Association Between the Hypertriglyceridemic Waist Phenotype, Prediabetes, and Diabetes Mellitus Among Adults in Puerto Rico

Abstract

Background This study assessed the association of the hypertriglyceridemic waist (HTGW) phenotype with prediabetes and diabetes (DM) in a group of Hispanics. Methods Analysis of a cross-sectional study of 858 adults residing in Puerto Rico that collected data on blood pressure, biochemical, and anthropometric measurements was performed. HTGW phenotype was defined as elevated triglycerides and elevated waist circumference. Prediabetes was defined as a fasting glucose of 100–125 mg/dL and DM as a fasting glucose ≥126 mg/dL or prior diagnosis. Results Prevalence of HTGW, prediabetes and DM was 27.9%, 38.0% and 21.6%, respectively. Subjects with the HTGW phenotype had higher adjusted odds of prediabetes (POR=5.55; 95% CI=3.38–9.13) and DM (POR=7.28; 95% CI=3.63–14.63) compared to those without the phenotype. The association for prediabetes was stronger for women than among men. Discussion HTGW phenotype was strongly associated with prediabetes and DM, reinforcing the need to further assess its performance as a screening tool to identify at-risk individuals for cardiometabolic conditions.

Utility of hypertriglyceridemic waist phenotype for predicting incident type 2 diabetes: The Isfahan Diabetes Prevention Study

“…The present findings are consistent with several cross‐sectional data showing that the HTW is an independent predictor of type 2 diabetes. In cross‐sectional study of Canadian Inuits, Canadian Aboriginals, a group of Hispanics and a Chinese population, the HTW was associated with increased risk of type 2 diabetes. Just a few cohort studies have assessed the risk of type 2 diabetes based on the HTW, and the present results are also consistent with them.…”

“…Previous observations also showed that the HTW is a marker of type 2 diabetes, as high levels of TG and enlarged WC are two key metabolic abnormalities associated with type 2 diabetes. The present findings are consistent with several cross‐sectional data showing that the HTW is an independent predictor of type 2 diabetes. In cross‐sectional study of Canadian Inuits, Canadian Aboriginals, a group of Hispanics and a Chinese population, the HTW was associated with increased risk of type 2 diabetes.…”

“…WC has also been advocated in the literature as a valuable type 2 diabetes prediction tool. Previous observations also showed that the HTW is a marker of type 2 diabetes, as high levels of TG and enlarged WC are two key metabolic abnormalities associated with type 2 diabetes. The present findings are consistent with several cross‐sectional data showing that the HTW is an independent predictor of type 2 diabetes.…”

“…The potential clinical utility of visceral lipid accumulation, defined as the hypertriglyceridemic waist (HTW) phenotype (a combination of abdominal obesity and elevated fasting triglycerides), to identify individuals with cardiovascular disease was first reported by Lemieux et al in 2007 7 . Their results have been replicated for predicting type 2 diabetes in other cross-sectional studies involving racial/ ethnic groups, such as Koreans 10,11 , Chinese 5,10,12,13 , Hispanics 14 , Indigenous Australians 15 , elderly Swedish men 16 and Canadian Inuits 17 . However, these studies are cross-sectional in which it is difficult to derive HTW from the etiology of type 2 diabetes.…”

“…in 2007. Their results have been replicated for predicting type 2 diabetes in other cross‐sectional studies involving racial/ethnic groups, such as Koreans, Chinese, Hispanics, Indigenous Australians, elderly Swedish men and Canadian Inuits. However, these studies are cross‐sectional in which it is difficult to derive HTW from the etiology of type 2 diabetes.…”