Association of Adiponectin Gene Polymorphisms With the Risk of Coronary Artery Disease in Patients With Nonalcoholic Fatty Liver Disease in a Chinese Han Population

Abstract

BackgroundCardiovascular events are an independent risk factor for nonalcoholic fatty liver disease (NAFLD), which is the leading cause of mortality in NAFLD patients. Several recent studies demonstrated that adiponectin (Ad) polymorphisms were involved in the progression of NAFLD and coronary artery disease (CAD). However, reports on the association between Ad polymorphisms and the risk of developing CAD in NAFLD patients are lacking in a Northern Han Chinese population.ObjectivesThe present study was designed to evaluate the association between Ad gene polymorphisms (rs266729 and rs2241766) and the risk of developing CAD in Northern Han Chinese patients with NAFLD.Materials and MethodsIn this case-control study, using the polymerase chain reaction (PCR), Adrs266729 and rs2241766 gene polymorphisms were genotyped in B-type ultrasonography-proven NAFLD patients, with (n = 246) or without (n = 247) CAD and in healthy controls (n = 304). Serum lipid profiles were determined using biochemical methods. Statistical analyses were performed using SPSS 17.0 statistical software.ResultsThere were significant differences in the Adrs266729 G allele between the NAFLD patients with and without CAD (P < 0.05). In addition, there was a significant difference in the Adrs2241766 G allele of the NAFLD patients compared with that of the controls (P < 0.05). In the NAFLD CAD population, carriers of the G allele of Adrs266729 had higher serum triglycerides (TG), total cholesterol (TC), fasting plasma glucose (FPG), and low-density lipoprotein (LDL) levels and a lower Ad level than their noncarrier counterparts (P = 0.031, P = 0.034, P = 0.007, P < 0.001, and P < 0.001, respectively). NAFLD patients without CAD had higher TG and serum FPG values and a lower Ad level than their noncarrier counterparts (P = 0.014, P = 0.038, and P < 0.001, respectively). In the NAFLD patients with/without CAD, the carriers of the G allele of Adrs2241766 had higher TG levels (P = 0.039 and P = 0.042, respectively) than those of their noncarrier counterparts.ConclusionsIn this Northern Chinese Han population, the Adrs266729 and rs2241766 G alleles were closely associated with the occurrence of NAFLD. However, only NAFLD patients who carried the Adrs266729 G allele had an increased risk of developing CAD.

Correlation Between Adiponectin Gene rs1501299 Polymorphism and Nonalcoholic Fatty Liver Disease Susceptibility: A Systematic Review and Meta-Analysis

“…In addition to that, leptin receptor Q223R A allele significantly reduced the risk of NAFLD [36]. With regard to adiponectin, it was reported that rs266729 and rs2241766 G alleles were closely associated with the progression of NAFLD [37]; rs822393 (–4522 C/T) polymorphism was correlated with increased risk of NAFLD as well [38]. There is no doubt that the study of adiponectin is a hot topic among these influencing factors.…”

Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

“…For rs266729 (− 11,377 C/G) in ADIPOQ , Du et al [ 39 ] and Zhang et al [ 40 ] found that the SNP is associated with CVD risk; Stenvinkel et al [ 41 ] revealed that rs266729 is associated with the decreased risk of CVD; Zhang et al [ 40 ], Cheong et al [ 27 ], and Chiodini et al [ 29 ] found that there is no significant association between rs266729 and CVD. For rs2241766 (+ 45 T/G), Pischon et al [ 42 ] and Jung et al [ 43 ] identified no association between rs2241766 and the risk of coronary artery disease (CAD) in patients with type 2 diabetic mellitus (T2DM); Du et al [ 39 ], Oliveira et al [ 44 ], and Mofarrah et al [ 45 ] found that there is a significant association between rs2241766 polymorphism and CAD risk; Chang et al [ 46 ] revealed that rs2241766 is associated with the decreased risk of CVD. Moreover, for rs1501299 (+ 276 G / T), Bacci et al [ 47 ] and Esteghamati et al [ 48 ] revealed that rs1501299 is associated with the decreased risk of CAD; Mohammadzadeh et al [ 38 ], however, reported that there is an association between rs1501299 and CAD risk; Foucan et al [ 49 ] found that there is no significant association between rs1501299 and CAD in patients with T2DM.…”

Role of NCAN rs2228603 polymorphism in the incidence of nonalcoholic fatty liver disease: a case-control study

“…It is considered that the main course of the death in patients with NAFLD is from coronary events [16–18]. Cardiovascular disease accounted for about 25% deaths in patients with NAFLD [19, 20]. The pathogenesis of NAFLD is still a complex disorder and multifaceted process which remains under investigation.…”