Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity

Reuter, Cézane Priscila; Burgos, Míria Suzana; Bernhard, Joana Carolina; Tornquist, Débora; Klinger, Elisa Inês; Borges, Tássia Silvana; Renner, Jane Dagmar Pollo; Valim, Andréia Rosane de Moura; Mello, Elza Daniel de

doi:10.1016/j.jped.2015.11.005

Cited by 27 publications

(31 citation statements)

References 23 publications

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“…Our data show that the allelic frequencies found are similar to previous studies (8,18,19) . Minor allelic frequencies of rs9939609/A (FTO) and rs6548238/T (TMEM18) were 35 and 15 %, respectively, in other studies with Brazilian population (8,18) .…”

Section: Discussionsupporting

confidence: 92%

Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents

et al. 2018

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The prevalence of childhood obesity has increased worldwide. Although it is considered a polygenic inheritance disease, little is known about its susceptibility when the additive effect is considered. The aim of this study is to investigate whether the genetic risk score (GRS) based on previously associated obesity polymorphisms (SNP) rs9939609 (fat mass and obesity-associated (FTO)), rs6548238 (transmembrane protein 18 (TMEM18)) and rs16835198 (fibronectin type III domain containing 5 (FNDC5)) could serve as a predictor for anthropometric characteristics in a sample of Brazilian children and adolescents. This is a cross-sectional study with 1471 children and adolescents aged 6–17 years. BMI, waist circumference (WC) and percentage of body fat and metabolic parameters were verified. In all, three SNP were genotyped by TaqMan™ allelic discrimination. The metabolic and anthropometric parameters were compared between the genotypes, and the unweighted and weighted GRS (GRS and wGRS, respectively) were created to test the additive effect of these genetic polymorphisms on anthropometric parameters. The prevalence of overweight plus obesity was 41 %. Significant associations were identified for FTO rs9939609, TMEM18 rs6548238 and FNDC5 rs16835198 and for GRS and wGRS with anthropometric phenotypes. The higher score of wGRS was associated with obesity (OR: 2·65, 95 % CI 1·40, 5·04, P=0·003) and with greater WC (OR: 2·91, 95 % CI 1·57, 5·40, P=0·001). Our results suggest that these genetic variants contribute to obesity susceptibility in children and adolescents and reinforce the idea that the additive effect may be useful to elucidate the genetic component of obesity.

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Section: Discussionsupporting

confidence: 92%

Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents

et al. 2018

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“…Obesity pandemic is a much more common, demanding for vital attention, than other non-communicable diseases [24]. However, currently childhood obesity has become a major public health issue [25] [26]. Gravity of increased prevalence of childhood obesity could be demonstrated from the fact-this will be the first generation in which children would die before their parents in significant numbers [13] [27].…”

Section: Resultsmentioning

confidence: 99%

“…Obesity is a multifactorial condition with a strong lifestyle-allied influence. It is determined by environmental as well as genetic factors, triggering several other diseases [25] [28] [29]. Familial history has been identified as a chief risk factor for several chronic diseases of public health significance, including obesity.…”

Section: Discussionmentioning

confidence: 99%

Familial Background as a Hidden Cause for Obesity among College Going Girls

Mangla¹,

Dhamija²,

Gupta³

et al. 2019

JBM

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Background: Rapid changes in global economies and industrialization have resulted in switch from traditional diets and labor intensive lifestyle to consumption of modern calorie-rich diets loaded with fat and sugar contents, accompanied with sedentary lifestyle further leading to onset of numerous non-communicable, chronic disorders; obesity being one of them. This study aims at investigating risk posed by family history of obesity over the generations for inducing extreme overweight conditions among adolescent females of Delhi. Methods: Present work is a cross-sectional study conducted in Delhi (India) with sample size of 444 females aged between 18-22 years. Socio-demographic aspect along with lifestyle-related profile of participants was assessed using a self-administered proforma. Prior history of obesity among family members, if any, was noted as well, and anthropometric and physiologic measurements were recorded using well established customary techniques. Analysis was carried out in SPSS 20.0. Results: Participants holding a history for obesity in family were comparatively more obese than their counterparts. Positive family history for the same has been found possessing a notably closer association with elevated levels of adiposity determined by various physical and physiological variables. Conclusion: Family history of excessive fatness develops high risk of pathological manifestation for the same in upcoming generations that needs to be administered effectively-at individual or population level, and addressed efficiently by one's family or by the prevailing governmental provisions.

