Association between fluorescent antinuclear antibodies, capillary patterns, and clinical features in scleroderma spectrum disorders

Chen, Zeyi; Silver, Richard M.; Ainsworth, Sterling K.; Dobson, Richard L.; Rust, Philip F.; Maricq, Hildegard R.

doi:10.1016/0002-9343(84)90517-5

Cited by 69 publications

(36 citation statements)

References 18 publications

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“…Moreover, each SSc autoantibody was associated with a distinct rate of microvascular damage. Previous studies were of cross-sectional design and were restricted to assessments of anti-CENP-B and anti-topo I autoantibodies (47)(48)(49).…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: A twenty‐year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis

Koenig

Fritzler

Roussin

et al. 2008

Arthritis & Rheumatism

536

371

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Objective. To identify in patients with Raynaud's phenomenon (RP) independent markers that predict progression to definite systemic sclerosis (SSc) and to determine in patients with progression to SSc the type and sequence of microvascular damage and its relationship to SSc-specific autoantibodies.Methods. Consecutive patients referred for evaluation of RP who had no definite connective tissue disease were evaluated for microvascular damage by nailfold capillary microscopy (NCM) and for anticentromere (anti-CENP-B), anti-Th/To, anti-topoisomerase I, and anti-RNA polymerase III (anti-RNAP III) autoantibodies by specific assays. Patients were studied prospectively.Results. Of the 586 patients who were followed up for 3,197 person-years, 74 (12.6%) developed definite SSc. A characteristic sequence of microvascular damage was identified, starting with enlarged capillaries, followed by capillary loss, and then by capillary telangiectases. Definite SSc was diagnosed in close temporal relationship to capillary loss. Enlarged capillaries, capillary loss, and SSc-specific autoantibodies independently predicted definite SSc. Anti-CENP-B and antiTh/To antibodies predicted enlarged capillaries; these autoantibodies and anti-RNAP III predicted capillary loss. Each autoantibody was associated with a distinct time course of microvascular damage. At followup, 79.5% of patients with 1 of these autoantibodies and abnormal findings on NCM at baseline had developed definite SSc. Patients with both baseline predictors were 60 times more likely to develop definite SSc. The data validated the proposed criteria for early SSc.Conclusion. In RP evolving to definite SSc, microvascular damage is dynamic and sequential, while SScspecific autoantibodies are associated with the course and type of capillary abnormalities. Abnormal findings on NCM at baseline together with an SSc-specific autoantibody indicate a very high probability of devel-

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Section: Discussionmentioning

confidence: 99%

Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: A twenty‐year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis

Koenig

Fritzler

Roussin

et al. 2008

Arthritis & Rheumatism

536

371

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“…In order to clarify with further aspects the reported associations between nailfold capillary abnormalities and clinical and/or laboratory features (Bredemeier et al, 2004;Caramaschi et al, 2007;Chen et al, 1984;Cutolo et al, 2004;Hofstee et al, 2009;Lovy et al, 1985;Smith et al, 2012;Sulli et al, 2012) it was decided to evaluate a large multinational group of patients with SSc such as the international multicenter cohort of the EULAR Scleroderma Trials And Research (EUSTAR) registry.…”

Section: Introductionmentioning

confidence: 99%

Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Ingegnoli

Ardoino

Boracchi

et al. 2013

Microvascular Research

104

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“…Os resultados apresentados demonstram estreita associação entre alterações capilaroscópicas, especialmente desvascularização, e extensão das lesões cutâneas na ES, conforme observado previamente (4,11,13,16,23,39) . A duração do fenômeno da Raynaud também foi significativamente associada à piora na desvascularização, independente de outras variáveis.…”

Section: Discussionunclassified

“…Achados relacionados à presença dos auto-anticorpos indicam que esses podem ser um importante fator relacionado às alterações qualitativas e quantitativas da CPU. Estudos prévios associaram a presença de anticorpos anticentrômero a um padrão capilaroscópico onde há predomínio de megacapilares (às vezes denominado padrão SD lento em razão da pouca modificação do quadro vascular em exames repetidos) (6,7,13) . Esses achados são corroborados pelo presente estudo, que observou um maior número de alças capilares gigantes em pacientes com anticorpos (30) sugere que as áreas avasculares na CPU são derivadas principalmente da ruptura, extravasamento e obliteração de alças capilares que previamente sofreram dilatação progressiva.…”

Section: Discussionunclassified

“…Diversos estudos tentaram associar a presença ou severidade de alterações capilaroscópicas com lesões em órgãos-alvo na ES, obtendo resultados variáveis (4,5,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) . Nenhum desses estudos tentou associar os achados capilaroscópicos com alterações na tomografia computadorizada de alta resolução (TCAR) pulmonar, que é um método muito mais sensível e precoce do que a radiografia de tórax para a detecção de doença intersticial pulmonar (19) .…”

Section: Introductionunclassified

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Capilaroscopia periungueal pode sugerir atividade de doença pulmonar na esclerose sistêmica

Bredemeier¹,

Xavier²,

Capobianco³

et al. 2004

Rev. Bras. Reumatol.

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Objetivo: Estudar a associação entre alterações capilaroscópicas e lesões em órgãos-alvo na esclerose sistêmica (ES). Métodos: Noventa e um pacientes com ES foram avaliados através de entrevista, exame físico, capilaroscopia periungueal (CPU), sorologia, provas de função pulmonar, cintilografia de trânsito esofágico, ecocardiografia com Doppler e tomografia computadorizada de alta resolução pulmonar (TCAR). A deleção capilar na CPU foi avaliada usando o escore de deleção vascular de Lee; consideraram-se alterações severas na CPU um escore médio de deleção ≥1 ou número médio de megacapilares por dedo ≥1 para fins de análise. Hipertensão arterial pulmonar (HAP) foi definida como pressão sistólica na artéria pulmonar ≥40 mmHg. Resultados: Pacientes com alterações capilaroscópicas severas apresentaram maior prevalência de áreas de opacidades em vidro-fosco (OVF) (P=0,016), redução da capacidade difusional pulmonar (P=0,026) e disfunção esofágica (P=0,001). HAP ocorreu somente em pacientes com alterações severas na CPU (P=0,114). Naqueles com duração de doença ≤5 anos, OVF

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Association between fluorescent antinuclear antibodies, capillary patterns, and clinical features in scleroderma spectrum disorders

Cited by 69 publications

References 18 publications

Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: A twenty‐year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis

Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: A twenty‐year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis

Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Capilaroscopia periungueal pode sugerir atividade de doença pulmonar na esclerose sistêmica

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