Association between Exposure to Air Pollution and Total Gray Matter and Total White Matter Volumes in Adults: A Cross-Sectional Study

Erickson, Lance D.; Gale, Shawn D.; Anderson, Jacqueline E.; Brown, Bruce L.; Hedges, Dawson W.

doi:10.3390/brainsci10030164

Cited by 26 publications

(16 citation statements)

References 31 publications

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“…Recent epidemiological and experimental investigations have demonstrated PM effects on myelin tracts and white matter structures. PM 2:5 exposures were associated with decreased regional white matter volumes in the corpus callosum and frontal/temporal lobes of community-dwelling older women (Chen et al 2015) and total white matter volumes in the general population (Erickson et al 2020). Experimental data demonstrated myelin changes in the hippocampal CA1 region following rodent ultrafine PM exposures (Woodward et al 2017b).…”

Section: Introductionmentioning

confidence: 99%

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Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model

Liu

Shkirkova

Lamorie‐Foote

et al. 2021

Environ Health Perspect

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Background: Exposure to ambient air pollution particulate matter (PM) is associated with increased risk of dementia and accelerated cognitive loss. Vascular contributions to cognitive impairment are well recognized. Chronic cerebral hypoperfusion (CCH) promotes neuroinflammation and blood–brain barrier weakening, which may augment neurotoxic effects of PM. Objectives: This study examined interactions of nanoscale particulate matter (nPM; fine particulate matter with aerodynamic diameter ) and CCH secondary to bilateral carotid artery stenosis (BCAS) in a murine model to produce white matter injury. Based on other air pollution interactions, we predicted synergies of nPM with BCAS. Methods: nPM was collected using a particle sampler near a Los Angeles, California, freeway. Mice were exposed to 10 wk of reaerosolized nPM or filtered air (FA) for 150 h. CCH was induced by BCAS surgery. Mice (C57BL/6J males) were randomized to four exposure paradigms: a ) FA, b ) nPM, c ) , and d ) . Behavioral outcomes, white matter injury, glial cell activation, inflammation, and oxidative stress were assessed. Results: The joint group exhibited synergistic effects on white matter injury (2.3× the additive nPM and scores) with greater loss of corpus callosum volume on T2 magnetic resonance imaging (MRI) (30% smaller than FA group). Histochemical analyses suggested potential microglial-specific inflammatory responses with synergistic effects on corpus callosum C5 immunofluorescent density and whole brain nitrate concentrations (2.1× and 3.9× the additive nPM and effects, respectively) in the joint exposure group. Transcriptomic responses (RNA-Seq) showed greater impact of than individual additive effects, consistent with changes in proinflammatory pathways. Although nPM exposure alone did not alter working memory, the cohort demonstrated impaired working memory when compared to the group. Discussion: Our data suggest that nPM and CCH contribute to white matter injury in a synergistic manner in a mouse model. Adverse neurological effects may be aggravated in a susceptible population exposed to air pollution. https://doi.org/10.1289/EHP8792

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Section: Introductionmentioning

confidence: 99%

“…

exposures were associated with decreased regional white matter volumes in the corpus callosum and frontal/temporal lobes of community-dwelling older women ( Chen et al. 2015 ) and total white matter volumes in the general population ( Erickson et al. 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model

Liu

Shkirkova

Lamorie‐Foote

et al. 2021

Environ Health Perspect

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“…2021 ). Some other health effects of air pollution appear to vary by socioeconomic status ( Forastiere et al. 2007 ; Laurent et al.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature

Weuve

Bennett

Ranker

et al. 2021

Environ Health Perspect

115

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Background: Dementia is a devastating neurologic condition that is common in older adults. We previously reviewed the epidemiological evidence examining the hypothesis that long-term exposure to air pollution affects dementia risk. Since then, the evidence base has expanded rapidly. Objectives: With this update, we collectively review new and previously identified epidemiological studies on air pollution and late-life cognitive health, highlighting new developments and critically discussing the merits of the evidence. Methods: Using a registered protocol (PROSPERO 2020 CRD42020152943), we updated our literature review to capture studies published through 31 December 2020, extracted data, and conducted a bias assessment. Results: We identified 66 papers (49 new) for inclusion in this review. Cognitive level remained the most commonly considered outcome, and particulate matter (PM) remained the most commonly considered air pollutant. Since our prior review, exposure estimation methods in this research have improved, and more papers have looked at cognitive change, neuroimaging, and incident cognitive impairment/dementia, though methodological concerns remain common. Many studies continue to rely on administrative records to ascertain dementia, have high potential for selection bias, and adjust for putative mediating factors in primary models. A subset of 35 studies met strict quality criteria. Although high-quality studies of fine particulate matter with aerodynamic diameter ( ) and cognitive decline generally supported an adverse association, other findings related to and findings related to particulate matter with aerodynamic diameter ( , , and ) were inconclusive, and too few papers reported findings with ozone to comment on the likely direction of association. Notably, only a few findings on dementia were included for consideration on the basis of quality criteria. Discussion: Strong conclusions remain elusive, although the weight of the evidence suggests an adverse association between and cognitive decline. However, we note a continued need to confront methodological challenges in this line of research. https://doi.org/10.1289/EHP8716

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“…13 Gangguan kesehatan lain yang berisiko akibat paparan PM 2,5 yaitu dapat menurunkan volume cairan serebrospinal di otak ditandai dengan keluhan nyeri kepala dengan frekuensi sering yang selanjutnya menjadi faktor risiko degenerasi saraf. 23 Oleh karena itu diperlukan strategi pengelolaan risiko untuk mengendalikan kualitas lingkungan agar risiko gangguan kesehatan dapat menurun.…”

