Association of Abdominal Circumference with Serum Nitric Oxide Concentration in Healthy Population

Kondo, Takaaki; Ueyama, Jun; Imai, Ryota; Suzuki, Kôji; Ito, Yoshinori

doi:10.1265/ehpm.11.321

Cited by 5 publications

(8 citation statements)

References 28 publications

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“…Recent studies have suggested that endothelial NOmediated vasorelaxation is impaired in MetS (28). Although the results are controversial, high serum NOx level seems as an independent predictor of incident MetS and it may be a potential biomarker for assessing cardiometabolic disturbances (29)(30)(31)(32) The major finding of the present study was sLOX-1 levels were positively correlated with oxLDL, ET-1, and BMI. We found that both eNOS and NOx are lower in MetS patients.…”

Section: Discussionmentioning

confidence: 50%

Soluble Lectin‐Like Oxidized LDL Receptor 1 as a Possible Mediator of Endothelial Dysfunction in Patients With Metabolic Syndrome

Civelek

Kutnu

Uzun

et al. 2014

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 50%

Soluble Lectin‐Like Oxidized LDL Receptor 1 as a Possible Mediator of Endothelial Dysfunction in Patients With Metabolic Syndrome

Civelek

Kutnu

Uzun

et al. 2014

Clinical Laboratory Analysis

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“…In a clinical-epidemiological setting, Konukoglu et al [11] suggested that the circulating NO level was lower in obese female subjects with hypertension than in the normal control subjects. Moreover, Kondo et al [12] found that a reduction in NO bioactivity occurs with abdominal fat accumulation in women.…”

Section: Introductionmentioning

confidence: 99%

Association of serum NO x level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan

Ueyama

Kondo

Imai

et al. 2007

Environ Health Prev Med

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Objectives The aim of this study was to determine whether the serum nitrite plus nitrate (NO x ) level correlates with biomarkers that are known components of the metabolic syndrome (MetS). Methods Serum NO x levels were measured using a commercial kit in 608 Japanese men and women between the ages of 39 and 85 years. Multivariate adjustments for age, smoking status, alcohol consumption and exercise were made in the analysis of covariance (ANCOVA). The components of the metabolic syndrome were defined based on the following criteria: body mass index (BMI) C25.0 kg/m 2 , glycated hemoglobin (HbA1c) C5.6%, systolic blood pressure C130 mmHg or diastolic blood pressure C85 mmHg, high-density lipoprotein-cholesterol (HDL-C) B1.03 mmol/l for men and B1.29 mmol/l for women and triglyceride C1.69 mmol/l. Results The logarithmically transformed age-adjusted serum NO x (lnNO x ) value was significantly higher in the low HDL-C group (1.76 ± 0.05 lmol/l; p \ 0.05) than MetS component groups (1.65 ± 0.01 lmol/l) in men, but no difference was found in women. The means of serum lnNO x after multivariate adjustment were 1.64, 1.65, 1.64, 1.66, and 1.81 lmol/l for 0, 1, 2, 3, and 4-5 MetS components for all subjects, respectively. The results of ANCOVA confirmed that the serum lnNO x level was significantly correlated with the clustering of MetS components in both men and women (p \ 0.0001 for trend). Conclusion Our results suggest that an increase in the clustering of MetS components was associated with the increase in serum NO levels in our general population.

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“…Cardiometabolic diseases including obesity, the metabolic syndrome and type II diabetes are major contributors to global CVD disease burden. Whilst some studies have reported plasma nitrate/nitrite levels to be negatively associated with waist circumference 94 , obesity 95 and blood pressure, others have observed positive associations between plasma nitrite and BMI, fasting blood glucose , systolic blood pressure and the fasting lipid profile. In support of these findings, Akram et al (2018) , found plasma nitrite levels to be higher in individuals with both obesity and the metabolic syndrome followed by those with obesity alone, with the lowest levels in those with normal weight.…”

Section: Non-modifiable Factorsmentioning

confidence: 99%

The role of dietary nitrate and the oral microbiome on blood pressure and vascular tone

et al. 2020

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There is increasing evidence for the health benefits of dietary nitrates including lowering blood pressure and enhancing cardiovascular health. Although commensal oral bacteria play an important role in converting dietary nitrate to nitrite, very little is known about the potential role of these bacteria in blood pressure regulation and maintenance of vascular tone. The main purpose of this review is to present the current evidence on the involvement of the oral microbiome in mediating the beneficial effects of dietary nitrate on vascular function and to identify sources of inter-individual differences in bacterial composition. A systematic approach was used to identify the relevant articles published on PubMed and Web of Science in English from January 1950 until September 2019 examining the effects of dietary nitrate on oral microbiome composition and association with blood pressure and vascular tone. To date, only a limited number of studies have been conducted, with nine in human subjects and three in animals focusing mainly on blood pressure. In general, elimination of oral bacteria with use of a chlorhexidine-based antiseptic mouthwash reduced the conversion of nitrate to nitrite and was accompanied in some studies by an increase in blood pressure in normotensive subjects. In conclusion, our findings suggest that oral bacteria may play an important role in mediating the beneficial effects of nitrate-rich foods on blood pressure. Further human intervention studies assessing the potential effects of dietary nitrate on oral bacteria composition and relationship to real-time measures of vascular function are needed, particularly in individuals with hypertension and those at risk of developing CVD.

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Association of Abdominal Circumference with Serum Nitric Oxide Concentration in Healthy Population

Cited by 5 publications

References 28 publications

Soluble Lectin‐Like Oxidized LDL Receptor 1 as a Possible Mediator of Endothelial Dysfunction in Patients With Metabolic Syndrome

Soluble Lectin‐Like Oxidized LDL Receptor 1 as a Possible Mediator of Endothelial Dysfunction in Patients With Metabolic Syndrome

Association of serum NO x level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan

The role of dietary nitrate and the oral microbiome on blood pressure and vascular tone

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