Association Between the Early Serum Lipid Metabolism Profile and Delayed Neurocognitive Recovery After Cardiopulmonary Bypass in Cardiac Surgical Patients: a Pilot Study

Han, Jingjing; Huang, He; Li, Zheng; Pan, Rui; Chen, Xiao; Chen, Yu; Lu, Ting

doi:10.1007/s12265-022-10332-y

J. of Cardiovasc. Trans. Res.

2022

DOI: 10.1007/s12265-022-10332-y

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Association Between the Early Serum Lipid Metabolism Profile and Delayed Neurocognitive Recovery After Cardiopulmonary Bypass in Cardiac Surgical Patients: a Pilot Study

Jingjing Han

He Huang²,

Zheng Li³

et al.

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2024

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Spatial metabolomics reveals key features of hippocampal lipid changes in rats with postoperative cognitive dysfunction

Lei,

Wan,

Han

et al. 2024

J Cereb Blood Flow Metab

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Postoperative cognitive dysfunction (POCD) is a common complication after cardiac surgery. Numerous evidence suggest that dysregulation of lipid metabolism is associated with cognitive impairment; however, its precise role in the development of POCD is still obscure. In this study, we established a cardiopulmonary bypass (CPB) model in rats and employed the Barnes maze to assess cognitive function, selecting POCD rats for subsequent experimentation. Utilizing mass spectrometry imaging, we detected plenty of lipids accumulates within the hippocampal CA1in the POCD group. Immunofluorescence staining revealed a significant reduction in the fluorescence intensity of calcium-independent phospholipases A2 (iPLA2) in the POCD group compared to the control, while serine palmitoyl transferase (SPT) was markedly increased in the POCD group. Transmission electron microscopy revealed that the number of synapses in hippocampal CA1decreased significantly and postsynaptic density became thinner in POCD group. Furthermore, after reversing the metabolic disorders of iPLA2 and SPT in the rat brain with docosahexaenoic acid and myriocin, the incidence of POCD after CPB was significantly reduced and the disrupted lipid metabolism in the hippocampus was also normalized. These findings may offer a novel perspective for exploring the etiology and prevention strategies of POCD after CPB.

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Spatial metabolomics reveals key features of hippocampal lipid changes in rats with postoperative cognitive dysfunction

Lei,

Wan,

Han

et al. 2024

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

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Association Between the Early Serum Lipid Metabolism Profile and Delayed Neurocognitive Recovery After Cardiopulmonary Bypass in Cardiac Surgical Patients: a Pilot Study

Cited by 1 publication

References 29 publications

Spatial metabolomics reveals key features of hippocampal lipid changes in rats with postoperative cognitive dysfunction

Spatial metabolomics reveals key features of hippocampal lipid changes in rats with postoperative cognitive dysfunction

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