Association between HMW adiponectin, HMW-total adiponectin ratio and early-onset coronary artery disease in Chinese population

Wang, Ying; Zheng, Aiping; Yan, Yunsheng; Song, Fei; Kong, Qianran; Shu, Qin; Zhang, Dongying

doi:10.1016/j.atherosclerosis.2014.05.910

Cited by 29 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adiponectin is a 247-amino-acids-long protein with structural and sequence homology (43%) with tumor necrosis factor-α, and complement protein C1q Adiponectin is composed of three domains: a signal sequence located at the N-terminus, a collagen-like domain, and a globular C terminal domain [64]. In the circulation, adiponectin exists as the hexamer called low molecular weight oligomer (HMW), which is composed of four to six trimmers (the active form of adiponectin) [65]. HMW oligomers are part of the intracellular adiponectin, while within circulation, adiponectin is represented as the low molecular weight oligomers.…”

Section: Adiponectinmentioning

confidence: 99%

Genetic Markers for Coronary Artery Disease

et al. 2018

View full text Add to dashboard Cite

Coronary artery disease (CAD) and myocardial infarction (MI) are recognized as leading causes of mortality in developed countries. Although typically associated with behavioral risk factors, such as smoking, sedentary lifestyle, and poor dietary habits, such vascular phenotypes have also long been recognized as being related to genetic background. We review the currently available data concerning genetic markers for CAD in English and non-English articles with English abstracts published between 2003 and 2018. As genetic testing is increasingly available, it may be possible to identify adequate genetic markers representing the risk profile and to use them in a clinical setting.

show abstract

Section: Adiponectinmentioning

confidence: 99%

Genetic Markers for Coronary Artery Disease

et al. 2018

View full text Add to dashboard Cite

show abstract

“…[59] showed that adiponectin concentration inversely correlates with the severity of coronary artery disease assessed through the Gensini score. In their study, the HMW isoform of adiponectin showed a stronger correlation with the severity of coronary artery disease than total adiponectin did, pointing to the utility of HMW adiponectin as a potential biomarker for detecting the risk of CHD [59]. Also in type 2 diabetes mellitus (DM) patients, the C1q-adiponectin/total adiponectin ratio is a significant independent predictor of the atherosclerosis score with 72.2% sensitivity and a positive predictive value of 78.8%.…”

Section: Adiponectinmentioning

confidence: 99%

Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3

Hogaş¹,

Bîlha²,

Brănișteanu³

et al. 2017

aoms

View full text Add to dashboard Cite

Cardiovascular disease is one of the main burdens of healthcare systems worldwide. Nevertheless, assessing cardiovascular risk in both apparently healthy individuals and low/high-risk patients remains a difficult issue. Already established biomarkers (e.g. brain natriuretic peptide, troponin) have significantly improved the assessment of major cardiovascular events and diseases but cannot be applied to all patients and in some cases do not provide sufficiently accurate information. In this context, new potential biomarkers that reflect various underlying pathophysiological cardiac and vascular modifications are needed. Also, a multiple biomarker evaluation that shows changes in the cardiovascular state is of interest. This review describes the role of selected markers of vascular inflammation, atherosclerosis, atherothrombosis, endothelial dysfunction and cardiovascular fibrosis in the pathogenesis and prognosis of cardiovascular disease: the potential use of cardiotrophin-1, leptin, adiponectin, resistin and galectin-3 as biomarkers for various cardiovascular conditions is discussed.

show abstract

“…Interestingly, HMW APN has the highest binding activity, which is considered the most physiologically active form [9, 17]. HMW APN or the ratio of HMW/total APN is strongly associated with some cardiovascular and infectious diseases and could be considered sensitive biomarkers for these diseases [18–20]. Therefore, investigating the changes in the level of total and HMW APN and associated correlations with clinical parameters of HFRS is an important avenue of study.…”

Section: Introductionmentioning

confidence: 99%

Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity

Kang

Zhang

et al. 2017

Journal of Immunology Research

View full text Add to dashboard Cite

Haemorrhagic fever with renal syndrome (HFRS) is characterised by an uncontrolled immune response that causes vascular leakage. Adiponectin (APN) is an adipocytokine involved in prorevascularisation and immunomodulation. To investigate the possible effects of APN in the pathogenesis of HFRS, total and high molecular weight (HMW) APN levels in the plasma of patients with HFRS were quantified using enzyme-linked immunosorbent assay (ELISA). Compared with those in healthy controls, the plasma total and HMW APN levels in patients were elevated to different degrees from the fever onset and remained high at the convalescent phase. Consistent with these results, western blot analysis additionally showed that low molecular weight (LMW), middle molecular weight (MMW), and HMW APN levels were all elevated and contributed to the elevation of the total APN level. Importantly, sustained high levels of total and HMW APN at the convalescent phase were significantly higher in patients with critical disease than those in patients with mild or moderate disease. Moreover, total and HMW APN levels negatively correlated with white blood cell count and positively correlated with platelet count and serum albumin level. These results may provide insights into understanding the roles of total and HMW APN in the pathogenesis of HFRS.

show abstract

Association between HMW adiponectin, HMW-total adiponectin ratio and early-onset coronary artery disease in Chinese population

Cited by 29 publications

References 36 publications

Genetic Markers for Coronary Artery Disease

Genetic Markers for Coronary Artery Disease

Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3

Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity

Contact Info

Product

Resources

About