Association of Corneal Hysteresis With Lamina Cribrosa Curvature in Primary Open Angle Glaucoma

Lee, Kyoung Min; Kim, Tae Woo; Lee, Eun Ji; Girard, M; Mari, Jean Martial; Weinreb, Robert N.

doi:10.1167/iovs.19-27087

Cited by 22 publications

(24 citation statements)

References 47 publications

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“…Recent studies suggest a possible relationship between lower CH values and structural changes in the optic nerve associated with glaucomatous damage. The relationship of low CH values with mean cup depth, linear cup-to-disc ratio, and greater posterior displacement of the lamina cribrosa has been evidenced [44][45][46]. Corneal hysteresis may provide insight into the biomechanical properties of the optic nerve and its supporting structures.…”

Section: Chmentioning

confidence: 99%

Corneal Biomechanical Parameters and Central Corneal Thickness in Glaucoma Patients, Glaucoma Suspects, and a Healthy Population

Buey-Sayas

Lanchares

Campíns‐Falcó

et al. 2021

JCM

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Purpose: To evaluate and compare corneal hysteresis (CH), corneal resistance factor (CRF), and central corneal thickness (CCT), measurements were taken between a healthy population (controls), patients diagnosed with glaucoma (DG), and glaucoma suspect patients due to ocular hypertension (OHT), family history of glaucoma (FHG), or glaucoma-like optic discs (GLD). Additionally, Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated IOP (IOPcc) were compared between the different groups of patients. Methods: In this prospective analytical-observational study, a total of 1065 patients (one eye of each) were recruited to undergo Ocular Response Analyzer (ORA) testing, ultrasound pachymetry, and clinical examination. Corneal biomechanical parameters (CH, CRF), CCT, IOPg, and IOPcc were measured in the control group (n = 574) and the other groups: DG (n = 147), FHG (n = 78), GLD (n = 90), and OHT (n = 176). We performed a variance analysis (ANOVA) for all the dependent variables according to the different diagnostic categories with multiple comparisons to identify the differences between the diagnostic categories, deeming p < 0.05 as statistically significant. Results: The mean CH in the DG group (9.69 mmHg) was significantly lower compared to controls (10.75 mmHg; mean difference 1.05, p < 0.001), FHG (10.70 mmHg; mean difference 1.00, p < 0.05), GLD (10.63 mmHg; mean difference 0.93, p < 0.05) and OHT (10.54 mmHg; mean difference 0.84, p < 0.05). No glaucoma suspects (FHG, GLD, OHT groups) presented significant differences between themselves and the control group (p = 1.00). No statistically significant differences were found in the mean CRF between DG (11.18 mmHg) and the control group (10.75 mmHg; mean difference 0.42, p = 0.40). The FHG and OHT groups showed significantly higher mean CRF values (12.32 and 12.41 mmHg, respectively) than the DG group (11.18 mmHg), with mean differences of 1.13 (p < 0.05) and 1.22 (p < 0.001), respectively. No statistically significant differences were found in CCT in the analysis between DG (562 μ) and the other groups (control = 556 μ, FHG = 576 μ, GLD = 569 μ, OHT = 570 μ). The means of IOPg and IOPcc values were higher in the DG patient and suspect groups than in the control group, with statistically significant differences in all groups (p < 0.001). Conclusion: This study presents corneal biomechanical values (CH, CRF), CCT, IOPg, and IOPcc for diagnosed glaucoma patients, three suspected glaucoma groups, and a healthy population, using the ORA. Mean CH values were markedly lower in the DG group (diagnosed with glaucoma damage) compared to the other groups. No significant difference was found in CCT between the DG and control groups. Unexpectedly, CRF showed higher values in all groups than in the control group, but the difference was only statistically significant in the suspect groups (FHG, GLD, and OHT), not in the DG group.

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Section: Chmentioning

confidence: 99%

Corneal Biomechanical Parameters and Central Corneal Thickness in Glaucoma Patients, Glaucoma Suspects, and a Healthy Population

Buey-Sayas

Lanchares

Campíns‐Falcó

et al. 2021

JCM

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“…Lanzagorta-Aresti et al, Vu et al, and Lee et al examined spectral-domain coherence tomography (SD-OCT; Heidelberg Engineering GmbH, Heidelberg, Germany) as a means of comparing CH and pressure-induced glaucomatous damage. [26][27][28] Lee et al outlined the relationship between baseline CH and lamina cribrosa curvature in 65 treatment naïve POAG patients. 28 Lamina cribrosa curvature was assessed via the lamina cribrosa index, a combination of the anterior lamina cribrosa curve depth and width of reference line.…”

