Association of ACE2 Genetic Variants With Blood Pressure, Left Ventricular Mass, and Cardiac Function in Caucasians With Type 2 Diabetes

Patel, Sheila K.; Wai, Bryan; Ord, M.; MacIsaac, Richard J; Grant, Sharon; Velkoska, Elena; Panagiotopoulos, Sianna; Jerums, George; Srivastava, Piyush; Burrell, Louise M.

doi:10.1038/ajh.2011.188

Cited by 80 publications

(79 citation statements)

References 38 publications

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“…23 In Caucasians with type 2 diabetes, genetic variation in ACE2 has been associated with hypertension and reduced systolic function in men, and with hypertension and increased LV mass in women. 24 A significant association with body height was found in cases of both polymorphisms in men, but not in women in our study. Body height was reported to be a determinant of timing and magnitude of reflected arterial pulses.…”

Section: Discussioncontrasting

confidence: 59%

ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography

Vašků

Bienertová-Vašků

Pařenica

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Background and aim: The objective of this research was to determine whether invasively measured central pulse pressure (PP) in patients indicated for coronarography is associated with two common polymorphisms in the ACE2 region (rs4646156 and rs4646174). Methods: A total of 307 patients were enrolled in the study. The genotyping of both SNPs from peripheral blood samples was carried out using 5′exonuclease (Taqman®) chemistry on the ABI Prism® 7000 system (Applied Biosystems, Foster City, CA, USA). Results: In both polymorphisms, the associations with central PP were found to be highly significant when all five possible genotypes in the population had been compared (p = 0.0001). In men, there was a higher incidence of previous myocardial infarction in G0 genotype carriers of rs54646174 (OR ratio = 7; p = 0.005). The AA genotype of rs4646156 had a 7.81× higher risk of severe angina pectoris in women (OR = 7.81, p = 0.05). A significant difference in allelic frequency of ACE2rs4646174 was found between women with and without significant stenoses of the circumflex branch of the left coronary artery. Conclusion: More research into the role of ACE2 genetic variability in PP regulations is necessary for more detailed physiological and pathophysiological comprehension of PP regulation.

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Section: Discussioncontrasting

confidence: 59%

ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography

Vašků

Bienertová-Vašků

Pařenica

et al. 2012

J Renin Angiotensin Aldosterone Syst

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“…39, 40 In humans, several studies have shown a strong association of ACE2 polymorphisms to hypertension in female Chinese patients with metabolic syndrome, 41 essential hypertension 42-45 or diabetes-associated hypertension. 46 Thus, together with biochemical data that ACE2 degrades Ang II to generate Ang1-7, it appears that ACE2 plays a profound role in controlling BP. However, genetic inactivation of ACE2 using homologous recombination results in no apparent alterations in BP in the basal state.…”

Section: Ace2 As a Negative Regulator Of The Ras In The Cardiovasculamentioning

confidence: 97%

Multiple Functions of Angiotensin-Converting Enzyme 2 and Its Relevance in Cardiovascular Diseases

Kuba

Imai

Penninger

2013

Circ J

179

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“…[19][20][21] It is not clear whether ACE2 gene variants influence the retinopathy progress in T2DM cohort. In this study, we analyzed these two SNPs in the ACE2 gene in T2DM patients.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 ACE2 is highly expressed in normal kidney, heart, and retina. 15,17,18 Previous studies on single nucleotide polymorphisms (SNPs, rs2074192 and rs714205) in ACE2 gene and diabetic nephropathy or hypertension were conducted; [19][20][21] however, only SNP rs2074192 was reported to be associated with diabetic hypertension in male individuals, no association was found between the two SNPs in ACE2 gene and diabetic nephropathy in either men or women. It is not clear whether ACE2 gene variants influence the retinopathy progress in T2DM cohort, and whether gender is involved.…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms of angiotensin I converting enzyme 2 with retinopathy in type 2 diabetes mellitus among Chinese individuals

Meng

Zhang

et al. 2014

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Aims To examine the association of Angiotensin I converting enzyme 2 (ACE2) gene polymorphisms and retinopathy in a Chinese type 2 diabetes mellitus (T2DM) cohort. Methods A total of 743 T2DM participants were involved in this study including 408 female and 335 male cases. Female cases were divided into two groups: diabetes without retinopathy (DNR group, n ¼ 171) and with retinopathy (DR group, n ¼ 237), the latter was further subclassified into nonproliferative DR (NPDR group, n ¼ 121) and proliferative DR (PDR group, n ¼ 116). Male cases were assigned to DNR group (n ¼ 153) and DR group (n ¼ 182) which was further grouped into NPDR group (n ¼ 86) and PDR group (n ¼ 96). Two single nucleotide polymorphisms (SNPs; rs2074192 and rs714205) in ACE2 gene were genotyped. Results In female cases, the frequency of genotypes TT in rs2074192 and CC in rs714205 were higher in DR and PDR group than in DNR group (Po0.05). The frequency of alleles T in SNP rs2074192 and C in SNP rs714205 was higher in DR group (Po0.05) and PDR group (Po0.05) than in DNR group. The frequency of allele T in SNP rs2074192 was higher in PDR group (P ¼ 0.04) than in NPDR group. The frequency of haplotype TC and CG was higher in DR and PDR groups, respectively (Po0.05). No positive results were found in male cases. Conclusions Our results revealed that SNPs rs2074192 and rs714205 in ACE2 gene were associated with the susceptibility of DR and PDR.

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Association of ACE2 Genetic Variants With Blood Pressure, Left Ventricular Mass, and Cardiac Function in Caucasians With Type 2 Diabetes

Abstract: In Caucasians with type 2 diabetes, genetic variation in ACE2 is associated with hypertension and reduced systolic function in men, and hypertension and increased LV mass in women.

Cited by 80 publications

References 38 publications

ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography

ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography

Multiple Functions of Angiotensin-Converting Enzyme 2 and Its Relevance in Cardiovascular Diseases

Association of polymorphisms of angiotensin I converting enzyme 2 with retinopathy in type 2 diabetes mellitus among Chinese individuals

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