Association of aortic vascular uptake of 18FDG by PET/CT and aortic wall thickness by MRI in psoriasis: a prospective observational study

Groenendyk, Jacob; Shukla, Parag; Dey, Amit; Elnabawi, Youssef; Aksentijevich, Milena; Choi, Harry; Genovese, Leonard; Harrington, Charlotte; Natarajan, Balaji; Goyal, Aditya; Reddy, Aarthi; Rodante, Justin; Kabbany, Mohammad Tarek; Sadek, Ahmed; Najafi, Mina Al; Playford, Martin P.; Joshi, Aditya; Ahlman, Mark A.; Gelfand, Joel M.; Bluemke, David A.; Mehta, Nehal N.

doi:10.1007/s00259-019-04454-w

Cited by 11 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In psoriasis increased aortic vascular uptake of 18 F-FDG can be measured. 22 Epicardial adipose tissue (EAT) can be measured by native CT, MRI, and transthoracic echocardiography (TTE). 23 Previous studies have documented a strong association between EAT, obesity, and ASCVD, including CAD.…”

Section: Monitoring Atherosclerosis In Psoriasismentioning

confidence: 99%

See 1 more Smart Citation

Novel anti‐inflammatory therapies to reduce cardiovascular burden of psoriasis

Piros

Szilveszter

Vattay

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

Psoriasis mainly affects the skin and joints and has serious impacts on the physical, emotional, and financial life of patients. Recent studies have demonstrated that other comorbidities are frequently detected in psoriatic patients. A strong association with the development of cardiovascular diseases, such as hypertension, myocardial infarction, and stroke is responsible for the shortened (by 4.5‐5 years) life expectancy of severe psoriatic patients. Systemic inflammation plays an important role in the interrelationship between psoriasis and atherosclerotic plaque formation, which is a common immunopathogenic pathway that explains the multiorgan involvement in psoriasis. As far life‐threatening cardiovascular diseases are very often symptom‐free, the treating dermatologist's responsibility is to initiate interdisciplinary holistic patient care, which may lead to directly saved patients' lives. Holistic care of severe psoriatic patients should include regular cardiac monitoring using cardiovascular imaging modalities and functional testing to detect even subclinical coronary artery disease. Effective anti‐inflammatory treatment with biologic therapies may have beneficial effects on the cardiovascular state and may reduce the incidence of cardiac events. The authors review the latest findings on the shared immunopathogenic background of psoriasis and cardiovascular diseases and discuss the available data about the cardiovascular responses to the currently used biologic treatments.

show abstract

Section: Monitoring Atherosclerosis In Psoriasismentioning

confidence: 99%

“…SA can be identified through aortic uptake of 18 FDG by PET/CT and aortic wall thickness measurement by magnetic resonance imaging (MRI). In psoriasis increased aortic vascular uptake of 18 F‐FDG can be measured 22 …”

Section: Monitoring Atherosclerosis In Psoriasismentioning

confidence: 99%

Novel anti‐inflammatory therapies to reduce cardiovascular burden of psoriasis

Piros

Szilveszter

Vattay

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…Patients with vascular inflammation detected by FDG-PET have an increased risk of developing MACE, independent of traditional risk factors. 13 In patients with psoriasis, the degree of aortic inflammation by FDG-PET has been associated with the severity of psoriatic skin lesions 14 and correlates with atherosclerotic disease burden defined by aortic wall thickness measured by MRI 15 and coronary artery plaque build-up by CT angiography. 10,16 A handful of studies have also assessed if reducing the severity of psoriatic skin lesions leads to a decrease in surrogate imaging markers of ASCVD including FDG-PET.…”

mentioning

confidence: 99%