Association between surrogate indicators of insulin resistance and risk of type 2 diabetes combined with hypertension among Chinese adults: two independent cohort studies

Dong, Jing; Liu, Yuhong; Lu, Ya‐Ke; Hu, Li‐Kun; Chen, Ning; Ma, Linlin; Chu, Xi; Yan, Yuxiang

doi:10.1186/s12986-022-00720-1

Cited by 9 publications

(4 citation statements)

References 41 publications

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“…Our mediation analyses showed TyG index playing a key role in the association of CVAI with HTN-DM comorbidity. Similar to our results, a study by Dong et al also reported TyG index mediating the association between BMI/WC and HTN-DM comorbidity (30). In addition, consistent with our findings for HTN or DM, recent studies found that the BMI-HTN or BMI-DM association was medicated by TyG index (31,32).…”

Section: Discussionsupporting

confidence: 93%

Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people

et al. 2023

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BackgroundChinese visceral adiposity index (CVAI) is a reliable indicator of visceral obesity, but little is known about the association of CVAI with comorbidity of hypertension (HTN) and diabetes mellitus (DM). This study aimed to explore the associations of CVAI with HTN-DM comorbidity, HTN or DM, HTN, and DM in elderly people and evaluate the mediating role of insulin resistance in the associations.MethodsA total of 3,316 Chinese participants aged ≥60 years were included in this cross-sectional study. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were applied to explore the dose–response associations. Mediation analyses were used to assess the mediating effect of triglyceride-glucose (TyG) index in the associations.ResultsThe prevalence rate of HTN-DM comorbidity, HTN or DM, HTN, and DM was 13.78%, 72.26%, 67.16%, and 18.88%, respectively. Linear associations between CVAI and HTN-DM comorbidity, HTN or DM, HTN, and DM were found, and ORs (95%CIs) were 1.45 (1.30–1.61), 1.39 (1.28–1.52), 1.36 (1.25–1.48), and 1.28 (1.16–1.41) for per SD increase in CVAI. Compared with quartile 1 of CVAI, the risk of HTN-DM comorbidity, HTN or DM, HTN, and DM increased 190%, 125%, 112%, and 96% for quartile 4. In addition, we found TyG index playing a key role in the associations of CVAI with HTN-DM comorbidity, HTN or DM, and DM.ConclusionCVAI is linearly and positively correlated with HTN-DM comorbidity, HTN or DM, HTN, and DM. The potential mechanism is insulin resistance largely mediating the associations.

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Section: Discussionsupporting

confidence: 93%

Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people

et al. 2023

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“…Ultimately, we included a total of 22 studies involving 668,486 participants, including 12 cross-sectional studies (28-39) and 10 cohort studies (40)(41)(42)(43)(44)(45)(46)(47)(48)(49). The participants were mainly from the general population in urban or rural areas, and a few studies mentioned special occupational groups.…”

Section: Study Characteristics and Quality Evaluationmentioning

confidence: 99%

Association between the risk of hypertension and triglyceride glucose index in Chinese regions: a systematic review and dose-response meta-analysis of a regional update

Xu,

Jin,

Shen

et al. 2023

Front. Cardiovasc. Med.

