Association betweenHelicobacter pyloriInfection and Risk of Osteoporosis in Elderly Taiwanese Women with Upper Gastrointestinal Diseases: A Retrospective Patient Record Review

Abstract

Introduction. Helicobacter pylori (H. pylori) infection could lead to chronic local and systemic immune response. The resulting increase in proinflammatory cytokines could affect bone resorption and might increase the risk of osteoporosis. This study aimed to investigate the association between H. pylori infection and osteoporosis in elderly female patients with upper gastrointestinal diseases. Methods. A retrospective patient record review study was conducted in a regional teaching hospital in south Taiwan. Relevant information on female patients aged 65 and over who were diagnosed with diseases of esophagus, gastric ulcer, or duodenal ulcer during January 2008 to December 2010 were abstracted. Association between H. pylori infection and osteoporosis was evaluated using multivariate logistic regression analysis. Results. Of the 365 patients with a mean age of 77.3 years, 77 (21.1%) had H. pylori infection and 101 (27.7%) had been diagnosed with osteoporosis. Multivariate logistic regression analysis revealed that osteoporosis was significantly associated with H. pylori infection (adjusted odds ratio = 2.03, 95% confidence interval = 1.14–3.62) after adjusting for age group, body mass index group, and use of proton pump inhibitor. Conclusion. Osteoporosis was found to be associated with H. pylori infection in Taiwanese female patients with upper gastrointestinal diseases. Further studies with information on potential confounders are needed to confirm the association.

Association between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis

“…From a total of 25 articles that underwent full-length review, five studies [1][2][3][4][5] involving 1,321 participants…”

Analysis of the associations among Helicobacter pylori infection, adiponectin, leptin, and 10-year fracture risk using the fracture risk assessment tool: A cross-sectional community-based study

“…pylori strains had higher values of a urinary bone fracture biomarker. Two hospital-based studies from Japan by Asaoka et al [27,29] and 1 from Taiwan by Lin et al [28] reported an association between H . pylori infection and osteoporosis.…”

Decrease of Estradiol and Several Lifestyle Factors, but Not <b><i>Helicobacter pylori</i></b> Infection, Are Significant Risks for Osteopenia in Japanese Females

“…Some reports showed the relationship between the infection of H. pylori and osteopenia in postmenopausal or elderly women [20,21]. However, it is difficult to diagnose menopause only through an interview because the final menstrual period is diagnosed retrospectively.…”

“…Recently, a meta-analysis using 5 studies [15,18,20,21,44] from Asian countries demonstrated that H. pylori infection does not seem to be an important factor related to osteopenia [45]. However, some previous studies showed a relationship between H. pylori infection and osteoporosis [16,17,18,19,20,21]. In most of these studies, H. pylori infection was diagnosed by serum anti- H. pylori IgG antibody titers or histology.…”

“…Previous studies from Western countries have reported a null relationship between H. pylori infection and osteoporosis [14,15]. On the other hand, since Figura et al [16] reported the relationship between osteoporosis and men infected with CagA-positive H. pylori , several studies from East Asia and Japan have demonstrated a relationship between H. pylori infection and osteoporosis [17,18,19,20,21]. Thus, the relationship between H. pylori infection and osteoporosis are still controversial.…”