Association of Apolipoprotein E (ApoE) Polymorphism with Alzheimer';s Disease in Chinese Population

Zheng, Lingling; Duan, Jianzhong; Duan, Xiaoling; Zhou, Weitao; Chen, Chunjiang; Li, Yanhua; Chen, Jie; Zhou, Weihui; Wang, Yanjiang; Li, Tingyu; Song, Weihong

doi:10.2174/1567205013666160401115307

Cited by 15 publications

(7 citation statements)

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“…The APOE gene polymorphism is associated with the risk of developing many central nervous system disorders. APOE polymorphism has been recognized as a genetic risk factor for the development of Alzheimer's disease in different populations ( Achouri-Rassas et al, 2015 , Kumar et al, 2015 , Zheng et al, 2016 ). In Chinese population, APOE polymorphism is associated with the risk of developing deep venous thrombosis ( Zhu et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis

et al. 2016

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Subarachnoid haemorrhage (SAH) is characterised by bleeding in the subarachnoid space in the brain. There are various polymorphisms in genes which are associated with this disease. We performed a systematic meta- analysis to investigate the relationship of APOE polymorphism on aSAH. A comprehensive literature search was done in the Pubmed database, Science Direct, Cochrane library and Google Scholar. The OR and 95% CI were evaluated for the gene and aSAH association using fixed and random effect models. Publication bias was assessed using Begg's funnel plot and Egger's regression test. All statistical evaluations were done using the software Review Manager 5.0 and Comprehensive Meta Analysis v2.2.023. A total of 9 studies were assessed on APOE polymorphism (1100 Cases, 2732 Control). Meta analysis results showed significant association in ε2/ ε2 versus ε3/ε3, ε2 versus ε3 genetic models and ε2 allele frequency. In subgroup analysis statistically significant association was observed in Asians in the genetic models ε2/ ε2 versus ε3/ε3, ε2/ε3 versus ε3/ε3, ε2 versus ε3 and also in ε2 allele frequency. However, in Caucasian population only ε2/ε2 versus ε3/ε3 genetic model showed significant association between APOE and risk of aSAH. In this meta-analysis study, the ε2/ε2 genotype is associated with increased risk of aSAH.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis

et al. 2016

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“…A study conducted in 11,884 twins has shown that genetic predisposition accounts for 58-79% of Alzheimer's disease cases (Gatz et al, 2006). Previous studies have indicated that genetic polymorphisms in protein tyrosine kinase 2b, presenilin 2, apolipoprotein E, cytochrome 46A1, disrupted-in-schizophrenia-1, 3-hydroxy-3-methylglutaryl-CoA reductase, and sortilin receptor 1 all play essential roles in the development of this disease (Chang et al, 2016;Huang et al, 2016;Jia et al, 2016;Li et al, 2016;Suzuki et al, 2016;Zhang et al, 2016;Zheng et al, 2016). Previous studies have reported that alcohol consumption is associated with risk of Alzheimer's disease (Piazza-Gardner et al, 2013;Berntsen et al, 2015;Ilomaki et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

Ma¹,

Lu²

2016

Genet. Mol. Res.

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In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer's disease (OR = 2.54, 95%CI = 1.19-5.41). In addition, ADH1B rs1229984 was also associated with elevated risk of Alzheimer's disease in both dominant (OR = 1.78, 95%CI = 1.09-2.93) and recessive (OR = 2.33, 95%CI = 1.18-4.57) models. For ALDH2 rs671, the AA genotype was correlated with an increased risk of Alzheimer's disease as compared to the GG genotype (OR = 4.57, 95%CI = 1.60-14.01). The ALDH2 rs671 polymorphism was associated with Alzheimer's in both dominant (OR = 1.79, 95%CI = 1.08-2.97) and recessive (OR = 4.17, 95%CI = 1.49-12.67) models. In conclusion, we observed that ADH1B rs1229984 and ALDH2 rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.

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“…APOE is a well-known apolipoprotein that functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (44). As a secreted protein, APOE has been implicated in lipoprotein metabolism and the pathogenesis of Alzheimer's disease and atherosclerosis (45)(46)(47). However, its association with tumors has rarely been reported.…”

Section: Discussionmentioning

confidence: 99%

Integrated bioinformatics analysis of the association between apolipoprotein E expression and patient prognosis in papillary thyroid carcinoma

et al. 2020

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The prognosis of most patients with papillary thyroid carcinoma (PTC) is excellent despite some cases of tumor progression or relapse. The present study was designed to reveal possible prognostic risk indicators for PTC. Differentially expressed genes (DEGs) extracted from 4 Gene Expression Omnibus (GEO) cohorts were subjected to functional enrichment analyses by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway analysis. A dataset from The Cancer Genome Atlas (TCGA) was obtained to filter and validate significant genes using cytoHubba, followed by analysis of their association with clinicopathological characteristics and prognosis. In total, 240 DEGs were identified after data preprocessing. These DEGs were enriched in 'intracellular redox equilibrium', 'release of exosome', 'cell adhesion', 'regulation of extracellular matrix', 'collagen binding' and 'energy metabolism' based on GO analysis which including cellular component, molecular function and biological process. KEGG pathway analysis revealed that the DEGs were enriched in thyroid hormone synthesis, pathways in cancer, focal adhesion, metabolic pathways, apoptosis, PPAR signaling pathway and PI3K/AKT signaling pathway. Using cytoHubba, the following hub genes were identified: Apolipoprotein E (APOE); hemoglobin subunit α1 (HBA1); angiotensin II receptor 1 (AGTR1); collagen I α1 (COL1A1); galectin 3 (LGALS3) and TIMP metallopeptidase inhibitor 1 (TIMP1). The expression of these genes was found to be consistent in TCGA datasets. Kaplan-Meier analysis revealed that APOE was significantly associated with overall survival (P=0.00067) and disease free survival (P=0.00220). Additionally, low expression of APOE was significantly associated with older age (P<0.001) and higher TNM stage (P<0.001) compared with the high expression group. Therefore, APOE may function as a predictive risk indicator for progression as well as prognosis of PTC.

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Association of Apolipoprotein E (ApoE) Polymorphism with Alzheimer';s Disease in Chinese Population

Cited by 15 publications

References 0 publications

Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis

Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis

Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease

Integrated bioinformatics analysis of the association between apolipoprotein E expression and patient prognosis in papillary thyroid carcinoma

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