Association Between Plasma Concentration of Klotho Protein, Osteocalcin, Leptin, Adiponectin, and Bone Mineral Density in Patients with Chronic Kidney Disease

Marchelek-Myśliwiec, Małgorzata; Wiśniewska, Magda; Nowosiad-Magda, Monika; Safranow, Krzysztof; Kwiatkowska, Ewa; Banach, Bolesław; Dołęgowska, Barbara; Dolegowska, Katarzyna; Stępniewska, Joanna; Domański, Leszek; Pawlik, Andrzej; Ciechanowski, Kazimierz

doi:10.1055/a-0752-4615

Cited by 16 publications

(14 citation statements)

References 39 publications

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“…Metabolites 2020, 10, 98 2 of 11 lipid profile and serum adipokine levels [3][4][5]. Changes in adipokine levels have been discussed in the context of CKD progression and the risk of comorbidities [6][7][8][9]. Leptin is one of the hormones secreted by adipose tissue and has been recognized as a signaling molecule that regulates energy homeostasis [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…This protein also plays an important role in immune regulation and inflammation, both closely associated with oxidative stress and endothelial dysfunction, which may affect the risk of cardiovascular disorders [12][13][14]. Previous studies showed increased concentrations of leptin in the serum of patients with CKD [7,15]; however, the mechanism of this change is not well elucidated. CKD is also associated with significant lipid disorders.…”

Section: Introductionmentioning

confidence: 99%

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Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile

et al. 2020

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Chronic kidney disease (CKD) is associated with an increased level of leptin and an abnormal fatty acid (FA) profile in the serum. However, there are no data on the associations between them, and the reason for increased serum levels in patients with CKD is not well elucidated. Recently, we found that a CKD-related abnormal FA profile caused significant changes in the expression of genes involved in lipid metabolism in hepatocytes. The aim of this study was to examine whether leptin gene expression in subcutaneous adipose tissue (SAT) of patients with CKD may contribute to increased serum levels of this adipokine and whether the abnormal serum FA profile observed in CKD patients has an impact on leptin gene expression in adipocytes. The FA profile was measured in serum samples from patients with CKD and controls by GC-MS. The relative mRNA levels of leptin were measured in SAT by Real-Time PCR. Moreover, the effect of the CKD-related abnormal FA profile on leptin gene expression was studied in in vitro cultured 3T3-L1 adipocytes. Patients with CKD had higher concentrations of serum leptin than controls and higher expression level of the leptin gene in SAT. They also had increased serum monounsaturated FAs and decreased polyunsaturated FAs. The incubation of adipocytes with FAs isolated from CKD patients resulted in an increase of the levels of leptin mRNA. Increased leptin gene expression in SAT may contribute to elevated concentrations of these adipokine in patients with CKD. CKD-related alterations of the FA profile may contribute to elevated serum leptin concentrations in patients with CKD by increasing the gene expression of this adipokine in SAT.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile

et al. 2020

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“…Potential mechanisms of the increased cardiovascular risk in CKD also include changes in the lipid profile and serum adipokine levels. Over the past few years, changes in adipokine levels in the context of CKD progression and the risk of comorbidities have been investigated by many researchers [ 9 , 13 , 14 , 15 , 27 , 76 , 82 , 83 ].…”

Section: Effects Of Increased Leptin Concentrations On the Risk Of Cardiovascular Disease In Patients With Ckdmentioning

confidence: 99%

“…One of the most investigated adipokines is leptin. Circulating leptin levels are elevated even in the early stages of CKD [ 7 ], and leptin levels increase with disease progression [ 15 , 16 ]. A number of studies have shown that leptin is involved in both CKD progression and CKD complications [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Causes and Potential Injurious Effects of Elevated Serum Leptin Levels in Chronic Kidney Disease Patients

Korczyńska

Czumaj

Chmielewski

et al. 2021

IJMS

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Leptin is an adipokine that regulates appetite and body mass and has many other pleiotropic functions, including regulating kidney function. Increased evidence shows that chronic kidney disease (CKD) is associated with hyperleptinemia, but the reasons for this phenomenon are not fully understood. In this review, we focused on potential causes of hyperleptinemia in patients with CKD and the effects of elevated serum leptin levels on patient kidney function and cardiovascular risk. The available data indicate that the increased concentration of leptin in the blood of CKD patients may result from both decreased leptin elimination from the circulation by the kidneys (due to renal dysfunction) and increased leptin production by the adipose tissue. The overproduction of leptin by the adipose tissue could result from: (a) hyperinsulinemia; (b) chronic inflammation; and (c) significant lipid disturbances in CKD patients. Elevated leptin in CKD patients may further deteriorate kidney function and lead to increased cardiovascular risk.

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“…Leptin is typically elevated in patients with renal failure, whereas deterioration of the renal function leads to homoeostatic disturbances in bone and adipose tissue [16,17]. Although leptin has important roles in bone remodeling, its effect on bone density of patients on hemodialysis is unclear.…”

Section: Introductionmentioning

confidence: 99%

Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients

Wang

Lai

Lin

et al. 2020

International Journal of Endocrinology

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Background. Leptin acts through the adipose-bone axis to regulate bone mineral density (BMD). This study evaluated the relationship between BMD and serum leptin levels in patients on hemodialysis. Methods. In this cross-sectional study including 98 hemodialysis patients, BMD was measured using dual energy X-ray absorptiometry of the lumbar vertebrae (L2–L4), and serum leptin levels were determined using an enzyme immunoassay. Results. There were 25 (25.5%), 13 (13.3%), and 60 (61.2%) patients with osteopenia, osteoporosis, and normal BMD, respectively. Advanced age P=0.017; decreased body mass index (BMI, P<0.001); body height P<0.001; prehemodialysis body weight (BW, P<0.001); post-hemodialysis BW P<0.001; waist circumference P<0.001; and triglyceride P=0.015, albumin P=0.004, and leptin levels P=0.017 were associated with lower lumbar T scores, whereas increased urea reduction rate (URR, P=0.004) and fractional clearance index for urea (Kt/V, P=0.004) were associated with lower lumbar T scores. The multivariable forward stepwise linear regression analysis with adjustment for sex; age; body height; prehemodialysis BW; BMI; waist circumference; logarithmically transformed triglycerides (log-triglycerides), albumin, creatinine, and leptin (log-leptin) levels; URR; and Kt/V indicated that high serum level of log-leptin (R2 change = 0.184; P<0.001), increased prehemodialysis BW (R2 change = 0.325; P=0.008), male sex (R2 change = 0.048; P=0.001), young age (R2 change = 0.044; P=0.012), and increased serum albumin level (R2 change = 0.017; P=0.044) were significantly and independently associated with lumbar BMD. Conclusions. Advanced age and female sex were associated with poor BMD, whereas increased BW, serum albumin, and leptin levels were positively associated with BMD in patients on hemodialysis.

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Association Between Plasma Concentration of Klotho Protein, Osteocalcin, Leptin, Adiponectin, and Bone Mineral Density in Patients with Chronic Kidney Disease

Cited by 16 publications

References 39 publications

Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile

Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile

The Causes and Potential Injurious Effects of Elevated Serum Leptin Levels in Chronic Kidney Disease Patients

Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients

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