Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

Chen, Ying; Fan, Xue-yun; Jin, Yulan; Yao, Sanqiao; Xiang, Yun; Zhong, Hua; Shen, Fuhai

doi:10.7314/apjcp.2014.15.20.8775

Cited by 11 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is in agreement with that of Paradowska-Gorycka et al (2010), which proposes that the IL-17F His161Arg substitution may directly regulate the IL-17F expression. However, our findings were not in concordance with the reported results of Chen et al (2014) which implied that IL-17F (þ7488A/G) genotype was statistically associated with a decreased risk of silicosis when compared with A/A genotype. These opposite results might be due to the ethnicity as well as different functions of IL-17 in different human diseases (Chen et al, 2014).…”

Section: Discussioncontrasting

confidence: 99%

“…However, our findings were not in concordance with the reported results of Chen et al (2014) which implied that IL-17F (þ7488A/G) genotype was statistically associated with a decreased risk of silicosis when compared with A/A genotype. These opposite results might be due to the ethnicity as well as different functions of IL-17 in different human diseases (Chen et al, 2014). In silicosis, the mechanism by which IL-17A and IL-17F gene polymorphisms insert their actions is still unexplained.…”

Section: Discussioncontrasting

confidence: 99%

“…IL-17A rs4711998 (À832A/G) polymorphisms were evaluated using forward primer: 5 0 -TTACACTC-CAGCCATTGAGTTG-3 0 and reverse primer: 5 0 -TGAAAATGGGGATAGAGACTGG-3 0 under a PCR profile of 35 cycles (30 s at 95 C, 30 s at 58 C, and 30 s at 72 C) (Chen et al, 2014). The amplified PCR products were digested at 65 C for 30 min using Taq I. IL-17F rs763780 (þ7488A/G) polymorphisms were analyzed using forward primer: 5 0 -ACCAAGGCTGCT CTGTTTCT-3 0 and reverse primer: 5 0 -GGTAAG-GAGTGGCATTTCTA-3 0 under a PCR profile of 38 cycles (30 s at 95 C, 45 s at 60 C, and 45 s at 72 C) (Chen et al, 2014). Electrophoretic analysis of PCR products was carried out on 3% agarose gel stained with CinnaGen DNA safe Stain (CinnaGen Co., Tehran, Iran), and the presence or absence of fragments was monitored by UV transilluminator.…”

Section: Methodsmentioning

confidence: 99%

“…Ethnicity mainly influences the association between single nucleotide polymorphisms (SNPs) in a cytokine gene and human diseases (Gonzalez-Hormazabal et al, 2014). Chen et al (2014) studied SNPs at IL-17A (À832A/G) and IL-17F (þ7488A/G) on samples obtained from gold mine or steel enterprise (Chen et al, 2014). Chen et al (2014) showed that IL-17F (þ7488A/G) polymorphism may contribute to the risk of silicosis but failed to show association between IL-17A (À832A/ G) polymorphism and silicosis (Chen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association between SNPs at IL-17A and IL-17F and susceptibility to accelerated silicosis

