&lt;p&gt;Corneal Hysteresis as a Biomarker of Glaucoma: Current Insights&lt;/p&gt;

Zimprich, Larae; Diedrich, Jacob; Bleeker, Adam; Schweitzer, Justin

doi:10.2147/opth.s236114

Cited by 33 publications

(24 citation statements)

References 27 publications

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“…Congdon and colleagues 13 first showed that CCT and CH are both associated with development of POAG. This new finding was further confirmed by several follow up studies 14 – 17 . A recent study suggests that CH may predict visual field progression in suspected eyes with apparently well-controlled IOP 18 .…”

Section: Introductionsupporting

confidence: 64%

Association between visual field damage and corneal structural parameters

Lavric

Popa

Takahashi

et al. 2021

Sci Rep

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The main goal of this study is to identify the association between corneal shape, elevation, and thickness parameters and visual field damage using machine learning. A total of 676 eyes from 568 patients from the Jichi Medical University in Japan were included in this study. Corneal topography, pachymetry, and elevation images were obtained using anterior segment optical coherence tomography (OCT) and visual field tests were collected using standard automated perimetry with 24-2 Swedish Interactive Threshold Algorithm. The association between corneal structural parameters and visual field damage was investigated using machine learning and evaluated through tenfold cross-validation of the area under the receiver operating characteristic curves (AUC). The average mean deviation was − 8.0 dB and the average central corneal thickness (CCT) was 513.1 µm. Using ensemble machine learning bagged trees classifiers, we detected visual field abnormality from corneal parameters with an AUC of 0.83. Using a tree-based machine learning classifier, we detected four visual field severity levels from corneal parameters with an AUC of 0.74. Although CCT and corneal hysteresis have long been accepted as predictors of glaucoma development and future visual field loss, corneal shape and elevation parameters may also predict glaucoma-induced visual functional loss.

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Section: Introductionsupporting

confidence: 64%

Association between visual field damage and corneal structural parameters

Lavric

Popa

Takahashi

et al. 2021

Sci Rep

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“…Corneal biomechanics is a subject of tremendous clinical research interest in modern ophthalmology. Knowledge of corneal biomechanics is useful in several clinical applications, including management of glaucoma and ectasia risk profiling (Esporcatte et al, 2020;Zimprich et al, 2020). The integration of tomographic and biomechanical data has demonstrated potential to improve the accuracy of detection of ectatic disease and identify susceptibility to develop this complication after laser vision correction (Ambrósio et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics

Zhu

et al. 2021

Front. Bioeng. Biotechnol.

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Purpose: To evaluate the dependence of biomechanical metrics on intraocular pressure (IOP).Methods: 233 refractive surgery patients were included in this study—all were examined 3 times with the Corvis ST before and after dilation, and the differences (∆) in the main device parameters were assessed. The data collected included the biomechanically corrected IOP (bIOP), the central corneal thickness (CCT), and six dynamic corneal response (DCR) parameters, namely DA, DARatio2mm, IIR, SP-A1, CBI, and SSI. Participants were divided into three groups according to the changes in patients’ bIOP after mydriasis.Results: Intra-operator repeatability was generally high in most of the DCR parameters obtained before and after dilation. The mean changes in bIOP and CCT after dilation were −0.12 ± 1.36 mmHg and 1.95 ± 5.23 μm, respectively. Only ∆DARatio2mm, ∆IIR, and ∆CBI exhibited a statistically significant correlation with ∆CCT (p < 0.05). The changes in all DCR parameters, especially ∆DA and ∆SP-A1 were also correlated with ∆bIOP (p < 0.01)—a 1-mmHg change in bIOP was associated, on average, with 5.612 and −0.037 units of change in SP-A1 and DA, respectively. In contrast, the weakest correlation with ∆bIOP was exhibited by ∆SSI.Conclusion: Most corneal DCR parameters, provided by the Corvis ST, were correlated with IOP, and more weakly with CCT. Changes experienced in CCT and IOP should therefore be considered in studies on corneal biomechanics and how it is affected by disease progression and surgical or medical procedures.

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“…On the other hand, tissues with high CH can absorb energy efficiently and do not deform as much. Eyes with lower CH are more prone to glaucomatous damage of the optic nerve as the connective tissue around it deforms significantly (compared to eyes with high CH) as a result of the effect of the IOP and this can lead to damage of optic nerve fibers that run through the LC [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Antiglaucoma Procedures (Trabeculectomy vs. Ex-PRESS Glaucoma Drainage Implant) on the Corneal Biomechanical Properties

Konstantinidis

Panagiotopoulou

Panos

et al. 2021

JCM

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The aim of this study is to investigate the effect of two antiglaucoma procedures, namely trabeculectomy and Ex-PRESS mini-shunt insertion on the biomechanical properties of the cornea. This is a prospective study. Thirty patients (30 eyes) were included in the study. Nineteen eyes had an Ex-PRESS shunt inserted (Group 1) and 11 had trabeculectomy (Group 2). The examination time points for both groups were one to three weeks preoperatively and at month 1, 6, and 12 postoperatively. Corneal biomechanical properties (corneal hysteresis (CH) corneal resistance factor (CRF)) were measured with the Ocular Response Analyzer (ORA). In group 1, CH was significantly increased at 6 and 12 months compared to baseline values. Corneal hysteresis was also higher at 1 month postoperatively, but this increase did not reach statistical significance. In group 2, the CH was significantly increased at all time points compared to the preoperative values. CRF decreased at all time points postoperatively compared to the preoperative values in both groups. The difference (preoperative values to postoperative values at all time points) of the CH and CRF between the two groups was also compared and no significant differences were detected between the two surgical techniques. Trabeculectomy and the EX-PRESS mini-shunt insertion significantly alter the corneal biomechanical properties as a result of the surgical trauma and the presence of the shunt in the corneal periphery. When compared between them, they affect the corneal biomechanical properties in a similar way.

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<p>Corneal Hysteresis as a Biomarker of Glaucoma: Current Insights</p>

Cited by 33 publications

References 27 publications

Association between visual field damage and corneal structural parameters

Association between visual field damage and corneal structural parameters

Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics

The Effect of Antiglaucoma Procedures (Trabeculectomy vs. Ex-PRESS Glaucoma Drainage Implant) on the Corneal Biomechanical Properties

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