Association Between Dementia and Midlife Risk Factors: the Radiation Effects Research Foundation Adult Health Study

Abstract

Increased SBP and low milk intake in midlife were associated with VaD detected 25 to 30 years later. Early behavioral control of the risk factors for vascular disease might reduce the risk of dementia.

Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study

“…Similarly, Yamada and colleagues found that a self-assessment of physical activity (as a continuous variable) was not associated with the risk for AD and vascular dementia in older individuals (6). In the Religious Orders Study, an estimate of hours per week spent doing physical activities was not associated with incident AD or decline in cognitive function after 4 years of follow-up, despite a similar analytic design to the one employed in the current study where physical activity was divided into quartiles (7).…”

O3‐06‐06: The Projected impact of risk factor reduction on Alzheimer's disease prevalence

“…27 Given the available evidence from epidemiologic studies and RCTs, we conclude that midlife, but not late-life, hypertension is associated with an increased risk of AD and dementia. We therefore pooled results from studies of mid-life hypertension that have been included in systematic reviews [28][29][30][31][32] to calculate a weighted OR of 1.61 (95% CI: 1.16, 2.24) (Appendix 1), which was used to calculate PAR estimates for mid-life hypertension.…”

Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study

“…Diabetes is a known risk factor for vascular disorders, which, in turn, increase the risk of dementia [20]. Some studies suggested the mediating role of vascular diseases in the association of diabetes with impaired cognition or dementia [21,22], and other reports showed a synergistic effect of diabetes and vascular disease on dementia risk [23][24][25]. Alternatively, there are mechanisms that may link diabetes with dementia.…”