et al. 2017

View full text Add to dashboard Cite

The association between single nucleotide polymorphisms (SNPs) in the interleukin (IL)-17 gene and silicosis has been evaluated in different populations. The aim of the present study was to analyze the association between SNPs at IL-17A (-832A/G) and IL-17F (+7488A/G) and susceptibility to accelerated silicosis in the Iranian Kurdish population. We studied 48 patients with accelerated silicosis and 62 controls. Genomic DNA was isolated using the "salting out" method. PCR-RFLP was performed for all SNPs typing. The frequencies of A/A, A/G, and G/G genotypes at IL-17A (-832A/G) were 4 (8.33%), 23 (47.92%), and 21 (43.75%) in patients and 5 (8.06%), 35 (56.45%), and 22 (35.48%) in controls, respectively. The frequencies of A and G alleles at IL-17 (-832A/G) were 31 (32.29%) and 65 (67.71%) in patients, and 45 (36.29%) and 79 (63.71%) in the controls, respectively. The frequencies of A/A, A/G, and G/G genotypes at IL-17F (+7488A/G) were 1 (2.08%), 47 (97.92%), and 0 (0%) in patients, and 11 (17.74%), 51 (82.26%), and 0 (0%) in the controls, respectively. The frequencies of A and G alleles at IL-17F (+7488A/G) were 49 (51.04%) and 47 (48.96%) in patients, and 73 (58.87%) and 51 (41.13%) in the controls, respectively. IL-17F (+7488A/G) genotype was more frequent among the cases compared with controls (97.92% vs. 82.26%). The frequency of the IL-17F (+7488A/G) genotype was significantly greater in patients with accelerated silicosis (odds ratio = 10.13 95%; confidence interval = 1.2-81.5; p = 0.008). The IL-17F (+7488A/G) genotype revealed a significantly increased risk of accelerated silicosis ( p < 0.05). The IL-17F (+7488 G) allele was associated with an increased risk of accelerated silicosis, but in the case of the IL-17A (-832A/G) polymorphism, a significant association was not observed.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between SNPs at IL-17A and IL-17F and susceptibility to accelerated silicosis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…On the other hand, it is well known that interstitial pneumonia (IP) and chronic obstructive pulmonary disease (COPD) cause inflammation and affect cytokine production [45,46]. Cytokine gene polymorphisms in IP [47] and COPD [48] and their association with lung cancer were reported [7,8]. In this study, although we did not directly measure cytokine production in NSCLC patients, we anticipate that IFN-γ and IL-10 production will be affected by polymorphisms.…”

Section: Tnfα G/g + Ifnγmentioning

confidence: 77%

Association of TNFα−308, IFNγ+874, and IL10−1082 gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana

Peddireddy

Badabagni

Sulthana³

et al. 2016

Int J Clin Oncol

View full text Add to dashboard Cite

show abstract

Occupational exposure to crystalline silica and peripheral biomarkers: An update

Peruzzi

Brucker

Bubols

et al. 2021

J of Applied Toxicology

View full text Add to dashboard Cite

Peripheral biomarkers are important tools for detecting occupational exposures to prevent the onset and/or progression of diseases. Studies that reveal early peripheral biomarkers are highly important to preserve the health of workers and can potentially contribute to diagnosing and/or prognosing occupational pathologies. Exposure to crystalline silica is a problem in several workplaces because it increases the risk of chronic obstructive pulmonary disease (COPD), tuberculosis, cancer, and pulmonary fibrosis, clinically defined as silicosis. Silicosis is diagnosed by chest radiography and/or lung tomography in advanced stages when there is a severe loss of lung function. Peripheral biomarkers can help in diagnosing early changes prior to silicosis and represent a highly important technical‐scientific advance that is minimally invasive. This review aimed to investigate the biomarkers studied for evaluating occupational exposure to crystalline silica and to understand the recent advances in this area. Potential oxidative, inflammatory, and immunological biomarkers were reviewed, as well as routine biomarkers such as biochemical parameters. It was found that biomarkers of effect such as serum CC16 and l‐selectin levels could represent promising alternatives. Additionally, studies have shown that neopterin levels in urine and serum can be used to monitor worker exposure. However, further studies are needed that include a greater number of participants, different times of exposure to crystalline silica, and a combination of silicosis patients and healthy volunteers. Evaluating the concentration of crystalline silica in occupational environments, its impact on biomarkers of effect, and alterations in lung function could contribute to revealing early health alterations in workers in a more robust manner.

show abstract

Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

Cited by 11 publications

References 21 publications

Association between SNPs at IL-17A and IL-17F and susceptibility to accelerated silicosis

Association between SNPs at IL-17A and IL-17F and susceptibility to accelerated silicosis

Association of TNFα−308, IFNγ+874, and IL10−1082 gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana

Occupational exposure to crystalline silica and peripheral biomarkers: An update

Contact Info

Product

Resources

About