Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Li, Xiaona; Xia, Qing; Fan, Dazhi; Cai, Guoqi; Yang, Xiao; Wang, Li; Xin, Lihong; Ding, Ning; Hu, Yun; Liu, Li; Xu, Shengqian; Xu, Jianhua; Wang, Kang; Pan, Faming

doi:10.1016/j.humimm.2015.06.017

Cited by 15 publications

(9 citation statements)

References 41 publications

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“…In the current study, we incorporated more studies with further ethnic populations to achieve better results. The only consistence results obtained from current meta-analysis and that of Li et al study, was 2DL3 as protective factor in RA patients [60]. While the previous meta-analysis found two positive associations of KIR genes with RA susceptibility, we found that all significantly associated KIR genes had negative association with RA risk.…”

Section: Discussioncontrasting

confidence: 71%

“…Second, the number of published studies entered in this research was relatively small which restrict the estimation power of the present study. However, considering the increased number of subjects included in this meta-analysis, the obtained results are more reliable than the previous analysis [60]. Additionally, various populations of Europe, Asia, and American nations were included in the current meta-analysis, increasing the general conclusion of the results to populations worldwide.…”

Section: Discussionmentioning

confidence: 86%

“…A meta-analysis undertaken by Li et al in 2015 to evaluate association between KIR variations and RA risk in East Asians and Caucasians subpopulations. The findings of their survey represented two positive associations, including 2DL1, 2DS1, and 2DL3 as a protective factor for RA risk only in East Asians, but not in Caucasians [60]. In the current study, we incorporated more studies with further ethnic populations to achieve better results.…”

Section: Discussionmentioning

confidence: 99%

“…While the previous meta-analysis found two positive associations of KIR genes with RA susceptibility, we found that all significantly associated KIR genes had negative association with RA risk. KIR2DL5, KIR2DS5, and KIR3DL3 conferred a protective role in RA development [60].…”

Section: Discussionmentioning

confidence: 99%

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Association study between KIR polymorphisms and rheumatoid arthritis disease: an updated meta-analysis

Aghaei¹,

Mostafaei²,

Aslani³

et al. 2019

BMC Med Genet

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BackgroundCurrently published studies investigating association between the killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and rheumatoid arthritis (RA) reported inconsistent and contradictory results. Hence, we aim to carry out this comprehensive meta-analysis of all eligible studies meeting the inclusion criteria to achieve precise and comprehensive relationships between genetic variations in KIR gene cluster and risk of RA.MethodsDatabases of Medline/PubMed and Scopus were searched to investigate case-control studies prior to May 2018. The associations between KIR gene polymorphisms and RA susceptibility were analyzed by computing the odds ratio (OR) and 95% confidence interval (95% CI) for each study.ResultsA total of 11 comparative case-control studies involving 1847 RA patients and 2409 healthy individuals were included in this meta-analysis. Four significant associations of 2DL3 (OR = 0.591, 95% CI = 0.351–0.994; P = 0.047), 2DL5 (OR = 0.716, 95% CI = 0.601–0.853; P < 0.001), 2DS5 (OR = 0.623, 95% CI = 0.393–0.988; P = 0.045), and 3DL3 (OR = 0.324, 95% CI = 0.129–0.814; P = 0.016) genes with decreased RA risk were discovered in this meta-analysis. Although, other KIR receptors including 2DL1, 2DL2, 2DL4, 3DL1, 3DL2, 3DS1, 2DS1-2DS4, and two pseudo gens of 2DP1 and 3DP1 displayed no significant association with predisposition to RA.ConclusionsThese findings provide reliable evidence that 2DL3, 2DL5, 3DL3, and 2DS5 might have a potential protective role for RA.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Association study between KIR polymorphisms and rheumatoid arthritis disease: an updated meta-analysis

Aghaei¹,

Mostafaei²,

Aslani³

et al. 2019

BMC Med Genet

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“…[34] Therefore, we performed a subgroup analysis by ethnicity to identify the origin of heterogeneity. In the subgroup analyses, the results showed that 2DL1 might be a risk factor in Caucasians but not in Asians.…”

Section: Discussionmentioning

confidence: 99%

Association between killer cell immunoglobulin-like receptor (KIR) polymorphisms and systemic lupus erythematosus (SLE) in populations

Liang

Ma²,

Tan³

2017

Medicine

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Background:Recently, a growing number of studies show that the killer cell immunoglobulin-like receptor (KIR) gene polymorphisms may play a role in the systemic lupus erythematosus (SLE) susceptibility. Nonetheless, the results were inconsistent. Thus, a meta-analysis was carried out by integrating multiple research to clarify the association between KIR polymorphisms and SLE susceptibility.Methods:The Web of Science, Embase (Ovid), PubMed, Elsevier Science Direct, the Chinese Biomedical Database and CNKI, Wanfang databases (last search was updated on May 15, 2016) were systematically searched to select studies on addressing the association between the KIR polymorphisms and susceptibility to SLE in populations. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated.Results:A total of 10 published case-control studies involving 1450 SLE patients and 1758 controls were available for this meta-analysis. Results suggested that KIR2DL1 might be a risk factor for SLE (OR 2DL1 =1.047, 95% CI=1.011–1.083) in all subjects. The KIR2DL3, KIR2DL5 were identified as protective factors for SLE in Asian populations (OR2DL3= 0.215, 95% CI = 0.077–0.598; OR2DL5 = 0.588, 95% CI = 0.393–0.881), but not in Caucasians.Conclusions:The meta-analysis results suggested that 2DL1 might be a potential risk factor and 2DL3, 2DL5 might be protective factors for SLE in Asians but not in Caucasians.

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The role of killer-cell immunoglobulin-like receptor (KIR) genes in susceptibility to inflammatory bowel disease: systematic review and meta-analysis

et al. 2018

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Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

Cited by 15 publications

References 41 publications

Association study between KIR polymorphisms and rheumatoid arthritis disease: an updated meta-analysis

Association study between KIR polymorphisms and rheumatoid arthritis disease: an updated meta-analysis

Association between killer cell immunoglobulin-like receptor (KIR) polymorphisms and systemic lupus erythematosus (SLE) in populations

The role of killer-cell immunoglobulin-like receptor (KIR) genes in susceptibility to inflammatory bowel disease: systematic review and meta-analysis

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