Association of apolipoprotein A5 gene variants with metabolic syndrome in Tunisian population

Kéfi, Rym; Hechmi, Meriem; Dallali, Hamza; Elouej, Sahar; Jmel, Haifa; Halima, Yossra Ben; Nagara, Majdi; Chargui, Mariem; Fadhel, Sihem Ben; Romdhane, Safa; Kamoun, Inès; Turki, Z.; Abid, Abdelmajid; Bahri, Sonia; Bahlous, Afaf; Gomis, Ramón; Baraket, Abdelhamid; Grigorescu, Florin; Normand, Christophe; Jamoussi, H.; Abdelhak, Sonia

doi:10.1016/j.ando.2017.01.005

Cited by 14 publications

(19 citation statements)

References 36 publications

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“…APOA5 has been implicated in the development of MetS in many studies [15,19,21]. According to the last report brought by the World Health Organization MetS among other non-communicable diseases would be the leading cause of deaths internationally [29].…”

Section: Discussionmentioning

confidence: 99%

“…We studied the linkage disequilibrium (LD) between the APOA5 variants rs651821 and rs3135506 analyzed in our previous study [19] and the APOA5 variant rs662799 analyzed in the present study. r2 index was estimated for all pairs of polymorphisms.…”

Section: Haplotype Association and Linkage Disequilibriummentioning

confidence: 98%

“…The investigated common data are related to two genotyped APOA5 gene variants: rs662799 and rs3135506 in the Tunisian and the Moroccan populations. We pooled the overall effect of rs662799 and rs3135506 on MetS risk for 594 Tunisians (299 controls and 295 patients) and 281 Moroccan (105 controls and 176 patients) [19,20] (Table 7). The pooled OR showed a significant association of the SNP rs3135506 (OR = 1.41, p = 0.015, P Heterogeneity= 0.16 and I 2 = 49.57%) and the SNP rs662799 (OR = 1.75, p<10 −3 ; P Heterogeneity= 0.12 and I 2 = 57.97% with MetS (fixed effect).…”

Section: Meta-analysismentioning

confidence: 99%

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Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

et al. 2020

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Apoliprotein protein A5 (APOA5) has been linked to metabolic syndrome (MetS) in several populations. In North Africa, only the Tunisian and Moroccan populations were investigated. Our aim is to assess the association between APOA5 gene variant (rs662799) and haplotypes with MetS in Tunisian population and to perform a meta-analysis in North Africa. A total of 594 Tunisian participants were genotyped for polymorphism rs662799 using KASPar technology. Two polymorphisms rs3135506 and rs651821 in APOA5 gene genotyped in our previous study, were used in addition to rs662799 to assess the haplotype association with MetS. The genotype of 875 participants was used for the meta-analysis. Statistical analyses were performed with R software. The rs662799 increases the risk of MetS under the dominant (p= 0.018) and the additive models (p= 0.028) in the Tunisian population. After stratification of the cohort following the sex and the geographic origin, a positive association of rs662799 with MetS was found for participant from the Northern region and for the women group. Only the haplotype AGT showed a significant association with MetS by decreasing the risk of the disease.The meta-analysis reported a significant association of rs662799 and rs3135506 with MetS.Our results showed a significant association between the APOA5 gene variants rs662799 and haplotypes with MetS and its traits in Tunisia. An impact of the sex and the geographic origin on the genotype distribution was highlighted. Our funding emphasizes the role of APOA5 in the development of MetS in North Africa.

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Section: Discussionmentioning

confidence: 99%

Section: Haplotype Association and Linkage Disequilibriummentioning

confidence: 98%

Section: Meta-analysismentioning

confidence: 99%

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Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

et al. 2020

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“…However, recent advances in genome-wide association studies (GWAS) have provided a fairly good view of the contribution of APOA5 variants to dyslipidemia in several populations (Talmud, 2007 ; Li et al, 2014 ; Zubair et al, 2016 ; Kefi et al, 2017 ; Sumegi et al, 2017 ). The minor allele of several common APOA5 SNPs such as rs662799 (-1131T>C) and rs3135506 (S19W) have been reported to be consistently and significantly associated with plasma triglyceride (TG) levels (Baum et al, 2003 ; Chaaba et al, 2005 ) and the risk of cardiovascular disease (Talmud et al, 2002 ; Lai et al, 2004 ) in several populations.…”

Section: Introductionmentioning

confidence: 99%

“…Few studies have provided full sequence analysis of the APOA5 gene locus and limited studies have been conducted on APOA5 variants and their possible associations among Arab countries (Chaaba et al, 2005 ; Ouatou et al, 2014 ; Kefi et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Sequence Analysis of APOA5 Among the Kuwaiti Population Identifies Association of rs2072560, rs2266788, and rs662799 With TG and VLDL Levels

et al. 2018

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Common variants of Apolipoprotein A5 (APOA5) have been associated with lipid levels yet very few studies have reported full sequence data from various ethnic groups. The purpose of this study was to analyse the full APOA5 gene sequence to identify variants in 100 healthy Kuwaitis of Arab ethnicities and assess their association with variation in lipid levels in a cohort of 733 samples. Sanger method was used in the direct sequencing of the full 3.7 Kb APOA5 and multiple sequence alignment was used to identify variants. The complete APOA5 sequence in Kuwaiti Arabs has been deposited in GenBank (KJ401315). A total of 20 reported single nucleotide polymorphisms (SNPs) were identified. Two novel SNPs were also identified: a synonymous 2197G>A polymorphism at genomic position 116661525 and a 3′ UTR 3222 C>T polymorphism at genomic position 116660500 based on human genome assembly GRCh37/hg:19. Five SNPs along with the two novel SNPs were selected for validation in the cohort. Association of those SNPs with lipid levels was tested and minor alleles of three SNPs (rs2072560, rs2266788, and rs662799) were found significantly associated with TG and VLDL levels. This is the first study to report the full APOA5 sequence and SNPs in an Arab ethnic group. Analysis of the variants identified and comparison to other populations suggests a distinctive genetic component in Arabs. The positive association observed for rs2072560 and rs2266788 with TG and VLDL levels confirms their role in lipid metabolism.

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Cardio-metabolic risk factors in Tunisia: state of the art

Kéchida

2019

Intern Emerg Med

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Association of apolipoprotein A5 gene variants with metabolic syndrome in Tunisian population

Cited by 14 publications

References 36 publications

Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

Sequence Analysis of APOA5 Among the Kuwaiti Population Identifies Association of rs2072560, rs2266788, and rs662799 With TG and VLDL Levels

Cardio-metabolic risk factors in Tunisia: state of the art

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