Association of C3435T (rs1045642) Polymorphism of the MDR1 Gene with the Increased Risk of Colorectal Cancer in Russian Females from Central Russia

Abstract

The objective of this study was to examine associations of single nucleotide polymorphisms, rs1045642 within the MDR1 gene and rs1799930 within the NAT2 gene, with the risk of colorectal cancer (CRC) in the population of Central Russia. DNA specimens were obtained from 178 patients with CRC (87 males and 91 females) and 327 age-matched healthy controls (179 males and 148 females). Genotyping was performed using real-time PCR. Association of the studied SNPs with the risk of CRC was evaluated using logistic regression analysis. It was demonstrated that MDR1 rs1045642 polymorphism was associated with the increased risk of CRC after correction for gender, age, and smoking (OR = 1.41, 95% CI = 1.09-1.83; P = 0.008). A gender-stratified analysis showed that MDR1 rs1045642 was associated with the increased risk of CRC only in females (OR = 1.62, 95% CI = 1.11-2.35; P = 0.01). In males, no association between MDR1 rs1045642 and CRC was found. Association between MDR1 rs1045642 and the increased risk of colorectal cancer in Russian females from Central Russia was revealed.

Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study

“…Histological types of colorectal cancer in the case group included well-differentiated adenocarcinoma (70.3% of cases), moderately differentiated adenocarcinoma (21.6% of cases), and poorly differentiated adenocarcinoma (8.1% of cases). The control group was recruited from the same population and included healthy blood volunteers and hospital-based patients with no clinical evidence for CRC, as described previously [22,23]. The criterion for inclusion in the control group was the absence of oncological and other chronic diseases.…”

Genetic Variation at the Catalytic Subunit of Glutamate Cysteine Ligase Contributes to the Susceptibility to Colorectal Cancer: A Pilot Study

“…The diagnosis of CRC was veri ed by experienced oncologists based on the results of clinical, laboratory, and instrumental methods. The control group was recruited from the same population and included healthy blood volunteers and hospital-based patients with no clinical evidence for CRC, as described previously [22,23]. The criterion for inclusion in the control group was the absence of oncological and other chronic diseases.…”

Association of L432V (rs1056836) polymorphism of the CYP1B1 gene with the increased risk of colorectal cancer in the population of Central Russia

“…A total of 777 unrelated Russian individuals from the Kursk region was examined; written informed consent was obtained from all participants prior to entering the study. The study included 241 CRC patients (129 males and 112 females) who underwent inpatient treatment at the Kursk Regional Clinical Oncology Center between 2013 and 2017 [6,7]. The control group included 536 healthy volunteers (246 males and 290 females) without a history of chronic diseases.…”