Association Between <i>miR-155</i>, Its Polymorphism and Ischemia-Modified Albumin in Patients with Rheumatoid Arthritis

Shaker, Olfat G.; Abdelaleem, Omayma O; Fouad, Nermeen Ahmed; Ali, Amani; Ahmed, Tarek I.; Ibrahem, Enas G; Abdelghaffar, Noha K.

doi:10.1089/jir.2019.0001

Cited by 12 publications

(21 citation statements)

References 43 publications

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“…31 In our study, we also found that the T allele distribution was associated with depressed complement in SLE and significant differences in genotype frequency and allele frequency in of RA. 33 The A allele of rs767649 was independently associated with an increased risk of diabetic retinopathy. 59 Ji et al believed that the minor allele of rs767649 in the promoter was significantly associated with an increased risk of hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…A study that observed the Egyptian rheumatoid arthritis (RA) patients revealed that a functional variant of rs767649 may be an important site for the susceptibility of RA. 33 Does a relationship between these SNPs and SLE exists? These observations prompted us to further investigate their role in SLE.…”

Section: Introductionmentioning

confidence: 99%

“…Assmann et al 32 indicate that rs767649 polymorphisms in miR‐155 are associated with protection for Type 1 diabetes mellitus. A study that observed the Egyptian rheumatoid arthritis (RA) patients revealed that a functional variant of rs767649 may be an important site for the susceptibility of RA 33 . Does a relationship between these SNPs and SLE exists?…”

Section: Introductionmentioning

confidence: 99%

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Association between genetic variants of microRNA‐21 and microRNA‐155 and systemic lupus erythematosus: A case‐control study from a Chinese population

Wang

Wei

Zhang

et al. 2022

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between genetic variants of microRNA‐21 and microRNA‐155 and systemic lupus erythematosus: A case‐control study from a Chinese population

Wang

Wei

Zhang

et al. 2022

Clinical Laboratory Analysis

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“… Xie et al (2019) have reported that miR-146a inhibits inflammatory response and myocardial injury through negative feedback of the toll-like receptor 4 (TLR4)/transcription factor nuclear factor (NF)-κB signaling pathway, whereas miR-1, miR-181, and miR-155 were shown to suppress the degree of inflammatory response in myocardial hypoxia state by regulating their target genes ( Schuttler et al, 2019 ; Xie et al, 2019 ). Furthermore, most of the published studies have proven that IAM is a pivotal inflammatory marker for multiple diseases, such as rheumatoid arthritis, transient ischemic attack, vascular disease, and so on ( Shaker et al, 2019 ; Balta, 2021 ; Li et al, 2021 ). It seems reasonable to hypothesize that miRNAs may suppress the inflammatory response to decrease IAM levels during exercise training by regulating IL-6 release.…”

Section: Discussionmentioning

confidence: 99%

Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation

Wang

Wei

et al. 2021

Front. Physiol.

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Circulating microRNAs (miRNAs) have been reported dysregulated during exercise. However, the changes of specific serum miRNAs during the 5-km run test with intensity of 51–52% maximum oxygen uptake (V̇O2max) and their association with traditional cardiovascular-related indicators remain well-characterized. Levels of miR-1, miR-21, miR-146a, miR-155, miR-181, and miR-210 were detected in 120 young subjects before and after the exercise training by quantitative reverse-transcription PCR (RT-qPCR). Besides, the levels of cardiac troponin I (cTNI), myoglobin (Myo), creatine kinase (CK), creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), ischemia-modified albumin (IMA), interleukin-6 (IL-6), and C-reactive protein (CRP) were measured and the correlation between levels of serum miRNAs and biochemical parameters was also analyzed. Compared with resting state, the serum levels of miR-1, miR-146a, miR-155, miR-181, and miR-210 were significantly increased after exercise training. Serum levels of miR-146a, miR-155, and miR-210 after exercise training were positively correlated with Myo, CK-MB, and LDH, respectively, while miR-1, miR-146a, miR-181, and miR-155 were positively correlated with the levels of IL-6. Additionally, all the five miRNAs were negatively correlated with IMA levels. The multivariate logistic regression analysis showed that high levels of miR-146a, AST, LDH, and IL-6 in serum were risk factors, while low IMA contents were a protective factor for cardiovascular adaptation during exercise. In conclusion, the dynamic changes of miRNAs under the condition of the 5-km continuous running contribute to the adaptive regulation of the cardiovascular function of the body.

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“…miR‐155 was the first proven oncogenic by a previous study and has been shown to serve as a promoter and biomarker for multiple kinds of B cell lymphoma, especially Hodgkin lymphoma . miR‐155 has been shown to contribute to other processes, including immune and inflammatory reactions, and it was discovered that ectopic miR‐155 expression could eliminate HIV in macrophages arising from monocytes . Sarkar reported that ectopic expression of miR‐155 in HepG2.2.15 cells reduced viral DNA as well as protein titre, and Su reported that miR‐155 enhances innate antiviral immunity through promoting JAK/STAT signalling pathway by targeting SOCS1 and mildly inhibits HBV infection in human hepatoma cells .…”

Section: Discussionmentioning

confidence: 99%

The microRNA‐155 mediates hepatitis B virus replication by reinforcing SOCS1 signalling–induced autophagy

Chen

Ming

et al. 2020

Cell Biochemistry & Function

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As small conserved RNAs without a coding function, microRNAs are expressed in multicellular organisms and contribute to the modulation of multiple cellular reactions, such as viral replication, as well as autophagy. microRNAs can regulate host gene expression and inhibit or reinforce hepatitis B virus (HBV) replication. Hepatic cells express miR-155 noticeably. Consequently, our study explored miR-155 modulation of HBV replication and investigated the potential mechanism involved. miR-155 was inhibited on HBV infection. miR-155 transfection remarkably reinforced HBV replication, antigen expression, and progeny secretion in HepG2215 cells. Moreover, miR-155 impaired the inhibition of the cytokine signalling 1 (SOCS1)/Akt/ mTOR axis and reinforced HepG2215 autophagy. Additionally, the autophagy inhibitor (3-MA) eliminated HBsAg secretion triggered by miR-155. Taken together, miR-155 reinforced HBV replication by reinforcing SOCS1-triggered autophagy.Significance of the study: The research studied the potential mechanism involved in HBV replication and miR-155 that miR-155 reinforces HBV replication by reinforcing the SOCS1/Akt/mTOR axis-stimulated autophagy, and therefore, it can provide medical practitioners with the inspiration that chronic HBV might be cured or improved by regulating the activation of miR-155 in cells. In the study, the experiments show that autophagy inhibitors (3-MA) counteracted miR-155 contribution to HBV replication, and it might be a practicable way to improve HBV through some therapies that can repress the autophagy in related cells. K E Y W O R D S autophagy, HBV replication, infection, miR-155, SOCS1

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Association Between miR-155, Its Polymorphism and Ischemia-Modified Albumin in Patients with Rheumatoid Arthritis

Cited by 12 publications

References 43 publications

Association between genetic variants of microRNA‐21 and microRNA‐155 and systemic lupus erythematosus: A case‐control study from a Chinese population

Association between genetic variants of microRNA‐21 and microRNA‐155 and systemic lupus erythematosus: A case‐control study from a Chinese population

Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation

The microRNA‐155 mediates hepatitis B virus replication by reinforcing SOCS1 signalling–induced autophagy

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