Association between impaired glucose metabolism and quality of life: Results from the Australian diabetes obesity and lifestyle study

Tapp, Robyn J.; Dunstan, David W.; Phillips, Pat; Tonkin, Andrew; Zimmet, Paul; Shaw, Jonathan E.

doi:10.1016/j.diabres.2006.03.012

Cited by 64 publications

(57 citation statements)

References 30 publications

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“…The authors showed that poor QoL can increase the probability of developing type 2 DM, and can also be associated with less healthy lifestyle options (2) . On the other hand, DM can cause poor QoL due to the increased symptoms of hyperglycemia and other diseases related to DM and obesity (3) .…”

Section: Diabetes Mellitus (Dm) Is a Heterogeneousmentioning

confidence: 99%

Cross-cultural adaptation and validation of the instrument Diabetes - 39 (D-39): brazilian version for type 2 diabetes mellitus patients - stage 1

Queiroz¹,

Pace

Santos

2009

Rev. Latino-Am. Enfermagem

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Section: Diabetes Mellitus (Dm) Is a Heterogeneousmentioning

confidence: 99%

Cross-cultural adaptation and validation of the instrument Diabetes - 39 (D-39): brazilian version for type 2 diabetes mellitus patients - stage 1

Queiroz¹,

Pace

Santos

2009

Rev. Latino-Am. Enfermagem

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“…33 More recently, it has been demonstrated that also the early stage of the disease, that is impaired glucose tolerance, is associated with a reduced ability to perform physical activities. 34 Finally, diabetes has a greater impact on the scales of SF-36 measuring physical health as against the mental components, and the presence of coexisting hypertension in subjects with diabetes resulted in a further significant decrease of HRQL, with an additive effect. 35 The most surprising finding of our study is the highly relevant role of measures of psychological well-being in is possible that the association we observed between binge eating and PCS can be partly mediated by the higher BMI.…”

Section: Metabolic and Psychological Correlate Of Hrql F Corica Et Almentioning

confidence: 99%

Metabolic syndrome, psychological status and quality of life in obesity: the QUOVADIS Study

et al. 2007

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Objective: We aimed to investigate the association of the clinical variables of the metabolic syndrome (MS) and psychological parameters on health-related quality of life (HRQL) in obesity. In particular, our aim was to investigate the relative impact of physical symptoms, somatic diseases and psychological distress on both the physical and the mental domains of HRQL. Design: Cross-sectional study. Subjects: A cohort of 1822 obese outpatients seeking treatment in medical centers. Measurements: HRQL was measured by the standardized summary scores for physical (PCS) and mental (MCS) components of the Short Form 36 Health Survey (SF-36). Patients were grouped according to tertiles of PCS and MCS. Metabolic and psychological profiles of PCS and MCS tertiles were compared by discriminant analysis. Results: The profile of metabolic and psychological variables was tertile-specific in 62.4 and 68.3% of patients in the lowest and highest tertiles of PCS, respectively, while concordance was low in the mid-tertile (32.8%). Concordance was very high in the lowest (74.4%) and in the highest (75.5%) tertiles of MCS, and was fair in the mid-tertile (53.2%). The main correlates of PCS were obesity-specific and general psychological well-being, BMI, body uneasiness, binge eating, gender and psychiatric distress. Only hypertension and hyperglycemia qualified as correlates among the components of MS. The components of MS did not define MCS. Conclusions: Psychological well-being is the most important correlate of HRQL in obesity, both in the physical and in the mental domains, whereas the features of MS correlate only to some extent with the physical domain of HRQL.

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“…Most scores are similar or slightly better than those reported in other populations with prediabetes. 7 …”

Section: Quality Of Life At Baselinementioning

confidence: 99%

“…A cross-sectional study examined the association of HRQoL with glucose tolerance status in an Australian population. 7 While those with previously diagnosed diabetes were at a significantly greater risk of being in the lowest quartile of each domain of the 36-Item…”

Section: Introductionmentioning

confidence: 99%

Impact of Lifestyle Intervention and Metformin on Health-Related Quality of Life: the Diabetes Prevention Program Randomized Trial

et al. 2012

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BACKGROUND: Adults at high risk for diabetes may have reduced health-related quality of life (HRQoL). OBJECTIVE: To assess changes in HRQoL after interventions aimed at diabetes risk reduction. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial, the Diabetes Prevention Program, was conducted in 27 centers in the United States, in 3,234 non-diabetic persons with elevated fasting and postload plasma glucose, mean age 51 years, mean BMI 34 Kg/m²; 68 % women, and 45 % members of minority groups. INTERVENTIONS: Intensive lifestyle (ILS) program with the goals of at least 7 % weight loss and 150 min of physical activity per week, metformin (MET) 850 mg twice daily, or placebo (PLB). MEASUREMENTS: HRQoL using the 36-Item ShortForm (SF-36) health survey to evaluate health utility index (SF-6D), physical component summaries (PCS) and mental component summaries (MCS). A minimally important difference (MID) was met when the mean of HRQoL scores between groups differed by at least 3 %. RESULTS: After a mean follow-up of 3.2 years, there were significant improvements in the SF-6D (+0.008, p=0.04) and PCS (+1.57, p<0.0001) scores in ILS but not in MET participants (+0.002 and +0.15, respectively, p=0.6) compared to the PLB group. ILS participants showed improvements in general health (+3.2, p< 0.001), physical function (+3.6, p<0.001), bodily pain (+1.9, p= 0.01), and vitality (+2.1, p= 0.01) domain scores. Treatment effects remained significant after adjusting sequentially for baseline demographic factors, and for medical and psychological comorbidities. Increased physical activity and weight reduction mediated these ILS treatment effects. Participants who experienced weight gain had significant worsening on the same HRQoL specific domains when compared to those that had treatment-related (ILS or MET) weight loss. No benefits with ILS or MET were observed in the MCS score. CONCLUSION: Overweight/obese adults at high risk for diabetes show small improvement in most physical HRQoL and vitality scores through the weight loss and increased physical activity achieved with an ILS intervention.KEY WORDS: quality of life; lifestyle; metformin; diabetes risk; weight loss.

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Association between impaired glucose metabolism and quality of life: Results from the Australian diabetes obesity and lifestyle study

Cited by 64 publications

References 30 publications

Cross-cultural adaptation and validation of the instrument Diabetes - 39 (D-39): brazilian version for type 2 diabetes mellitus patients - stage 1

Cross-cultural adaptation and validation of the instrument Diabetes - 39 (D-39): brazilian version for type 2 diabetes mellitus patients - stage 1

Metabolic syndrome, psychological status and quality of life in obesity: the QUOVADIS Study

Impact of Lifestyle Intervention and Metformin on Health-Related Quality of Life: the Diabetes Prevention Program Randomized Trial

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