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“…Salienta-se que a distribuição genotípica do SNP rs9939609, tabela 2, encontram-se em equilíbrio de Hardy-Weingerg (p>0,05). Idade (anos) 12,0 (9,0-14,0) 12,0 (10,0-14,0) 12,0 (9,0-14,0) 0,184 TAE (meses) 4,0 (3,0-6,0) 4,0 (3,0-6,0) 4,0 (3,0-6,0) 0 É conhecido e amplamente relatado na literatura científica que a presença do alelo A no SNP rs9939609 do gene FTO, sobretudo do genótipo AA, está relacionada à elevação de parâmetros antropométricos (FIELD et al, 2007;BERENTZEN et al, 2008;YANG, et al, 2014;REUTER et al, 2016). Diante disso, um estudo realizado na Europa, por Frayling et al (2007), com uma amostra de 38.759 indivíduos encontrou uma frequência de 16% de indivíduos homozigotos A, sendo que este grupo alélico apresentou um risco 20% e 30% maior de apresentar (OHASHI et al, 2007).…”

Section: Resultsunclassified

“…Estudos observaram, ainda, que o alelo de risco A apresenta correlação positiva com aumento da CC em comparação com o alelo T e com o IMC (AL-ALTTAR et al, 2008;BO et al, 2010;YANG et al,. 2014) A influência do SNP rs9939609 na elevação dos parâmetros de adiposidade, incluindo crianças e adolescentes, já é consolidada na literatura (FIELD et al, 2007;BERENTZEN et al, 2008;YANG, et al, 2014;REUTER et al, 2016). Paralelo a isso, o aleitamento materno também conhecidamente garante benefícios à nutrição do lactente e, segundo Koletzko et al (2009)…”

Section: Resultsunclassified

Influência do tempo de aleitamento materno exclusivo no efeito do genótipo de risco do FTO rs9939609 em modelo recessivo

Gouveia

Matos

Neumann

et al. 2019

RJP

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O leite materno é considerado pela comunidade científica um alimento completo, pois atende integralmente às necessidades nutricionais, metabólicas e imunológicas do lactente até os seis meses de vida. No entanto, os efeitos positivos sobre a saúde do lactente não se restringem ao período neonatal, à medida que os conhecimentos epigenéticos vinculam intrinsecamente os futuros padrões antropométricos e bioquímicos com o tempo de aleitamento materno exclusivo. Somado a isso, a obesidade é uma doença crônica multifatorial e poligênica que assola a saúde mundialmente. Essa conjuntura é preocupante pelo seu caráter epidêmico e por vincular-se intrinsecamente a graves disfunções metabólicas como dislipidemia, diabetes e hipertensão arterial sistêmica. Sabe-se que a carga genética é contribuinte para a suscetibilidade de desenvolvimento da obesidade, então, os Polimorfismos de Nucleotídeo Único (SNP) no gene FTO (Fat mass obesity-associated) revelam-se concatenados a alterações nos parâmetros antropométricos e bioquímicos. Contudo, o estudo, de caráter transversal, intentou avaliar se a amamentação e seus benefícios influenciariam o efeito do genótipo de risco do gene FTO e suas repercussões nos parâmetros antropométricos e bioquímicos de escolares. Assim, observou-se que a amamentação exclusiva por tempo ≤3 meses influencia significativamente o efeito da genotipagem da variante rs9939609 no gene e se diferencia entre os sexos na manifestação dos parâmetros antropométricos.

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Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity

Abstract: There is an association between the AA genotype of rs9939609 polymorphism and BMI among schoolchildren. The association between overweight/obesity in schoolchildren with a family history of obesity was found mainly among students with the AA genotype.

Cited by 27 publications

References 23 publications

Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents

Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents

Familial Background as a Hidden Cause for Obesity among College Going Girls

Influência do tempo de aleitamento materno exclusivo no efeito do genótipo de risco do FTO rs9939609 em modelo recessivo

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