Association Between Single-Nucleotide Polymorphisms in <i>Interleukin-12A</i> and Risk of Chronic Obstructive Pulmonary Disease

Wang, Enyin; Liang, Weibo; Zhang, Lin

doi:10.1089/dna.2012.1719

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…In opposition to our results, the C allele was associated with higher risk of a wide range of diseases of immune dysregulation, including psoriasis, ankylosing spondylitis , nasopharyngeal , cervical and oesophageal cancers . However, no association was found between this variant and Chronic obstructive pulmonary disease (COPD) , pulmonary tuberculosis , Type I Diabetes, Acute coronary syndrome (ACS), pre‐eclampsia , psoriasis and IBD .…”

Section: Discussioncontrasting

confidence: 99%

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

et al. 2013

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Brucellosis remains a major zoonosis worldwide. Brucella antigens induce the production of T-helper 1 (Th1) cytokines such as interleukin-12 (IL-12) in humans. We aimed to investigate the association of two single nucleotide polymorphisms (SNPs) in the gene encoding the IL-12p40 cytokine (IL-12B) with brucellosis and to examine the functionality of these SNPs through measuring serum levels of IL-12p40. We genotyped IL-12B gene rs3212227, A>C; rs6887695 G>C polymorphisms in a case-control study on a total of 281 subjects including 153 patients with active brucellosis and 128 healthy controls, using RFLP and serum IL-12p40 levels, were assessed by ELISA. The rs3212227 minor allele (C) and homozygote genotype (CC) were more frequent in controls compared with patients with brucellosis (P = 0.006, OR = 0.608, 95%CI = 0.429-0.861 for the C allele; P = 0.024, OR = 0.443, 95% CI: 0.218-0.900 for the CC genotype). Comparison of IL-12B genotypes and serum levels of the IL-12p40 revealed that rs3212227 AA genotype, with higher frequency in patients than in controls, was associated with increased levels of the cytokine (P = 0.0001). Furthermore, the distribution of haplotype and genotype combinations in our study suggested that rs3212227C/rs6887695C haplotype or CC/GC or CC/CC genotype combinations may protect controls against Brucella infection by contributing to a functional downregulation of the serum IL-12p40 production in vivo, as shown by ELISA (P < 0.05). Overall, our study demonstrated that rs3212227 A variant was associated with higher levels of serum IL-12p40 and could possibly contribute to an inherited predisposition to brucellosis.

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Section: Discussioncontrasting

confidence: 99%

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

et al. 2013

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“…On the other hand, Sima and colleagues found that variant G allele carriers of IL12A rs2243115 were at higher risk of brain tumors compared with those carrying the wild-type T allele (34). Almost at the same time, Wang and colleagues provided evidence that the variant G allele at IL12A rs2243115 also contributes to higher risk of chronic obstructive pulmonary disease (35). To our knowledge, there is no other report examining the contribution of IL12A genotypes to oral cancer.…”

Section: Discussionmentioning

confidence: 99%

The Contribution of Interleukin-12A Genotypes to Oral Cancer Risk in Taiwanese

Shih

Hsu

et al. 2020

Anticancer Res

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Background/Aim: Oral cancer incidence is highest worldwide in Taiwan, and practical markers for personalized therapeutic strategies such as immunotherapies, is lacking. Interleukin-12 (IL12) is a cytokine that is reported to exhibit potent tumoricidal effects, however, its genotypic contribution to oral cancer is still largely unknown. We aimed to examine whether IL12A rs568408 and rs2243115 genotypes are associated with oral cancer risk in Taiwan. Materials and Methods: Genotypic characteristics of IL12A were determined among 958 oral cancer cases and age-and gender-matched individuals via typical polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The variant genotypes of IL12A rs568408 and rs2243115 were not found to be significantly associated with elevated oral cancer risk (all p>0.05). Moreover, there was no interaction between IL12A genotypes and personal smoking, alcohol drinking and betel quid chewing behaviors (all p>0.05). Conclusion: IL12A rs568408 and rs2243115 genotypes may not serve as good predictors for oral cancer risk.

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“…[ 41 ] Additionally, Wang et al found that the frequencies of GT and GT+GG of IL-12A rs2243115 were significantly different from TT in chronic obstructive pulmonary disease (COPD), which further suggested that IL-12A rs2243115 polymorphism may contribute to genetic susceptibility to COPD. [ 42 ] Moreover, other studies indicated that the SNPs in IL-12A rs568404 might contribute to the risk of asthma and Graves’ disease in Chinese population; the TT genotype of IL-12A rs568408 was related to significantly decreased late-onset AD risk. [ 26 , 43 , 44 ] Since IL-12A was a subunit of IL-35 and recently IL-35 polymorphisms were explored to be related to the risk of CHD, [ 24 , 25 ] we aimed to explore the IL-35 polymorphisms on cognitive function in CHD patients.…”

Section: Discussionmentioning

confidence: 99%

IL-35 polymorphisms and cognitive decline did not show any association in patients with coronary heart disease over a 2-year period

Shi¹,

Zhang²,

Xue³

et al. 2020

Medicine

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Association Between Single-Nucleotide Polymorphisms in Interleukin-12A and Risk of Chronic Obstructive Pulmonary Disease

Cited by 9 publications

References 27 publications

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

The Contribution of Interleukin-12A Genotypes to Oral Cancer Risk in Taiwanese

IL-35 polymorphisms and cognitive decline did not show any association in patients with coronary heart disease over a 2-year period

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