Association of circulating adiponectin with testosterone in women during the menopausal transition

Matsui, Shinji; Tani, Akio; Kato, Takeshi; Kunimi, Kotaro; Uemura, Hirokazu; Kuwahara, Akira; Matsuzaki, Takashi; Irahara, Minoru

doi:10.1016/j.maturitas.2012.08.003

Cited by 20 publications

(7 citation statements)

References 32 publications

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“…In a Caucasian population, higher levels of testosterone and lower estradiol concentrations predicted higher adiponectin levels in both genders [32]. However, in an Asian population, adiponectin levels were negatively correlated with testosterone but were not correlated with estradiol in postmenopausal females (more than 1 year since menopause) [33]. In our study, testosterone and adiponectin showed a significant negative association in the correlation analysis for older females.…”

Section: Discussionmentioning

confidence: 46%

Gender differences in adiponectin levels and body composition in older adults: Hallym aging study

Song

Quan

et al. 2014

BMC Geriatr

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BackgroundBody composition changes with ageing can influence the adiponectin concentration. However, the component of body composition that is associated with adiponectin concentrations in older adults remains unclear.MethodsThere were 152 males and 168 females aged 65 years or older that participated in the 2010 Hallym Aging Study (HAS). Body composition (assessed by dual energy X-ray absorptiometry; DXA), anthropometric parameters and adiponectin were obtained from all participants. Multivariate linear regression models assessed the association of body fat percentage, regional muscle and bone mineral contents of body composition and waist/height ratio with adiponectin concentration. Age, albumin, testosterone concentration and metabolic parameters were considered as confounding factors.ResultsIn correlation analysis, age was positively associated with adiponectin in males (P < 0.01), but not in females. Fasting glucose, albumin, arm skeletal muscle mass and bone mineral content were negatively associated with adiponectin in males (P < 0.05). Testosterone and leg bone mineral content were negatively associated with adiponectin in females (P < 0.05). In multivariate linear regression models, body fat percentage and albumin (P < 0.05) were negatively associated with adiponectin, and high-density lipoprotein cholesterol (HDL-C) (P < 0.001) and age (P < 0.01) were positively associated with adiponectin in older males. In older females, the only factors that correlated significantly with adiponectin concentration were the homeostasis model assessment of insulin resistance (P < 0.001) and HDL-C (P < 0.05). The waist/height ratio and bone mineral content were not associated with adiponectin in either gender.ConclusionPlasma adiponectin levels correlated negatively with body fat percentage in older males but not in older females. The differential results between older males and females suggest that certain gender-specific mechanisms may affect the association between adiponectin and age-related body composition changes.

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Section: Discussionmentioning

confidence: 46%

Gender differences in adiponectin levels and body composition in older adults: Hallym aging study

Song

Quan

et al. 2014

BMC Geriatr

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“…In addition, gender was one of best predictors of adiponectin levels in multiple regression analyses. Adiponectin has been shown to negatively correlate with testosterone levels in both males and females(34, 35). Testosterone therapy in aging men has been reported to decrease SAT and adiponectin levels(36, 37).…”

Section: Discussionmentioning

confidence: 99%

Adiposity distribution influences circulating adiponectin levels

Guenther

James

Marks

et al. 2014

Translational Research

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Thirty percent of obese individuals are metabolically healthy and were noted have increased peripheral obesity. Adipose tissue is the primary source of adiponectin, an adipokine with insulin-sensitizing and anti-inflammatory properties. Lower adiponectin levels are observed in individuals with obesity and those at risk for cardiovascular disease. Conversely, higher levels are noted in some obese individuals who are metabolically healthy. Our objective was to determine whether abdominal adiposity distribution, rather than BMI status, influences plasma adiponectin level. Four-hundred and twenty-four subjects (female: 255) of Northern European ancestry were recruited from “Take Off Pounds Sensibly” (TOPS) weight loss club members. Demographics, anthropometrics, and dual X-ray absorptiometry of the whole body and CT scan of the abdomen were performed to obtain total body fat content and to quantify subcutaneous adipose tissue and visceral adipose tissue respectively. Laboratory measurements included fasting plasma glucose, insulin, lipid panel, and adiponectin. Age- and gender-adjusted correlation analyses showed that adiponectin levels were negatively correlated with body mass index, waist circumference, triglycerides, total fat mass, and visceral adipose tissue. A positive correlation was noted with HDL-cholesterol and fat free mass (p<0.05). Subcutaneous adipose tissue -to-visceral adipose tissue ratios were also significantly associated with adiponectin (r=0.13, p = 0.001). Further, the best positive predictors for plasma adiponectin were found to be subcutaneous adipose tissue -to-visceral adipose tissue ratios and gender by regression analyses (P<0.01). Abdominal adiposity distribution is an important predictor of plasma adiponectin and obese individuals with higher subcutaneous adipose tissue -to-visceral adipose tissue ratios may have higher adiponectin levels.

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“…This change interacts with the hormonal system. Matsui et al described the association of adipocytokines and ghrelin among obese and nonobese women studied at each of the three menopausal stages [60]. They showed that leptin levels increased across menopause in nonobese women; this change was independently associated with FSH level.…”

Section: Sex Hormone Distribution and Adiponectin Concentration Dumentioning

confidence: 99%

“…However, the changes in E2, T, and SHBG concentrations were not predictive of adiponectin concentrations. In addition, adiponectin levels were found to be significantly lower during perimenopause compared to both pre- and postmenopause stages [60]. …”

Section: Sex Hormone Distribution and Adiponectin Concentration Dumentioning

confidence: 99%

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Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women: Controversies

et al. 2014

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The literature reports indicating a link between plasma levels of adiponectin and body fat, bone mineral density, sex hormones, and peri- and postmenopausal changes, draw attention to the possible use of adiponectin as an indicator of osteoporotic changes, suggesting that adiponectin may also modulate bone metabolism. In this study, we attempted to analyze the available in vitro and in vivo results which could verify this hypothesis. Although several studies have shown that adiponectin has an adverse effect on bone mass, mainly by intensifying resorption, this peptide has also been demonstrated to increase the proliferation and differentiation of osteoblasts, inhibit the activity of osteoclasts, and reduce bone resorption. There are still many ambiguities; for example, it can be assumed that concentrations of adiponectin in plasma do not satisfactorily reflect its production by adipose tissue, as well as conflicting in vitro and in vivo results. It seems that the potential benefit in the treatment of patients with osteoporosis associated with the pharmacological regulation of adiponectin is controversial.

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Association of circulating adiponectin with testosterone in women during the menopausal transition

Cited by 20 publications

References 32 publications

Gender differences in adiponectin levels and body composition in older adults: Hallym aging study

Gender differences in adiponectin levels and body composition in older adults: Hallym aging study

Adiposity distribution influences circulating adiponectin levels

Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women: Controversies

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