Association between fasting glucose and C‐reactive protein in middle‐aged subjects

Aronson, Doron; Bartha, Peter; Zinder, Oren; Kerner, Arthur; Shitman, E.; Markiewicz, Walter; Brook, Gerald J.; Levy, Yishai

doi:10.1046/j.1464-5491.2003.01084.x

Cited by 87 publications

(67 citation statements)

References 32 publications

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“…A number of factors have consistently been associated with hs-CRP [21,22]. We collected data on body mass index (BMI), smoking, infection status, physical activity, total energy, total cholesterol, age, and gender and included these variables in analyses.…”

Section: Covariate Assessmentmentioning

confidence: 99%

Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein

Griffith

Chasan‐Taber

et al. 2008

Nutrition

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Objective: This study examined the relation between quality of dietary carbohydrate intake, as measured by glycemic index (GI) and glycemic load (GL), and serum high-sensitivity C-reactive protein (hs-CRP) levels. Methods: During a 1-y observational study, data were collected at baseline and at each quarter thereafter. GI and GL were calculated from multiple 24-h dietary recalls (24HRs), 3 randomly selected 24HRs at every quarter, with up to 15 24HRs per participant. The hs-CRP was measured in blood samples collected at baseline and each of the four quarterly measurement points. Multivariable linear mixed models were used to examine the cross-sectional and longitudinal associations of GI, GL, and hs-CRP. Results: Among 582 adult men and women with at least two measurements of diet and hs-CRP, average daily GI score (white bread ϭ 100) was 85 and average GL was 198, and average hs-CRP was 1.84 mg/L. Overall, there was no association between GI or GL and hs-CRP. Subgroup analyses revealed an inverse association between GL and hs-CRP among obese individuals (body mass index Ն30 kg/m 2 ). Conclusion: Quality of dietary carbohydrates does not appear to be associated with serum hs-CRP levels. Among obese individuals, higher dietary GL appears to be related to lower hs-CRP levels. Due to the limited number of studies on this topic and their conflicting results, further investigation is warranted.

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Section: Covariate Assessmentmentioning

confidence: 99%

Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein

Griffith

Chasan‐Taber

et al. 2008

Nutrition

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“…An association of CRP to the development of atheroscleroticdisease has been observed in experimental and epidemiological studies (Ridker et al 2000, Libby et al 2002. Recent studies have shown that elevation of CRP concentrations is an independent predictive parameter of type 2 diabetes mellitus (DM; Festa et al 2002, Freeman et al 2002, which is also strongly associated with various components of the metabolic syndrome (Frohlich et al 2000, Aronson et al 2004. A number of studies reported that serum highly sensitive CRP (hs-CRP) is negatively correlated with insulin sensitivity index (SI) and serum adiponectin in some subjects (Ouchi et al 2003, Schulze et al 2004, Yuan et al 2006.…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes

Yuan

Chen²,

Ma³

et al. 2007

Journal of Endocrinology

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C-reactive protein (CRP) is considered as one of the most sensitive markers of inflammation. The aim of the present study is to investigate the effects of CRP on the production of adiponectin in 3T3-L1 adipocytes. Northern and western blot analysis revealed that CRP treatment inhibited adiponectin mRNA expression and secretion in a dose-and time-dependent manner. Co-incubation of adipocytes with rosiglitazone and CRP decreased induction of adiponectin gene expression by rosiglitazone. However, luciferase reporter assays did not show that CRP affected the activity of w2 . 1 kb adiponectin gene promoter, which was increased by rosiglitazone alone. Pharmacological inhibition of phosphatidylinositol (PI)-3 kinase by LY294002 partially reversed inhibition of adiponectin gene expression by CRP. These results collectively suggest that CRP suppresses adiponectin gene expression partially through the PI-3 kinase pathway, and that decreased production of adiponectin might represent a mechanism by which CRP regulates insulin sensitivity.

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“…In favor with this finding, Aronson D et al (2004) reported that diagnosed diabetes with impaired fasting glucose has the highest hs-CRP compared to subjects with normal fasting glucose. The authors concluded that hs-CRP levels increased continuously from the lowest quartile of normal fasting glucose level to impaired fasting glucose (P = 0.002 for trend within the nondiabetic range of fasting glucose) and to diabetes.…”

Section: Discussionmentioning

confidence: 44%

High Sensitivity C-Reactive Protein as Atherogenic Marker Among Type 2 Diabetes

Mohieldein¹,

Hasan²,

El-Habiby³

2017

ESJ

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Background: People with type 2 diabetes are threefold affected by cardiovascular disease (CVD) compared with non-diabetics. Many studies reported the absence of traditional CVD risk factors in a substantial portion of individuals experiencing clinical vascular events. Novel risk markers for CVD are often said to add independent predictive value for risk prediction. Objective: In the present study we evaluated different CVD risk factors based on high-sensitivity C-reactive (hs-CRP) protein quartiles among diabetics and non-diabetics population. Methods: In this population-based cross-sectional study, we recruited a total of one-hundred and nine participants (64 type 2 diabetics and 45 healthy controls). Venous blood sample collected from each subject. Body weight and height were measured and body mass index (BMI) was calculated. Biochemical analytes were measured according to standard procedures. Data analyzed using SPSS software. Results: Mean serum hs-CRP levels were significantly higher among diabetics (2.3 mg/l) compared to controls (1.8 mg/l; P = 0.019). Moreover, the 3rd & 4th quartiles of hs-CRP were characterized by more frequency of diabetes as well as hypertension. The percent of participants with diabetes or hypertension seemed positively related to hs CRP concentrations. Lipid profile analysis revealed the highest levels of LDL-C and Apo B in 4th quartile hs-CRP. In addition, participants in the 4th quartile hs-CRP were characterized by the highest age, BMI, plasma glucose. However, there was no clear association between levels of hs-CRP and the HbA1c, TC, TG, HDL-C, and Apo A1.European Scientific Journal November 2017 edition Vol.13, No.33 ISSN: 1857 -7881 (Print) e -ISSN 1857 404 Conclusion: Measurement of hs-CRP in diabetic patients might provide useful information for development of atherosclerosis and cardiovascular disease and help in early intervention.

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Association between fasting glucose and C‐reactive protein in middle‐aged subjects

Cited by 87 publications

References 32 publications

Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein

Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein

C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes

High Sensitivity C-Reactive Protein as Atherogenic Marker Among Type 2 Diabetes

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