Association Between Serum Uric Acid Levels and Traditional Cardiovascular Risk Factors in Xiamen Residents of China: A Real-World Study

Abstract

BackgroundSerum uric acid (SUA) levels was associated with cardiovascular diseases and cardiovascular events. However, the relationship between SUA levels and traditional cardiovascular risk factors has not been well-established among Xiamen residents. Our study aimed to estimate the relationship between SUA levels and cardiovascular risk factors among Xiamen residents using real-world data.MethodsParticipants were enrolled from eight community health service centers in Xiamen, China. Participants were divided into four groups according to quartiles of the SUA levels. The history of diseases, the use of medications and the levels of laboratory parameters were collected. The China-PAR equation was used to evaluate the 10-year atherosclerotic cardiovascular disease (ASCVD) risk.ResultsA total of 1,322 participants were enrolled. About 568 (43.0%) were men and 754 (57.0%) were women. The prevalences of hypertension, elderly, current smokers, and obesity were higher in the quartile 4 (Q4) group than the quartile 1 (Q1) group (all p < 0.001). Multivariable logistic regression analysis showed the OR for hypertension was 2.671 (95% CI 1.777–4.015, p < 0.001) in the Q4 group compared with that in the Q1 group. Further logistic regression showed the OR for hypertension was 3.254 (95% CI 1.756–6.031, p < 0.001) in men and 2.314 (95% CI 1.354–3.955, p = 0.002) in women in the Q4 group compared with that in the Q1 group, respectively. In addition, the percentage of participants with low 10-year ASCVD risk calculated by China-PAR was higher in the Q1 group than that in the Q4 group (55.86 vs. 31.82%, p < 0.001). The percentage of participants with high 10-year ASCVD risk was lower in the Q1 group compared with the Q4 group (15.32 vs. 25.45%, p < 0.001). Multiple linear logistic regression showed the 10-year China-PAR ASCVD risk scores was positively correlated with SUA after adjusting for various factors (β = 0.135, p = 0.001).ConclusionSerum uric acid was associated with several cardiovascular risk factors in Xiamen residents. The percentage of high 10-year ASDVD risk was higher in participants with hyperuricemia. Participants with hyperuricemia may experience cardiovascular benefit from uric acid-lowering therapy.

Clinical outcomes of obstructive sleep apnea in patients with acute coronary syndrome in relation to hyperuricemia status

“…Serum uric acid levels were strongly associated with cardiovascular events in patients at high risk of heart disease and in women (Feig et al, 2008). A study including the elderly showed that high uric acid levels were associated with all‐cause and cardiovascular mortality (Wu et al, 2015; Zhang et al, 2022). However, previous studies were mainly retrospective or cross‐sectional studies, and the analysis mainly focused on the correlation between OSA and uric acid level, the prognosis of OSA and ACS, and the relationship and risk between uric acid and coronary heart disease, and failed to confirm the effect of OSA on prognosis in patients with ACS complicated with hyperuricemia.…”

The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor

“…CAD has a variety of risk factors, and often reflected in clinical manifestations such as frequent episodes of angina pectoris, intractable heart failure, and malignant arrhythmias [ 35 ]. Elevated uric acid levels are associated with traditional CAD risk factors, including hypertension, diabetes mellitus, dyslipidemia, and obesity [ [9] , [10] , [11] ]. Previous prospective studies have shown a concomitant increase in the risk of developing hypertension with increased circulating uric acid concentrations [ 43 ].…”

“…Although some studies question the independent risk role of uric acid and more studies suggest that hyperuricemia has a negative impact on the onset, progression and prognosis of CAD [ [5] , [6] , [7] , [8] ]. There is also evidence that hyperuricemia is inextricably linked to traditional risk factors for CAD, which may have jointly contributed to the onset and development of CAD [ [9] , [10] , [11] ].…”