Association between <b><i>IL-13</i></b> Gene rs20541 Polymorphism and Glioma Susceptibility: A Meta-Analysis

Abstract

Objective: We performed a meta-analysis to estimate the association between IL-13 gene rs20541 (R130Q) polymorphism and the susceptibility of glioma. Patients and Methods: Potentially eligible studies published before February 1, 2016 were searched in 4 databases including PubMed, EMBASE, EBSCO, and Ovid. Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were used to estimate the strength of relationship between the IL-13 gene rs20541 polymorphism and glioma susceptibility. Stata 11.0 software was used to perform the present meta-analysis. Results: In total, 10 case-control studies with 13 datasets including 3,123 cases and 5,390 controls were identified. A significant increase in glioma susceptibility was found in the dominant model (AA + AG vs. GG: OR = 1.14, 95% CI 1.01-1.29; P = 0.031). Significantly decreasing glioma susceptibility was found for Asians in the heterozygote comparison (AG vs. GG: OR = 0.74, 95% CI 0.55-0.99; P = 0.042) and the allele contrast genetic model (A vs. G: OR = 0.67, 95% CI 0.47-0.96; P = 0.028). By contrast, in Caucasians, a significant increase in glioma susceptibility was found in the dominant model (AA + AG vs. GG: OR = 1.25, 95% CI 1.11-1.41; P = 0.000). Conclusion: There may be a weak association between the IL-13 gene rs20541 polymorphism and glioma susceptibility, and the associations may be different between ethnicities.

Identification of differentially expressed microRNAs and the potential of microRNA‑455‑3p as a novel prognostic biomarker in glioma

“…The prognosis of patients with glioma is relatively poor due to metastasis and recurrence (3,19). The incidence and mortality rates of glioma are continuously increasing (1). Although numerous epigenetic changes have been identified to be associated with glioma, the pathogenesis is not fully understood.…”

“…Glioma is an aggressive brain cancer with high morbidity and mortality rates (1) characterized by aggressive proliferation, invasion and dismal prognosis (2). Although great progress has been made in the therapeutic field, the prognosis of patients with glioma remains poor (3).…”

MicroRNA‑769‑3p inhibits tumor progression in glioma by suppressing ZEB2 and inhibiting the Wnt/β‑catenin signaling pathway

“…Glioma is the most common form of brain cancer (1), and the prognosis of glioma is relatively poor (2). Glioma cells infiltrate the healthy tissues surrounding the main tumor mass, limiting the survival of patients with glioma (3). Despite advances in technology and medicine, the incidence and mortality rates of glioma still continue to increase (4).…”

Polymorphic Variants of Interleukin-13 R130Q and Interleukin-4 T589C in Children with and without Cow’s Milk Allergy

“…IL-13 is known to cause alternative activation of macrophages involved in the activation of Th2 reactions [ 26 ]. To date, polymorphic variants of cytokine genes are widely studied by scientists in the context of risk factors associated with diseases such as bronchial asthma, allergic rhinitis, glioma, hepatocellular carcinoma, idiopathic nephrotic syndrome, and orthodontic pathology [ 27 , 28 , 29 ].…”

“…Thus, a meta-analysis conducted by Chinese scientists showed an association between the IL-13 rs20541 (R130Q) gene polymorphism and susceptibility to glioma, as the GA genotype was much more common in glioma patients [ 29 ]. Al Rushood et al analyzed the relationship of the IL-13 R130Q (rs20541) polymorphism to the predisposition of children to idiopathic nephrotic syndrome and found that the IL-13 RQ genotype was significantly more common in children with high sensitivity to steroid therapy than in children with steroid resistance [ 27 ].…”