Association between Gasdermin A, Gasdermin B Polymorphisms and Allergic Rhinitis Amongst Jordanians

Abstract

Introduction: Gasdermin A (GSDMA) and Gasdermin B (GSDMB) have been associated with childhood and to a lesser extent with adult asthma in many populations. In this study, investigate whether there is an association between GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C) at locus 17q21.2 and risk of Allergic Rhinitis among Jordanians. Also we aimed to determine if there is an association between such polymorphisms and the IgE level. Methods: The study included 112 rhinitis patients and 111 Healthy controls. Gasdermin A (GSDMA) (rs7212938, T/G) and Gasdermin B (rs7216389, T/C) polymorphisms were genotyped using the PCR-RFLP method. Results: On the genotype level, three analysis models were applied namely co-dominant, dominant and recessive genotypes. GSDMB CC genotype was found to be significant protective effect against of allergic Rhinitis (< 0.05). cc genotype was also significantly associated with higher IGE level among the studied population. Conclusion: The GSDMB CC of homozygous minor genotype showed a protective effect against Allergic rhinitis. It also was found to be significantly associated with lower IGE level among the studied population. No association was found between GSDMA with the risk of allergic Rhinitis.

The study of GSDMB in pathogenesis of psoriasis vulgaris

“…Rs10852936 is located in a long-range chromatin interaction region, which includes genes IKZF3, ZPBP2, GSDMB, and ORMDL3. Through the review of previous literature, we found that genes IKZF3, ZPBP2, GSDMB, and ORMDL3 were expressed in lymphocytes, and were significantly associated with the onset of inflammatory and immune diseases such as juvenile asthma [5], Crohn's disease [6] and rheumatoid arthritis [7]. These diseases share some common pathogenesis with psoriasis, which is also an inflammatory and immune disease.…”