Association Between Comprehensive Nutritional Scoring System (CNSS) and Outcomes of Continuous Ambulatory Peritoneal Dialysis Patients

Yan, Xingqun; Yang, Xin; Xie, Xueping; Xiang, Shilong; Zhang, Xiaohui; Shou, Zhangfei; Chen, Jianghua

doi:10.1159/000485926

Cited by 4 publications

(4 citation statements)

References 79 publications

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“…Numerous studies confirmed malnutrition was associated with all-cause mortality in PD patients [36,37]. This study showed that AGR was positively correlated with some interrelated prognostic factors for malnutrition, including serum albumin, creatinine, and phosphorus, and negatively correlated with RDW, which has been demonstrated to be data reflecting malnutrition and inflammation, associated with an increased CVD mortality in PD patients in our previous study [38].…”

Section: Discussionsupporting

confidence: 69%

Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

et al. 2020

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Background: Albumin-globulin ratio (AGR), a variable based on serum albumin and non-albumin proteins, has been demonstrated as a predictor of mortality in patients with malignant neoplasm. The aim of this study was to evaluate the prognostic value of AGR on peritoneal dialysis (PD) patients. Methods: We retrospectively analyzed 602 incident PD patients from January 1st, 2008, to December 31st, 2017, at our center and followed them until December 31st, 2018. Kaplan-Meier curves and multivariate Cox regression models were applied to analyze the association between AGR and all-cause of mortality and cardiovascular mortality. Results: The median follow-up time was 32.17 (interquartile range = 32.80) months. During follow-up, 131 (21.8%) patients died, including 57 patients (43.5%) who died due to cardiovascular diseases. Kaplan-Meier curves showed that patients with AGR > 1.26 had better rates of survival than those with AGR ≤ 1.25 (p < 0.001). After adjusting for potential confounders, the lower AGR level was significantly associated with an increased all-cause and cardiovascular mortality [hazard ratio (HR): 1.57, 95% confidence interval (CI): 1.07-2.32, p = 0.022 and HR: 2.01, 95% CI: 1.10-3.69, p = 0.023 respectively]. Conclusions: Patients with a low AGR level had an increased all-cause and cardiovascular mortality. AGR may be a useful index in identifying patients on PD at risk for CVD and all-cause of mortality.

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Section: Discussionsupporting

confidence: 69%

Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

et al. 2020

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“…All variables incorporated in the prediction rule (age, sex, serum Cr, serum albumin, total cholesterol, and weekly renal Kt/V) are associated with PEW [12, 26, 30–35], emphasizing a strong association between PEW and the risk of infectious disease-related death. It has been well established that malnutrition is associated with all-cause, cardiovascular, and infection-related mortality in patients undergoing PD [10, 36].…”

Section: Discussionmentioning

confidence: 99%

Development of a risk prediction model for infection-related mortality in patients undergoing peritoneal dialysis

Tsujikawa¹,

Tanaka²,

Matsukuma³

et al. 2019

PLoS ONE

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BackgroundAssessment of infection-related mortality remains inadequate in patients undergoing peritoneal dialysis. This study was performed to develop a risk model for predicting the 2-year infection-related mortality risk in patients undergoing peritoneal dialysis.MethodsThe study cohort comprised 606 patients who started and continued peritoneal dialysis for 90 at least days and was drawn from the Fukuoka Peritoneal Dialysis Database Registry Study in Japan. The patients were registered from 1 January 2006 to 31 December 2016 and followed up until 31 December 2017. To generate a prediction rule, the score for each variable was weighted by the regression coefficients calculated using a Cox proportional hazard model adjusted by risk factors for infection-related mortality, including patient characteristics, comorbidities, and laboratory data.ResultsDuring the follow-up period (median, 2.2 years), 138 patients died; 58 of them of infectious disease. The final model for infection-related mortality comprises six factors: age, sex, serum albumin, serum creatinine, total cholesterol, and weekly renal Kt/V. The incidence of infection-related mortality increased linearly with increasing total risk score (P for trend <0.001). Furthermore, the prediction model showed adequate discrimination (c-statistic = 0.79 [0.72–0.86]) and calibration (Hosmer–Lemeshow test, P = 0.47).ConclusionIn this study, we developed a new model using clinical measures for predicting infection-related mortality in patients undergoing peritoneal dialysis.

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“…[ 1 ] However, its home-based nature can lead to low compliance among CAPD patients, which can affect treatment outcomes. [ 2 ] Additionally, recent studies have shown that dialysis patients have a much higher incidence of cognitive impairment than the general population. [ 3 ] However, the pathogenesis and risk factors of cognitive impairment in these patients are not yet fully understood, and there is a lack of epidemiological data.…”

Section: Introductionmentioning

confidence: 99%

Exploring the impact of cognitive impairments on treatment compliance and quality of life in patients with Continuous Ambulatory Peritoneal Dialysis (CAPD)

Wu,

Yu,

et al. 2023

Medicine

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The aim of this study is to investigate the impact of cognitive impairments on treatment compliance and quality of life in patients with Continuous Ambulatory Peritoneal Dialysis (CAPD). A cross-sectional study was conducted among patients with CAPD at the Department of Nephrology, Lianshui People’s Hospital from October 2021 to May 2022. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), and the End-Stage Renal Disease Adherence Questionnaire was used to evaluate treatment compliance. Quality of life was assessed using the SF-36 questionnaire. Scores from all the questionnaires and demographic data were recorded. A total of 98 patients were enrolled, and the prevalence of cognitive impairment among CAPD patients was 69.39% (MoCA score < 26). Patients were divided into 2 groups: one group with normal cognitive function (MoCA score ≥ 26) and the other with cognitive impairments. There were statistically significant differences in age, dialysis age, education, urea clearance index, history of high blood pressure, and diabetes between the 2 groups (all P < .05). Patients with cognitive impairments had lower compliance levels in terms of diet fluid restriction, medication therapeutic regimens, and dialysis regimen (all P < .05). Patients with cognitive impairments also had lower quality of life scores in the dimensions of physical function, general health, social function, emotional function, and mental health (all P < .05). Cognitive impairment appears to be common among CAPD patients and may adversely affect both their treatment adherence and overall quality of life. A more comprehensive understanding of the underlying mechanisms necessitates further study.

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Association Between Comprehensive Nutritional Scoring System (CNSS) and Outcomes of Continuous Ambulatory Peritoneal Dialysis Patients

Cited by 4 publications

References 79 publications

Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

Development of a risk prediction model for infection-related mortality in patients undergoing peritoneal dialysis

Exploring the impact of cognitive impairments on treatment compliance and quality of life in patients with Continuous Ambulatory Peritoneal Dialysis (CAPD)

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