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BackgroundTriglyceride-glucose (TyG) index has been reported to be associated with various cardiovascular diseases in recent years. However, the conclusive association between the TyG index and hypertension was not established in the last meta-analysis. Furthermore, it remains unclear whether a linear relationship exists between these two variables.MethodsWe conducted a comprehensive search of the CNKI, VIP, WanFang Data, CBM, PubMed, EMbase, Web of Science, and The Cochrane Library databases up until May 10, 2023, to identify relevant studies conducted in China. We used Stata version 17.0 and Rstudio version 4.2.1 to analyze the data and assess the association between the TyG index and the risk of hypertension, as well as the dose-response relationship between these two variables. We will select either a random-effects model or a fixed-effects model based on the results of the heterogeneity tests and report 95% confidence intervals accordingly.ResultsIn the end, our analysis encompassed 22 studies involving a total of 668,486 participants, comprising 12 cross-sectional studies and 10 cohort studies. Meta-analysis results showed: Analysis of data from China revealed that an elevated TyG index was associated with a higher risk of developing hypertension, as indicated by an OR/HR of 1.36 [95%CI (1.28–1.45) I2 = 69.0% P < 0.001]. Through meta-regression analysis of multiple covariates, we found that study type, study region, sample size, database source, and study quality score, the above five variables were able to explain 63.0% of the total heterogeneity. The results of the dose-response Meta-analysis showed: The TyG index has a linear relationship with the risk of developing hypertension, as indicated by non-significant coefficients of higher-order terms in the nonlinear model (P > 0.05). The linear trend analysis showed that for every one-unit increase in the TyG index, the risk of developing hypertension increased by 1.5 times [1.532 95%CI (1.294, 1.813) P < 0.001]. However, this result is influenced by the number of studies included in the dose-response analysis and requires further corroboration.ConclusionIn the Chinese region, there was an independent association between TyG index and the risk of developing hypertension, with a linear trend. However, the results of the linear trend need to be corrected by the more number of related studies.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023425836.

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“…The study by Bala et al also showed that although there is a positive and strong relationship between the TyG-BMI index and hypertension, it is not superior to BMI and TyG index and TyG-WC [13]. In addition, several cross-sectional studies have introduced the TyG-BMI index as an accurate surrogate for IR to predict the risk of hypertension [13,15,27,28]. In general, the results of similar studies indicate a strong relationship between high the TyG-BMI and risk of hypertension, but the accuracy and power of prediction of TyG-BMI index for the early diagnosis of hypertension require more studies in different populations.…”

Section: Discussionmentioning

confidence: 99%

“…According to the limitation of IR measurement, its alternative indicators are usually used. One of the most complete surrogate indices of IR is the glucose-triglyceride body mass index (TyG-BMI), which is a combination of triglyceride, glucose, and BMI [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Triglyceride glucose-body mass index and hypertension risk in iranian adults: a population-based study

et al. 2023

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Background Insulin resistance (IR) and obesity are risk factors for hypertension; triglyceride-glucose (TyG) is known as a surrogate for IR. The present study investigated the association between the triglyceride-glucose body mass index (TyG-BMI) index and the risk of hypertension in Iranian adults. Methods This study was conducted on a sample of 8,610 participants from the baseline phase of the Ravansar non- communicable diseases (RaNCD) in Iran. A logistic regression model was used to evaluate the relationship between TyG-BMI and hypertension. Receiver operating characteristic (ROC) curve analysis was conducted to estimate the predictive power of TyG-BMI for hypertension. Results A total of 4176 men and 4434 women with an average age of 46.74 years were examined. The anthropometric indices were significantly higher in hypertensive than normotensive subjects (P < 0.001). The level of physical activity was significantly higher in the bottom quartiles (P < 0.001). The odds of hypertension in the highest quartile and 3.10 (95% CI: 2.28, 4.16) times significantly higher than the bottom quartile of the TyG-BMI index. The discriminating ability of TyG-BMI to predict blood pressure was 61% (AUC: 0.61; 95% CI: 0.57, 0.63), and higher than BMI and TyG. Conclusion The TyG-BMI index is associated with an increase in the odds of hypertension. Therefore, the TyG-BMI index can be a new clinical index for early diagnosis of hypertension. Lifestyle modifications such as weight control through physical activity and a healthy diet can help improve IR and prevent hypertension.

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Association between surrogate indicators of insulin resistance and risk of type 2 diabetes combined with hypertension among Chinese adults: two independent cohort studies

Cited by 9 publications

References 41 publications

Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people

Dose–response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people

Association between the risk of hypertension and triglyceride glucose index in Chinese regions: a systematic review and dose-response meta-analysis of a regional update

Triglyceride glucose-body mass index and hypertension risk in iranian adults: a population-based study

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