Association of Candidate Genes with Production Traits in Korean Dairy Proven and Young Bulls

Abstract

This study was performed to offer effective basic data for selection and improvement of Korean dairy cattle through identifying distributional properties among candidate genes (bovine butyrophilin, signal transducers and activators of transcription 5a, and prolactin hormone). In this study, polymorphisms of candidate genes were identified and the relationships between loci and production traits of each gene were analyzed using frozen semen of Holstein bulls (19 proven and 77 candidates). In butyrophilin (BTN) locus, polymorphisms information contents (PIC) value of BTN2 (0.372) was higher than those of others (BTN1; 0.155, BTN3; 0.254, BTN4; 0.169). As a result of analysis of genotyping STAT5a, using single stranded conformational polymorphism (SSCP) method and microsatellite locus, PIC values were 0.189 and 0.457, respectively. And PIC value of prolactin hormone gene was 0.176. In the relationships between genotypes and production traits, BTN3 was associated with 305-day production traits (p<0.05). PTAs for B allele were such as 110.43, 88.28 and 75.25 in BTN1, 3, 4 and these values were higher than those of A allele, but in the case of BTN2, A allele with 154.19 was higher than that of B allele. The results obtained from using candidate genes may be used as an useful index for the genetic improvement of dairy cattle population in Korea, and further studies are needed.

Analysis of allelic pattern across milk trait genes in native cattle adapted to high altitude region of Leh-Ladakh

“…Husani et al (1999) reported similar frequency level for allele A (0.850) and B (0.150). The trend of genotypic profile obtained in the present study also corroborates with the earlier study for Korean bulls, where very high prevalence of AA has been reported (Lee et al 2002, Jang et al 2005.…”

“…The frequencies for A and B allele was reported to be 0.891 and 0.109, respectively as against 0.52 and 0.48 observed in the present study. The findings of Jang et al (2005) corroborated with the earlier findings of Chung et al (1998) wherein they have also reported the similar frequencies with respect to AA (0.621) and AB (0.218) genotypes as well as A (0.730) and B allele (0.270). Surprisingly, none of the animals from these studies (Jang et al 2005, Chung et al 1998) exhibited homozygous BB genotype.…”

“…The findings of Jang et al (2005) corroborated with the earlier findings of Chung et al (1998) wherein they have also reported the similar frequencies with respect to AA (0.621) and AB (0.218) genotypes as well as A (0.730) and B allele (0.270). Surprisingly, none of the animals from these studies (Jang et al 2005, Chung et al 1998) exhibited homozygous BB genotype. Also in a study by Dybus et al (2005), the two herds of Black and White Polish cattle presented results contrary to the findings of the present study, wherein AA genotypes was observed with highest frequency (0.7222 and 0.6983) followed by the heterozygous AB genotypes (0.2778 and 0.2931) and BB genotype (0 and 0.0086), which was least represented.…”

“…2). However, this profile was in sharp contrast to what had been reported for 96 Korean bulls (Jang et al 2005). In their study, AA genotype was most predominant with a frequency of 0.781, followed by AB genotype (0.219).…”

Analysis of Genetic Variation at the Prolactin-RsaI (PRL-RsaI) Locus in Indian Native Cattle Breeds (Bos indicus)

“…Contrary to the present observations (PRL A frequency 0.52), several studies have reported a higher frequency of the PRL A allele in European Holstein (0.95, Chrenek et al 1998), Korean Holstein (0.73, Chung et al 19960.89, Jang et al 2005), Russian Ayrshire (0.86, Udina et al 2001), andGorbatev Red (0.91, Udina et al 2001) cattle. Studies on Korean Holstein (Chung et al 1996;Jang et al 2005) and two Russian cattle (Udina et al 2001) showed a complete absence of the homozygous BB genotype in these breeds. Dybus et al (2005) also presented a higher frequency of AA genotypes in two herds of Black (0.722) and White Polish (0.698) cattle.…”