Association between periodontal flap surgery for periodontitis and vasculogenic erectile dysfunction in Koreans

Lee, Jae‐Hong; Choi, Jong-Moon; Kim, Sang-Hyun; Cho, Kyung Hyun; Kim, Young Taek; Choi, Seong‐Ho; Jung, Ui Won

doi:10.5051/jpis.2017.47.96

Cited by 5 publications

(8 citation statements)

References 32 publications

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“…A total of 74 percent ( n = 38) of all included studies applied a cohort design . In addition, seven studies reported a case–control design, five studies reported a cross‐sectional, and one study a case‐crossover design . Two studies reported a cohort design, but because the exposure and outcome variables were collected over the same time period and no time‐related reference could be made, these studies were classified as cross‐sectional designs.…”

Section: Resultsmentioning

confidence: 99%

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Methodological approaches for investigating links between dental and chronic diseases with claims data: A scoping study

Blaschke

Seitz

Schubert

et al. 2019

J Public Health Dent

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Objectives: The purpose of this study was to provide an overview of methodological approaches to assess the relationship between dental diseases and other noncommunicable diseases on the basis of claims data. Methods: Based on the methodological framework of Arksey and O'Malley, a scoping study was conducted. By searching electronic databases (PubMed, Web of Science, and LILACS), appropriate articles were identified. After extracting relevant information and entering it into a data-charting form, the study characteristics and the methodological approaches were summarized descriptively.Results: Fifty-one articles were identified for inclusion in the analysis. Most of the selected studies (78 percent) originated from Taiwan and employed a cohort design. The majority of studies considered dental diseases, particularly periodontal disease (PD) measures, but no common standard was identified for the definition of PD. Unmeasured confounding, misclassification, and surveillance bias were reported to be the main limitations of the claims data analyses. Conclusions: Claims data provide a very useful information source to further delineate the relationship between PDs and other noncommunicable diseases. If diagnostic codes are available, they seem to be the most suitable tool to assess PD in claims-based studies. In databases that do not contain dental diagnostic codes, e.g., databases in Germany and the United States, the identification of PD is a particular challenge. The inclusion of dental diagnostic codes in all claims databases is strongly recommended. Due to the public health relevance of PD, there is a need for more comprehensive documentation of dental parameters within claims data.

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Section: Resultsmentioning

confidence: 99%

“…Five studies could not be assigned to one of the areas listed above as they were based on a cross‐sectional design …”

Section: Resultsmentioning

confidence: 99%

Methodological approaches for investigating links between dental and chronic diseases with claims data: A scoping study

Blaschke

Seitz

Schubert

et al. 2019

J Public Health Dent

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“…Also, the evidence about the role of ED and periodontitis is scarce in European population, because the majority of the studies have been performed on Asian population. [13][14][15][44][45][46][47] As potential limitations of this study, the use of medical records as source for the assessed outcomes could have led to a loss of information. This information bias was managed by contacting each subject by phone as possible and ensure that the data in medical records were precise.…”

Section: Discussionmentioning

confidence: 99%

Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

Mesa

Arrabal-Polo

Magán‐Fernández

et al. 2022

Journal of Periodontology

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Background: Periodontitis and erectile dysfunction (ED) have been linked with cardiovascular disease. The association of periodontitis and ED with the occurrence of major adverse cardiovascular events has not been previously assessed.The aim of this study was to determine if the presence of periodontitis and ED has any effect on the incidence of major adverse cardiovascular events.Methods: Male patients that attended the Urology service were enrolled in a prospective study. Erectile dysfunction was diagnosed according to the International Index of Erectile Function. Sociodemographic data and periodontal clinical parameters were gathered (pocket probing depth, clinical attachment loss, bleeding on probing (BoP), plaque index and number of teeth) at baseline. Major adverse cardiovascular events occurred both before and during the follow-up time were registered. Bivariate analyses, as well as a multivariate analysis were performed, adjusting for potential confounders. Results: A total of 158 patients were included, with a mean follow-up of 4.2 years.A greater number of major adverse cardiovascular events occurred in the group that presented periodontitis and ED (P = 0.038). After adjusting by age and previous cardiovascular disease in the multivariate analysis, the annual major adverse cardiovascular event rate was estimated to be 3.7 times higher in the same group (P = 0.049). Other periodontal clinical variables together with ED supported these results and were close to statistical significance. Conclusions: Patients with periodontitis and ED, adjusted by age and a cardiovascular disease, showed 3.7 times more risk of suffering major adverse cardiovascular events after mean follow-up of 4.2 years.

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“…The only exception was the study reported by Sharma, which did not show any statistical significance in the association (Sharma et al, 2011). Two studies reported an intervention with treatment (Eltas et al, 2013; Lee et al, 2017). The reasons why studies were not included in the current are available in Table 3.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

et al. 2021

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The objective of this study is to investigate the association between periodontitis (PD) and erectile dysfunction (ED). A systematic review and meta-analysis on data was extracted and conducted according to PRISMA. Relevant articles were selected from a literature search using MEDLINE, EMBASE, Scopus, Web of Science and CENTRAL from inception until August 2, 2020. Both randomized and nonrandomized controlled studies were included. Case reports, case series, nonsystematic reviews and trials published as abstract were excluded. Odds ratios (ORs) and corresponding 95% conﬁdence intervals (CIs) were used to estimate the association between PD and the risk of ED. The meta-analysis was conducted with RevMan 5.3. Methodological quality assessment was carried out using the Newcastle-Ottawa Quality Assessment Scale and the quality of evidence was assessed using the GRADE approach. Six articles (215008 subjects) were included for analysis. Of the participants, 38,675 cases were compared to 1,76,333 healthy controls. Based on the random effects model, periodontitis was associated with an increased risk of ED (OR = 2.56, 95% CI: 1.70–3.85) as compared with the non-periodontitis individuals. The findings were statistically significant with a p < .0001. The statistical heterogeneity was high across all studies ( I2 = 98%, p < .00001). Estimates of total effects were generally consistent with the sensitivity and subgroup analyses. Within the limits of the available evidence, our review and meta-analysis showed that a significant association exists between the PD and ED. The results should be interpreted with caution due to high degree of inconsistency across all the studies.

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Association between periodontal flap surgery for periodontitis and vasculogenic erectile dysfunction in Koreans

Cited by 5 publications

References 32 publications

Methodological approaches for investigating links between dental and chronic diseases with claims data: A scoping study

Methodological approaches for investigating links between dental and chronic diseases with claims data: A scoping study

Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

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