Section: Karakteristik Risikounclassified

Karakteristik Risiko Kesehatan Non-Karsinogenik Akibat Pajanan PM2,5 di Tempat-Tempat Umum Kota Jakarta

Pangestika

Wilti

2020

Jurnal Kesehatan Lingkungan Indonesia

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Latar belakang: Jakarta merupakan salah satu kota metropolitan yang mengalami penurunan kualitas udara. Salah satu komponen udara yang berbahaya bagi kesehatan adalah Particulat Matter 2,5 (PM2,5). Berdasarkan data Air Quality Index pada Oktober 2019, kualitas udara Jakarta setara dengan konsentrasi PM2,5 sebesar 87,9 µg/m3 yang melebihi ambang batas yaitu 65 µg/m3. Tujuan penelitian ini adalah untuk menganalisis risiko non-karsinogenik akibat paparan PM2,5 di sekitar tempat-tempat umum kota Jakarta.Metode: Penelitian ini berupa penelitian deskriptif menggunakan studi Analisis Risiko Kesehatan Lingkungan (ARKL) untuk mengetahui tingkat risiko atau Risk Quotient (RQ) pajanan PM2,5 pada radius 0-20 meter setiap lokasi. Jika nilai RQ>1 maka dikategorikan tidak aman, sedangkan nilai RQ≤1 dikategorikan aman.Hasil: Konsentrasi PM2,5 di semua lokasi secara rata-rata masih di bawah baku mutu. Tingkat risiko pajanan PM2,5 berdasarkan perhitungan asupan atau intakedibandingkan dengan hasil analisis dosis-respon rata-rata dikategorikan aman terutama di masjid dan taman kota. Sedangkan di lokasi lainnya memiliki tingkat risiko pajanan yang dikategorikan tidak aman pada radius 10 meter dari pintu masuk stasiun, titik awal di pintu masuk terminal, dan radius 10 meter dari pintu gerbang sekolah yang memiliki nilai RQ>1 tertinggi.Simpulan: Beberapa tempat umum masih memiliki risiko tidak aman akibat pajanan PM2,5 terhadap gangguan kesehatan, sehingga strategi pengelolaan diperlukan untuk menurunkan risiko gangguan kesehatan pada masyarakat dan peningkatan kualitas udara. ABSTRACTTitle: Health Risks Assessmet for Non-Carcinogenic PM2,5 Exposure in Public Places in JakartaBackground: Jakarta is a metropolitan city that has experienced a decline in air quality. One component of air that is harmful is Particulat Matter 2,5 (PM2,5). Based on Air Quality Index data in October 2019, Jakarta's air quality is equivalent to a PM2,5 oncentration of 87,9 μg/m3 which exceeds the threshold of 65 μg / m3. The purpose of this study is to analyze the non-carcinogenic risk due to PM2,5 exposure around public places in the city of Jakarta.Method: This research is a descriptive study using the Environmental Health Risk Analysis (EHRA) study method to determine the level of risk or Risk Quotient (RQ) of PM2.5 exposure at 0-20 meters in each location.. If the value of RQ> 1 is categorized as unsafe, while the value of RQ≤1 is categorized as safe.Result: PM2.5 concentrations in all locations were on average still below the quality standard. The level of risk of PM2.5 exposure based on the calculation of intake or intake compared with the results of the average dose-response analysis is considered safe in mosques and park. Meanwhile, other locations have an exposure risk level that is categorized as unsafe at a radius of 10 meters from the station entrance, the starting point at the terminal entrance, and a radius of 10 meters from the school gate that has the highest RQ>1.Conclusion: Some public places still have an insecure risk due to PM2.5 exposure to health problems, so management strategies are needed to reduce the risk of health problems in the community and increasing air quality. ABSTRACTTitle: Health Risks Assessmet for Non-Carcinogenic PM2,5 Exposure in Public Places in JakartaBackground:Jakarta is a metropolitan city that has experienced a decline in air quality. One component of air that is harmful is Particulat Matter 2,5 (PM2,5). Based on Air Quality Index data in October 2019, Jakarta's air quality is equivalent to aPM2,5 oncentration of 87,9 μg/m3 which exceeds the threshold of 65 μg / m3. The purpose of this study is to analyze the non-carcinogenic risk due to PM2,5 exposure around public places in the city of Jakarta.Method: This research is a descriptive study using the Environmental Health Risk Analysis (EHRA) study method to determine the level of risk or Risk Quotient (RQ) of PM2.5 exposure at 0-20 meters in each location.. If the value of RQ> 1 is categorized as unsafe, while the value of RQ≤1 is categorized as safe.Result:PM2.5 concentrations in all locations were on average still below the quality standard. The level of risk of PM2.5 exposure based on the calculation of intake or intake compared with the results of the average dose-response analysis is considered safe in mosques and park. Meanwhile, other locations have an exposure risk level that is categorized as unsafe at a radius of 10 meters from the station entrance, the starting point at the terminal entrance, and a radius of 10 meters from the school gate that has the highest RQ>1.Conclusion:Some public places still have an insecure risk due to PM2.5 exposure to health problems, so management strategies are needed to reduce the risk of health problems in the community and increasing air quality.

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Association between Exposure to Air Pollution and Total Gray Matter and Total White Matter Volumes in Adults: A Cross-Sectional Study

Cited by 26 publications

References 31 publications

Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model

Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model

Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature

Karakteristik Risiko Kesehatan Non-Karsinogenik Akibat Pajanan PM2,5 di Tempat-Tempat Umum Kota Jakarta

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