Association of CDKN2BAS gene polymorphism with periodontitis and Coronary Artery Disease from South Indian population

Mangalarapu, Madhavi; Vinukonda, Swetha; Komaravalli, Prasanna Latha; Nagula, Praveen; Koduganti, Rekha Rani; Korripally, Premsagar; Sagurthi, Someswar Rao

doi:10.1016/j.gene.2019.06.002

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…Seven papers were duplicated across different databases and were also excluded. Applying inclusion and exclusion criteria, 29 publications were excluded during screening, and nine exclusions occurred during the eligibility phase, which resulted in 34 remaining studies 5,6,8,12–42 (Table 1). Reference lists checking did not yield in new inclusions.…”

Section: Resultsmentioning

confidence: 99%

“…These variables were not present in unfavorable opinions. Genetic variables and mortality were found exclusively in favorable opinions; however, these last two variables were the least frequent in included publications, occurring only in one article 42 for mortality (2.94%) and three articles 5,12,18 for genetic variables (8.82%). Nevertheless, a statistically significant result was not found between the opinions of the studies and the variables, indicating in the context of this scoping review that the variables were not able to influence the opinions of analyzed studies.…”

Section: Discussionmentioning

confidence: 98%

“…Considering the parameters of evidence, for the researched period of time, observational studies 6,8,[12][13][14]16,18,19,[22][23][24][25][26][27][28][29][30][31][33][34][35][36][40][41][42] comprised 73.53% of included studies in the present scoping review, which could be classified as of level II-2 if there were multicentric studies, which did not occur. The analyzed controlled clinical trials, 17,20,21,38,39 which could show level of evidence II-1, were also compromised because two systematic reviews of controlled clinical trials 15,37 were uncertain regarding the relation between PD and CAD, as well as demonstrated a high risk of bias of analyzed studies.…”

Section: Discussionmentioning

confidence: 99%

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Is there evidence that periodontal diseases are risk factors for coronary arterial disease?—Scoping review

Silva

Aguiar

Gomes

et al. 2020

Special Care in Dentistry

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Aim: To determine the scientific evidence regarding the condition of periodontal diseases (PDs) as risk factors of coronary artery diseases. Materials and methods:A scoping review was performed through the selection of articles from online databases (Medline via PubMed, LILACS, and Cochrane CENTRAL), using a search algorithm and eligibility criteria for data extraction and data synthesis of included papers. Four hundred forty-one studies from online databases and 1364 from reference lists were initially identified, and 34 articles were selected for inclusion. Articles had to be published between 2015 and 2020 and had to associate PDs to coronary arterial diseases. All studies comprised a sample of 446443 participants. Favorable opinions totaled 70.59%, and the cross-sectional observational study design was more frequently found (32.35%). Biochemical outcomes were showed more frequently, such as inflammatory biomarkers (58.82%). Despite a large advantage for favorable opinions, a statistically significant result was not found when extracted data were combined with studies opinions. Conclusion:The evidence was classified as level II-3, hence, still distant from the best ranks and can therefore be considered as unclear. Moreover, studies with the higher potential to generate evidence showed a high risk of bias.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Is there evidence that periodontal diseases are risk factors for coronary arterial disease?—Scoping review

Silva

Aguiar

Gomes

et al. 2020

Special Care in Dentistry

View full text Add to dashboard Cite

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“…LncRNA ANRIL is the best replicated genetic risk factor for coronary artery disease and regulates genes involved in fatty acid and glucose metabolism 20 . Previous studies showed that ANRIL was highly expressed in endothelial and may be involved in the thrombogenesis 21,22 . Moreover, increased ANRIL has long been investigated as a potential marker in the plaque of atherosclerosis patients 23 .…”

Section: Discussionmentioning

confidence: 99%

“…20 Previous studies showed that ANRIL was highly expressed in endothelial and may be involved in the thrombogenesis. 21,22 Moreover, increased ANRIL has long been investigated as a potential marker in the plaque of atherosclerosis patients. 23 More and more researchers began to investigate the role of ANRIL in cardiovascular diseases; however, there are little reports about the clinical and prognostic significance of ANRIL in AF with ischemic stroke.…”

Section: Correlation Of Serum Lncrna Anril Expression With Prognosismentioning

confidence: 99%

The correlation of serum long non‐coding RNA ANRIL with risk factors, functional outcome, and prognosis in atrial fibrillation patients with ischemic stroke

Zeng

Jin

2020

Clinical Laboratory Analysis

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Background This study aimed to evaluate the predictive value of long non‐coding RNA (lncRNA) antisense non‐coding RNA in the INK4 locus (ANRIL) for atrial fibrillation (AF) patients with ischemic stroke and investigate its correlation with risk factors, functional outcome, and prognosis. Methods A total of 386 consecutive AF patients were recruited. AF patients were followed up for 24‐48 months by outpatient follow‐up, telephone follow‐up, and medical record. The time of ischemic stroke in patients with AF was recorded, and follow‐up was continued for 6 months. LncRNA ANRIL expression from serum was detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). Results Compared with the AF with ischemic stroke group (14.3 ± 2.3), patients in the AF without ischemic stroke group (11.9 ± 1.8) had significantly lower serum lncRNA ANRIL levels ( P < .05). The sensitivity and specificity of lncRNA ANRIL for identifying AF with ischemic stroke were 76.6% and 81.4%, respectively. Spearman correlation analysis results shown that lncRNA ANRIL was significantly correlated with the NIHSS score ( r Spearman = .490, P < .001) and the mRS score ( r Spearman = .466, P < .001). Compared with the lncRNA ANRIL high‐expression group, the recurrence‐free survival (RFS) of the lncRNA ANRIL low‐expression group was significantly higher ( χ 2 = 11.009, log‐rank P < .001). Cox proportional regression model analysis indicated that the serum lncRNA ANRIL level ( P = .004), NIHSS score ( P = .001), infarct volume ( P = .035), and smoking ( P < .001) were the risk factors for AF with ischemic stroke. Conclusion Serum lncRNA ANRIL exerts a good predictive value for AF with ischemic stroke, and its increased expression is correlated with worse RFS for patients.

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The roles of ANRIL polymorphisms in periodontitis: a systematic review and meta-analysis

Öztürk

Ada

2021

Clin Oral Invest

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Association of CDKN2BAS gene polymorphism with periodontitis and Coronary Artery Disease from South Indian population

Cited by 11 publications

References 29 publications

Is there evidence that periodontal diseases are risk factors for coronary arterial disease?—Scoping review

Is there evidence that periodontal diseases are risk factors for coronary arterial disease?—Scoping review

The correlation of serum long non‐coding RNA ANRIL with risk factors, functional outcome, and prognosis in atrial fibrillation patients with ischemic stroke

The roles of ANRIL polymorphisms in periodontitis: a systematic review and meta-analysis

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