Association between groups of immunoglobulin G antibodies against periodontal microorganisms and diabetes‐related mortality

Abstract

Background: Immunoglobulin G (IgG) antibodies against periodontal microorganisms can be markers of periodontal infection because their levels rise following infection and remain elevated several years later. Methods:We evaluated the relationship between groups of IgG antibodies against 19 periodontal microorganisms and diabetes-related mortality over 27 years among participants of the National Health and Nutrition Examination Survey III (1988 to 1992) aged ≥40 years at the time of examination (N = 8,153). Results: Individuals in the highest versus lowest antibody tertiles were at 86% higher risk of dying due to diabetes-related causes in the Red-Green antibody cluster (T. forsythia, T. denticola, A. actinomycetemcomitans, E. corrodens, S. noxia, V. parvula, C. rectus) (hazard ratio [HR], 1.86; 95% CI, 1.09 to 3.20) and 55% lower in the Orange-Blue antibody cluster (E. nodatum, A. naeslundii) (HR, 0.45, 95% CI, 0.32 to 0.63) in multivariable models. In these models, individuals with diabetes at the time of examination had a 16-fold higher risk of dying due to diabetes-related causes (HR, 16.4; 95% CI,11.0 to 24.7). Conclusion:As a subset of periodontal microorganisms are associated with adverse systemic outcomes, antibody profiles may help in prediction of diabetesrelated mortality and identify subgroups of individuals among whom periodontal treatment may impact diabetes-related outcomes.

Circulating IgG antibodies to periodontal bacteria and lung cancer risk in the CLUE cohorts

“…A number of studies have assayed circulating IgG antibodies to periodontal bacteria using various techniques, such as checkerboard immunoblotting, dot blotting, and enzyme-linked immunosorbent assay, to examine the association between IgG antibodies to periodontal pathogens and risk of coronary artery disease ( 18 ), atherosclerosis and hypertension ( 19 ), diabetes ( 20 ), rheumatoid arthritis ( 21 ), chronic kidney disease ( 22 ), and Alzheimer disease ( 23 ). A history of periodontitis as well as the presence of circulating IgG antibodies to key periodontal pathogens have been associated with increased risk for various types of cancers, including pancreatic, oropharyngeal, esophageal, and colorectal cancers ( 2 ).…”

Investigating the association between periodontal disease and Alzheimer's disease: a scoping review

“…But a bidirectional mendelian randomization study invovled 117386 European patients showed that PD is not the cause of AD development [32] . And a crosssectional study showed that clusters of IgG antibodies against periodontal microorganisms did not predict AD mortality [33] . In general, the general trend of most studies investigating the cross-sectional or longitudinal association between PD and AD suggests that there is a positive correlation between these two disease processes.…”

The Association between Tannerella forsythia and the Onset of Fever in Older Nursing Home Residents: A Prospective Cohort Study

“…Bacteremia due to periodontal pathogens induce multipotent progenitors such as myeloid potential and granulocyte-macrophage progenitors, which promotes inflammation in other organs [10]. Oral inflammation has a deteriorative effect on several organ systems and increases the risk of developing systemic diseases, such as diabetes [11][12][13], cardiovascular diseases [14], low-weight birth [15], atherosclerosis [16], amyotrophic lateral sclerosis [17], and respiratory tract infection [18]. A previous case-control study demonstrated that people suffering from periodontitis had a three times higher risk for the development of hospital-acquired pneumonia compared with inpatients without periodontitis [19].…”