Section: The Anatomical Connectionmentioning

confidence: 99%

“…[26][27][28] Lee et al outlined the relationship between baseline CH and lamina cribrosa curvature in 65 treatment naïve POAG patients. 28 Lamina cribrosa curvature was assessed via the lamina cribrosa index, a combination of the anterior lamina cribrosa curve depth and width of reference line. Lower baseline CH measurements correlated with greater posterior displacement of the lamina cribrosa (p = 0.001).…”

Section: The Anatomical Connectionmentioning

confidence: 99%

“…Lower baseline CH measurements correlated with greater posterior displacement of the lamina cribrosa (p = 0.001). 28 This suggests a potential relatedness between the connective tissue seen in the cornea and lamina cribrosa. Anterior and posterior displacement of the lamina cribrosa has been linked to changes in intraocular pressure.…”

Section: The Anatomical Connectionmentioning

confidence: 99%

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<p>Corneal Hysteresis as a Biomarker of Glaucoma: Current Insights</p>

Zimprich

Diedrich²,

Bleeker

et al. 2020

OPTH

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The diagnosis and management of glaucoma has long been dependent on making decisions based on family history, optic nerve head evaluation, intraocular pressure, visual field testing, and optical coherence testing. Other pieces to aid in understanding glaucoma have presented throughout the years, including the role of corneal thickness. The discussion and debate on the mechanism of glaucoma have been attributed to resistance at the level of the conventional outflow pathway, perfusion pressure to the optic nerve head, cerebral spinal fluid pressure, and many more. Another piece that has emerged is corneal hysteresis, an assessment of the cornea's ability to absorb and dissipate energy. There is abundant published literature supporting corneal hysteresis being associated with the presence and severity of glaucoma, the structural and functional progression of glaucoma, and the conversion to glaucoma. The supported data in these studies add another piece, corneal hysteresis, to consider in the diagnosis and management of glaucoma.

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“…In other words, corneal biomechanics, including CH, can be an alternative for the evaluation of overall ocular biomechanics. This presents as a possible indicator of glaucomatous damage [10][11][12][13][14][15][16][17][18][19][20][21]. However, in most clinics, the instrument that measures CH is not readily available and yet to be clinically used for glaucoma evaluation.…”

Section: Introductionmentioning

confidence: 99%

Rate of central corneal thickness changes in primary angle closure eyes: long-term follow-up results

et al. 2021

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Background Central corneal thickness (CCT) and its association with intraocular pressure, which is a pivotal parameter in glaucoma management, has previously been reported. In this study, we intended to investigate the long-term change of CCT in terms of rate in eyes with primary angle-closure (PAC). Additionally, we aimed to analyze events that could affect CCT. Methods In this retrospective study, 26 patients with PAC who had a follow-up period of more than 5 years were analyzed. The rate of CCT changes from baseline was evaluated from the serial CCT measurements over the average follow-up period. The pattern of CCT change rate according to modes of treatment and history of angle-closure attack was analyzed using the repeated linear mixed model analysis. Results A total of 52 eyes were enrolled. The CCT reduction rate of the entire study population was − 0.72 ± 0.22 μm/yr (P = 0.001) with statistical significance. The CCT thinning rate of the laser peripheral iridotomy (PI) group was − 0.53 ± 0.25 μm/yr (P = 0.034) and that of the surgical trabeculectomy group was − 1.32 ± 0.43 μm/yr (P = 0.002), and it was not statistically significant (P = 0.112). The rate of CCT thinning in patients with a history of acute angle-closure attack was − 0.81 ± 0.31 μm/yr (P = 0.009) and that in patients without an attack was − 0.63 ± 0.30 μm/yr (P = 0.001), and it was not statistically significant (P = 0.680). Baseline CCT appeared to be the only significant factor affecting the rate of CCT changes (P < 0.001). Conclusions We found a significant reduction in CCT over a long observation period in PAC eyes. We also found that the rates of CCT reduction were not affected by different treatment modalities or acute angle-closure attacks. The analysis of long-term CCT changes in conjunction with baseline CCT would also be helpful in the clinical evaluation of the PAC patients.

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Association of Corneal Hysteresis With Lamina Cribrosa Curvature in Primary Open Angle Glaucoma

Cited by 22 publications

References 47 publications

Corneal Biomechanical Parameters and Central Corneal Thickness in Glaucoma Patients, Glaucoma Suspects, and a Healthy Population

Corneal Biomechanical Parameters and Central Corneal Thickness in Glaucoma Patients, Glaucoma Suspects, and a Healthy Population

<p>Corneal Hysteresis as a Biomarker of Glaucoma: Current Insights</p>

Rate of central corneal thickness changes in primary angle closure eyes: long-term follow-up results

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