Association of both prenatal and early childhood multiple metals exposure with neurodevelopment in infant: A prospective cohort study

Liu, Chaoqun; Huang, Lulu; Huang, Shengzhu; Wei, Luyun; Cao, Dehao; Zan, Gaohui; Tan, Yanli; Wang, Sida; Yang, Minjing; Tian, Long; Tang, Weijun; He, Caitong; Shen, Chunhua; Luo, Bangzhu; Zhu, Maoling; Liang, Tao; Pang, Baohong; Li, Mujun; Mo, Zengnan; Yang, Xiaobo

doi:10.1016/j.envres.2021.112450

Cited by 37 publications

(13 citation statements)

References 83 publications

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“…Children with scores between 30 and 36 are considered to having mild to moderate autism, and those with scores between 37 and 60 are considered severe autism. Neurodevelopmental levels of children with ASD were evaluated using the Gesell Developmental Schedules (GDS), which have been widely used to evaluate the development of children aged from 16 days to 6 years (Liu et al, 2016 , 2022 ). The GDS include five subscales, namely, adaptive, gross motor, fine motor, language, and personal–social behavior.…”

Section: Methodsmentioning

confidence: 99%

Interrelation between homocysteine metabolism and the development of autism spectrum disorder in children

Pang

et al. 2022

Front. Mol. Neurosci.

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Evidence is emerging that dysregulation of circulating concentrations of homocysteine, an important intermediate in folate and vitamin B12 metabolism, is associated with autism spectrum disorder (ASD), but comprehensive assessments and correlations with disease characteristics have not been reported. Multivariate ordinal regression and restricted cubic spline (RCS) models were used to estimate independent correlations between serum homocysteine, folate, and vitamin B12 levels and clinical outcomes and severity of children with ASD. After adjusting for confounding factors, serum homocysteine levels were significantly higher in children with ASD than in healthy controls (β: 0.370; 95% CI: 0.299~0.441, p < 0.001). Moreover, homocysteine had a good diagnostic ability for distinguishing children with ASD from healthy subjects (AUC: 0.899, p < 0.001). The RCS model indicated a positive and linear association between serum homocysteine and the risk of ASD. The lowest quartile of folate was positively associated with ASD severity (OR: 4.227, 95% CI: 1.022~17.488, p = 0.041) compared to the highest quartile, and serum folate showed a negative and linear association with ASD severity. In addition, decreased concentrations of folate and vitamin B12 were associated with poor adaptive behavior developmental quotients of the Gesell Developmental Schedules (p < 0.05). Overall, an increased homocysteine level was associated with ASD in a linear manner and is thus a novel diagnostic biomarker for ASD. Decreased concentrations of folate and vitamin B12 were associated with poor clinical profiles of children with ASD. These findings suggest that homocysteine-lowering interventions or folate and vitamin B12 supplementation might be a viable treatment strategy for ASD.

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Section: Methodsmentioning

confidence: 99%

Interrelation between homocysteine metabolism and the development of autism spectrum disorder in children

Pang

et al. 2022

Front. Mol. Neurosci.

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“…Values below LOQ were replaced by half the LOQ for analysis. The present study aimed to study a bigger set of metals, such as antimony, cobalt, and cadmium, which could induce adverse pregnancy outcomes [29][30][31][32]. However, we had to withdraw them from statistical analysis due to a signi cant number of undetectable concentrations.…”

Section: Metal Exposure Assessmentmentioning

confidence: 99%

Prenatal Exposure to Metal Mixture and Birth Weight; a Bayesian Kernel Machine Regression Analysis of Two Cohort Studies in Japan and Iran

Vigeh,

Yokoyama,

Nishioka

et al. 2024

Preprint

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Purpose Potentially toxic metals can directly induce various adverse effects on reproductive organs or interrupt essential metals' physiological activities. Despite intensive efforts to reduce these metals in the environment, chronic and low-level exposure remains a public health problem. The present study aimed to investigate prenatal metal exposure, including arsenic (As), copper (Cu), lead (Pb), manganese (Mn), rubidium (Rb), selenium (Se), and zinc (Zn), effects on birth weight. Methods We collected 579 blood samples before the 16th week of gestation from apparently healthy women with singleton pregnancy in Iran and Japan. Blood metal concentrations were measured using inductively coupled plasma-mass spectrometry. Results Prenatal blood levels of As, Mn, Pb, and Zn were significantly higher, while Cu, Rb, and Se were significantly (p < 0.01) lower in Iranian participants than in Japanese. Adjusted linear regression analyses and Bayesian Kernel Machine Regression (BKMR) overall exposure-response functions showed inverse relationships between metals and birth weight. Conclusion The study findings, using data from geographically diverse countries, suggest prenatal blood metal exposure as a potential risk factor for lower birth weight. Therefore, women of reproductive age should minimize encountering to potentially toxic metals as much as possible.

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“…Prenatal exposure to metals has been linked to neurodevelopmental outcomes, with specific metals showing negative associations with motor development [ 106 , 107 , 108 ]. While there is evidence that prenatal exposure to aluminium is associated with lower fine motor developmental quotient (DQ) and that cadmium exposure is linked to lower gross motor DQ [ 109 ], it is important to note that the causal mechanisms underlying these associations are not yet fully understood. Similarly, while lead and mercury have been identified as being neurotoxic at low doses during early development [ 110 ], further research is needed to confirm their direct impact on motor development.…”

Section: Advances In Epigenetics Of Dcd and Its Comorbiditymentioning

confidence: 99%

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

et al. 2023

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Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition’s aetiology.

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Association of both prenatal and early childhood multiple metals exposure with neurodevelopment in infant: A prospective cohort study

Cited by 37 publications

References 83 publications

Interrelation between homocysteine metabolism and the development of autism spectrum disorder in children

Interrelation between homocysteine metabolism and the development of autism spectrum disorder in children

Prenatal Exposure to Metal Mixture and Birth Weight; a Bayesian Kernel Machine Regression Analysis of Two Cohort Studies in Japan and Iran

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

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