are worth including in this review, e.g., nonalcoholic fatty liver disease, which affects 30% of the USA population (SPENCER et al, 2011). The nonalcoholic fatty liver represents an association between composition of human gastrointestinal microbiome and the development of fatty liver, with choline deficiency as an additional risk for developing atherosclerosis and CVD.…”

Section: Visceral Obesitymentioning

confidence: 99%

Premature or pathological aging: longevity

Sgarbieri

Pacheco

2017

Braz. J. Food Technol.

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The main objective of this literature review was to summarize and characterize the main factors and events that may negatively influence quality of life and human longevity. The factors that act on premature aging processes are essentially the same as those of natural or healthy aging, but in a more intense and uncontrolled manner. Such factors are: 1) genetic (genome); 2) metabolic (metabolome); 3) environmental (life conditions and style, including diet). Factors 1 and 2 are more difficult to control by individuals; once depending on socioeconomic, cultural and educational conditions. Differently of environmental factors that may be totally controlled by individuals. Unfamiliarity with these factors leads to chronic and/or degenerative diseases that compromise quality of life and longevity.Keywords: Human longevity; Metabolic changes; Aging; Life quality; Diet. ResumoO principal objetivo desta revisão da literatura foi resumir e caracterizar os principais fatores e eventos que podem influenciar negativamente a qualidade de vida e a longevidade humana. Os fatores que atuam nos processos de envelhecimento prematuro são essencialmente os mesmos que aqueles relacionados ao envelhecimento saudável ou natural, mas em uma maior intensidade ou maneira descontrolada. Tais fatores são: 1) genéticos (genoma); 2) metabólicos (metaboloma); 3) ambientais (condições e estilos de vida, incluindo a alimentação). Os fatores dos itens 1 e 2 são mais difíceis de ser controlados, pois dependem das condições socioeconômicas, culturais e educacionais. Diferentemente dos fatores ambientais que podem ser controlados pelo indivíduo. A falta de familiaridade com esses fatores leva a doenças crônicas e/ou degenerativas que comprometem a qualidade de vida e a longevidade. Palavras-chave:Longevidade; Alterações metabólicas; Envelhecimento; Qualidade de vida; Alimentação.

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Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

Cited by 540 publications

References 52 publications

Functional interactions between the gut microbiota and host metabolism

Functional interactions between the gut microbiota and host metabolism

Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet

Premature or pathological aging: longevity

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