Association between PER3 length polymorphism and onco-hematological diseases and its influences on fatigue on awakening in patients

Abstract

Circadian clock gene PER3 and its length polymorphism may have a role in oncogenesis as clock genes act as key regulators of cell cycle and DNA repair pathways. The polymorphism may affect the condition of patients who show disrupted circadian rhythm due to tumor development. The aim was to assess the association between PER3 polymorphism and onco-hematological diseases, and analyze whether this variant has an impact on patient's functionality. We conducted a case-control study on 125 patients with onco-hematological diseases and 310 control patients. PER3 allelic variants were detected by using polymerase chain reaction. Sociodemographic data and information on patient's habits and functionality were obtained through questionnaire. Genotypes 4/5 + 5/5 showed an odd ratio (OR) = 1.39, with no statistical significance. However, those genotypes were associated with a two-fold increase in the risk of acute/chronic lymphoblastic/myeloblastic leukemia, taken all together. The occurrence of "changes in humor during last two months" was significantly associated with onco-hematological diseases. "Fatigue on awakening" and "self-reported snore" were associated with cases carrying the 4/5 or 5/5 genotypes. The results suggested that PER3 polymorphism may have a role in the risk of leukemia, and might be a possible marker for individual differences in susceptibility to sleep disruption. This work provides insights for the identification of individuals at high risk of cancer, and those who are more susceptible to circadian disruption, which may decrease the physiological defenses against the tumor. he circadian system regulates metabolism and energy homeostasis on a daily basis in order to maintain vital processes and prepare the organism to respond to predictable/daily environmental conditions [1] . Accordingly, most of the mammalian physiology is regulated at some points by the main circadian clock which is located at the hypothalamic suprachiasmatic nuclei (SCN). Circadian coordination is known to be T

A PER3 Polymorphism Interacts with Sleep Duration to Influence Transient Mood States in Women

“…We combined the PER3(4/5) and PER3(5/5) genotypes into one group due to the ubiquitous shortage of the homozygous 5-repeat allele and to isolate the effects of the 4 repeat allele. This is consistent with previous studies that have investigated this PER3 polymorphism [ 33 34 35 36 37 38 39 ]. Our cutoff score of 6 hours or less for short sleep duration was chosen since the neurobehavioral consequences of sleep restriction begin to be observed at 6 hours of sleep (or time in bed) [ 40 41 42 43 ].…”

Cigarette smoking, dietary habits and genetic polymorphisms inGSTT1,GSTM1andCYP1A1metabolic genes: A case-control study in oncohematological diseases

“…Dr. Rodolfo Rossi”. Demographic characteristics are listed in Table 1 , and were already published by our group in Cerliani et al[ 22 ]. Missing data for each variable were not included in the analysis, nor are detailed in the tables.…”